Emma Kenyon
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(Updated) Investigating the role of ethanolamine plasmalogen lipid in zebrafish brain by interdisciplinary lipidomics. Open
Neurolipidomics (Han, 2007), an evolving field at the intersection between lipid research and neuroscience, aims to offer insights into brain lipid function and thus inform the diagnosis and treatment of neurological disorders. Lipids, enc…
Investigating the role of ethanolamine plasmalogen lipid in zebrafish brain by interdisciplinary lipidomics Open
Neurolipidomics 1 , an evolving field at the intersection between lipid research and neuroscience, aims to offer insights into brain lipid function and thus inform the diagnosis and treatment of neurological disorders. Lipids, encompassing…
Editorial: Model systems in hearing research Open
EDITORIAL article Front. Cell Dev. Biol., 19 January 2024Sec. Molecular and Cellular Pathology Volume 12 - 2024 | https://doi.org/10.3389/fcell.2024.1340344
View article: Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives
Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives Open
The styryl dye FM1-43 is widely used to study endocytosis but behaves as a permeant blocker of the mechano-electrical transducer (MET) channel in sensory hair cells, loading rapidly and specifically into the cytoplasm of hair cells in a ME…
Environment predicts seagrass genotype, phenotype, and associated biodiversity in a temperate ecosystem Open
Coastal vegetative ecosystems are among the most threatened in the world, facing multiple anthropogenic stressors. A good example of this is seagrass, which supports carbon capture, coastal stabilization, and biodiversity, but is declining…
View article: Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity
Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity Open
To identify small molecules that shield mammalian sensory hair cells from the ototoxic side effects of aminoglycoside antibiotics, 10,240 compounds were initially screened in zebrafish larvae, selecting for those that protected lateral-lin…
View article: Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel
Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel Open
Aminoglycosides (AGs) are broad-spectrum antibiotics used for the treatment of serious bacterial infections but have use-limiting side effects including irreversible hearing loss. Here, we assessed the otoprotective profile of carvedilol i…
View article: Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death
Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death Open
Aminoglycoside antibiotics are used to treat life-threatening bacterial infections but can cause deafness due to hair cell death in the inner ear. Compounds have been described that protect zebrafish lateral line hair cells from aminoglyco…
d-Tubocurarine and Berbamine: Alkaloids That Are Permeant Blockers of the Hair Cell's Mechano-Electrical Transducer Channel and Protect from Aminoglycoside Toxicity Open
Aminoglycoside antibiotics are widely used for the treatment of life-threatening bacterial infections, but cause permanent hearing loss in a substantial proportion of treated patients. The sensory hair cells of the inner ear are damaged fo…
Fractal measures of spatial pattern as a heuristic for return rate in vegetative systems Open
Measurement of population persistence is a long-standing problem in ecology; in particular, whether it is possible to gain insights into persistence without long time-series. Fractal measurements of spatial patterns, such as the Korcak exp…
Additional file 2: Table S1. of Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis Open
Absolute numbers of embryos after injection with control, mismatch or flcn morpholinos. Columns show: injection group - where each group was injected on a different day, treatment group â where embryos were either uninjected, injected with…