Emma Klacking
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View article: Space-associated stem cell hallmarks of aging and resilience in astronauts
Space-associated stem cell hallmarks of aging and resilience in astronauts Open
Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere alterations after prolonged spaceflight. However, the stress of space on hematopoietic stem and progenitor cells (HSPCs) and the r…
View article: Space associated stem cell hallmarks of aging (SASHA) in astronauts
Space associated stem cell hallmarks of aging (SASHA) in astronauts Open
Previous reports revealed immune dysfunction, chromosomal abnormalities, cytokine deregulation, and telomere length dynamics following prolonged spaceflight. However, the stress of space on hematopoietic stem and progenitor cells (HSPCs) t…
View article: Defining the Roles of Base Deaminase and Splicing Deregulation in Pediatric B-Cell Acute Lymphoblastic Leukemia Stem Cell Persistence
Defining the Roles of Base Deaminase and Splicing Deregulation in Pediatric B-Cell Acute Lymphoblastic Leukemia Stem Cell Persistence Open
INTRODUCTION Leukemia stem cell (LSC) persistence contributes to relapse, which is the leading cause of death in pediatric patients with B cell acute lymphoblastic leukemia (B-ALL). As the most common childhood malignancy, identification o…
View article: Selective Reversal of ADAR1 Splicing Prevents Leukemia Stem Cell Maintenance In Vivo
Selective Reversal of ADAR1 Splicing Prevents Leukemia Stem Cell Maintenance In Vivo Open
Introduction Acute myeloid leukemia (AML) is characterized by a clonal proliferation of myeloid progenitors with a reduced capacity to differentiate into more mature cellular elements. Adenosine deaminase acting on RNA 1 (ADAR1) is an enzy…
View article: Accelerated Hematopoietic Stem Cell Aging in Space
Accelerated Hematopoietic Stem Cell Aging in Space Open
Stem cell aging is accelerated by macroenvironmental and microenvironmental stressors, including inflammation. Previously, the NASA Twins study revealed inflammatory cytokine upregulation, chromosomal alterations, and telomere changes sugg…