Emma Lång
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View article: Topological defects in polar active matter
Topological defects in polar active matter Open
Polar active matter - including animal herds, aggregates of motile cells and active colloids - often forms coordinated migration patterns, such as flocking. This orderly motion can be disrupted by full-integer topological defects represent…
View article: Topology-guided polar ordering of collective cell migration
Topology-guided polar ordering of collective cell migration Open
The ability of epithelial monolayers to self-organize into a dynamic polarized state, where cells migrate in a uniform direction, is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing l…
View article: CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival
CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival Open
Glioblastoma is the most prevalent and aggressive malignant tumor of the central nervous system. With a median overall survival of only one year, glioblastoma patients have a particularly poor prognosis, highlighting a clear need for novel…
View article: Integer topological defect annihilations drive polar ordering of epithelial monolayers
Integer topological defect annihilations drive polar ordering of epithelial monolayers Open
The ability of epithelial monolayers to self-organize into a dynamic polarized state is essential for tissue regeneration, development, and tumor progression. However, the mechanisms governing long-range polar ordering in biological tissue…
View article: P10.12.A CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival
P10.12.A CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival Open
Background Glioblastoma multiforme (GBM) is the most prevalent and aggressive malignant tumor of the central nervous system. With a median survival of only one year, GBM patients have a particularly poor prognosis, highlighting a clear nee…
View article: Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence Open
Cellular quiescence is a state of reversible cell cycle arrest that is associated with tissue dormancy. Timely regulated entry into and exit from quiescence is important for processes such as tissue homeostasis, tissue repair, stem cell ma…
View article: Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence Open
Cellular quiescence is a state of reversible cell cycle arrest that is associated with tissue dormancy. Timely regulated entry into and exit from quiescence is important for processes such as tissue homeostasis, tissue repair, stem cell ma…
View article: PML Bodies in Mitosis
PML Bodies in Mitosis Open
Promyelocytic leukemia (PML) bodies are dynamic intracellular structures that recruit and release a variety of different proteins in response to stress, virus infection, DNA damage and cell cycle progression. While PML bodies primarily are…
View article: Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding
Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding Open
View article: Influence of acute promyelocytic leukemia therapeutic drugs on nuclear pore complex density and integrity
Influence of acute promyelocytic leukemia therapeutic drugs on nuclear pore complex density and integrity Open
View article: Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites
Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites Open
Selective nuclear import in eukaryotic cells involves sequential interactions between nuclear import receptors and phenylalanine-glycine (FG)-repeat nucleoporins. Traditionally, binding of cargoes to import receptors is perceived as a nucl…
View article: Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins
Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins Open
Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of t…
View article: The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation
The Inner Membrane Protein PilG Interacts with DNA and the Secretin PilQ in Transformation Open
Expression of type IV pili (Tfp), filamentous appendages emanating from the bacterial surface, is indispensable for efficient neisserial transformation. Tfp pass through the secretin pore consisting of the membrane protein PilQ. PilG is a …