Explanipedia

Pulsation of brain tissue increases in response to caffeine: A pilot healthy volunteer study Open

Jennifer K. Nicholls, Andrea Lecchini‐Visintini, Alanoud Almudayni, Jonathan Ince, Jatinder S. Minhas , et al. · 2025

Objective Caffeine is known to induce cerebral vasoconstriction. We used this effect in a pilot ultrasound-based healthy volunteer study to investigate the directionality of response of brain tissue pulsations (BTPs) with changing middle c…

<span>ULTRA</span>‐Metrics Open

Steve Reid, Alberto Goffi, Ean Tsou, Emanuele Pivetta, Suean Pascoe , et al. · 2025

Objectives Ultrasound competency is critical in modern healthcare, yet no standardized framework currently supports ultrasound skill monitoring across diverse clinical settings and user types. Existing frameworks often lack generalizabilit…

ULTRA-metrics: Delphi-Derived Framework for Assessing Ultrasound Competency Open

Emanuele Pivetta, Mike Smith, Colin Bell, Simon Hayward, Emma M.L. Chung , et al. · 2025

The pulsing brain: state of the art and an interdisciplinary perspective Open

Andrea Lecchini‐Visintini, Jaco J.M. Zwanenburg, Qiuting Wen, Jennifer K. Nicholls, Thomas Desmidt , et al. · 2025

Understanding the pulsing dynamics of tissue and fluids in the intracranial environment is an evolving research theme aimed at gaining new insights into brain physiology and disease progression. This article provides an overview of related…

The Pulsing Brain: Part II Open

Andrea Lecchini‐Visintini, Emma M.L. Chung, Samantha Holdsworth, Jatinder S. Minhas, Stephen J. Payne · 2025

A brief history of the development of transcranial tissue Doppler ultrasound Open

Jennifer K. Nicholls, Andrea Lecchini‐Visintini, Jonathan Ince, Edward Pallett, Jatinder S. Minhas , et al. · 2024

This article documents the early development of the first transcranial Doppler (TCD)-based ultrasound system for continuous monitoring of brain tissue pulsations (BTPs). Transcranial tissue Doppler (TCTD) uses a lightweight, wearable singl…

The pulsing brain: part I Open

Andrea Lecchini‐Visintini, Emma M.L. Chung, Samantha Holdsworth, Jatinder S. Minhas, Stephen J. Payne · 2024

Effectiveness of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal: a cluster randomised trial in Pakistan Open

Joanna Maselko, Siham Sikander, Edwin L. Turner, Lisa M. Bates, Imran Ahmad , et al. · 2024

Effects of Blood Pressure on Brain Tissue Pulsation Amplitude in a Phantom Model Open

Jennifer K. Nicholls, Poppy Turner, Andrea Lecchini‐Visintini, Jonathan Ince, Georgina de Vries , et al. · 2023

Increments in BP were significantly associated with increments in bulk BTP amplitude. Further work should aim to confirm the relationship between BP and BTPs in the presence of cerebral autoregulation and explore further physiological fact…

Are portable ankle brachial pressure index measurement devices suitable for hypertension screening? Open

Justyna Janus, Jennifer K. Nicholls, Edward Pallett, Matthew J. Bown, Emma M.L. Chung · 2023

Objective In a large-scale population cardiovascular screening programme, peripheral artery disease (PAD) and hypertension would ideally be rapidly assessed using a single device. The ankle-brachial pressure index (ABPI) is calculated by c…

Three-dimensional simulations of embolic stroke and an equation for sizing emboli from imaging Open

J. P. Hague, Jonathan Keelan, Lucy Beishon, David Swienton, Thompson Robinson , et al. · 2023

Assessment of the Imaging Properties of 3D-Printable Material using Dual Energy Computed Tomography Open

Lisa M. Rowley, Elizabeth M Davies, Emma M.L. Chung · 2023

Aim: Assessment of the imaging properties of 3D-printable materials using dual energy computed tomography (DECT) to match clinical values for imaging phantoms. Methods: 3D-printed samples were imaged using DECT. Regions of interest were an…

Magnetic resonance imaging of the pulsing brain: a systematic review Open

Alanoud Almudayni, Meshal Alharbi, Alimul Chowdhury, Jonathan Ince, Fatmah Alablani , et al. · 2022

Objective To perform a systematic review of the literature exploring magnetic resonance imaging (MRI) methods for measuring natural brain tissue pulsations (BTPs) in humans. Methods A prospective systematic search of MEDLINE, SCOPUS and Op…

Development of a Flow Phantom for Transcranial Doppler Ultrasound Quality Assurance Open

Fatmah Alablani, Justyna Janus, Edward Pallett, Toni M. Mullins, Alanoud Almudayni , et al. · 2022

Anecdotal evidence was recently brought to our attention suggesting a potential difference in velocity estimates between transcranial Doppler (TCD) systems when measuring high velocities (∼200 cm/s) close to the threshold for sickle cell d…

Selecting Portable Ankle/Toe Brachial Pressure Index Systems for a Peripheral Arterial Disease Population Screening Programme: a Systematic Review, Clinical Evaluation Exercise, and Consensus Process Open

Emma Watson, Bhavisha Patel, Emmanuel Katsogridakis, Coral Pepper, Sarah Jane Messeder , et al. · 2022

The MESI system is a good candidate to consider for community PAD screening.

Improving communications in PPE: A solution for landline telephone communication. Open

Tim Coats, Edward Pallett, J. Mangat, Emma M.L. Chung · 2022

Background. Emergency care staff wearing elastomeric respiratory PPE report difficulties in communicating by telephone. We developed and tested an affordable technological solution aimed at improving telephone call intelligibility in staff…

Paediatric brain MRI findings following congenital heart surgery: a systematic review Open

Fatmah Alablani, Hoi Shan Asia Chan, Lucy Beishon, Nikil Patel, Alanoud Almudayni , et al. · 2022

Objective This systematic review aimed to establish the relative incidence of new postoperative brain MRI findings following paediatric congenital cardiac surgery. Design To distinguish perioperative changes from pre-existing MR findings, …

Ultrasound shear wave elastography imaging of common carotid arteries in patients with Spontaneous Coronary Artery Dissection (SCAD) Open

Fahad Almutairi, Abtehal Al-hussaini, Anne-Marie Marsh, Nilesh J. Samani, Gerry P McCann , et al. · 2022

Background Shear wave elastography (SWE) is emerging as a valuable clinical tool for a variety of conditions. The aim of this pilot study was to assess the potential of SWE imaging of the common carotid arteries (CCA) in patients with spon…

Emerging Detection Techniques for Large Vessel Occlusion Stroke: A Scoping Review Open

Jennifer K. Nicholls, Jonathan Ince, Jatinder S. Minhas, Emma M.L. Chung · 2022

Background: Large vessel occlusion (LVO) is the obstruction of large, proximal cerebral arteries and can account for up to 46% of acute ischaemic stroke (AIS) when both the A2 and P2 segments are included (from the anterior and posterior c…

Three dimensional simulations of embolic stroke: clinical comparisons and an equation for sizing emboli from imaging Open

J. P. Hague, Jonathan Keelan, Lucy Beishon, David Swienton, Thompson Robinson , et al. · 2021

There is a need to develop Monte Carlo simulations of stroke to run in-silico trials to replace animal models, explore clinical scenarios to develop hypotheses for clinical studies and for interpreting clinical monitoring. We perform three…

Three dimensional simulations of embolic stroke: clinical comparisons\n and an equation for sizing emboli from imaging Open

J. P. Hague, Jonathan Keelan, Lucy Beishon, David Swienton, Thompson Robinson , et al. · 2021

There is a need to develop Monte Carlo simulations of stroke to run in-silico\ntrials to replace animal models, explore clinical scenarios to develop\nhypotheses for clinical studies and for interpreting clinical monitoring. We\nperform th…

131 Erector spinae block for perioperative pain management in children undergoing thoracotomy Open

Emad B. Mossad, Emma M.L. Chung · 2021

Background and Aims Thoracotomy for pediatric cardiac surgery can be associated with significant pain. Regional anesthesia techniques such as epidurals and paravertebral blocks can reduce the pain of thoracotomy but can also be associated …

Does radiology require informed consent for radiation risk? Open

Elizabeth M Davies, Andrew J Bridges, Emma M.L. Chung · 2021

Recent trends in medical decision-making have moved from paternalistic doctor-patient relations to shared decision-making. Informed consent is fundamental to this process and to ensuring patients’ ongoing trust in the health-care professio…

A Novel Elastography Phantom Prototype for Assessment of Ultrasound Elastography Imaging Performance Open

Fahad Almutairi, Emma M.L. Chung, Carmel M. Moran, Kumar V. Ramnarine · 2021

The Effects of Hypocapnia on Brain Tissue Pulsations Open

Meshal Alharbi, Poppy Turner, Jonathan Ince, Mitsuhiro Oura, Kelechi U. Ebirim , et al. · 2020

Hypocapnia is known to affect patients with acute stroke and plays a key role in governing cerebral autoregulation. However, the impact of hypocapnia on brain tissue pulsations (BTPs) is relatively unexplored. As BTPs are hypothesised to r…

Neurological impact of emboli during adult cardiac surgery Open

Nikil Patel, Caroline Banahan, Justyna Janus, Mark A. Horsfield, A. D. Cox , et al. · 2020

Common carotid artery stiffness in patients with Spontaneous Coronary Artery Dissection (SCAD) is comparable to non-dissection controls Open

Fahad F Almutairi, Abtehal Al-hussaini, Anne-Marie Marsh, Nilesh J. Samani, Gerry P McCann , et al. · 2020

Background: Arterial dissection is a rare but potentially life-threatening condition, hypothesized to be linked to changes in vessel wall elasticity. This study aimed to provide an insight into the pathophysiology of arterial dissection by…

Ultrasound measurement of brain tissue movement in humans: A systematic review Open

Jonathan Ince, Meshal Alharbi, Jatinder S. Minhas, Emma M.L. Chung · 2019

Introduction It has long been suggested that ultrasound could be used to measure brain tissue pulsations in humans, but potential clinical applications are relatively unexplored. The aim of this systematic review was to explore and synthes…

Part II. Comparison of Neurodevelopmental Outcomes Between Normothermic and Hypothermic Pediatric Cardiopulmonary Bypass Open

Claire Hannon, Zachary Osman, Cathy Grant, Emma M.L. Chung, Antonio F. Corno · 2019

Objectives: In the previous study we demonstrated that normothermic cardiopulmonary bypass (N-CPB, ≥35°C) provided better early clinical outcomes compared to mild/moderate hypothermic cardiopulmonary bypass (H-CPB, 28-34°C) for cong…

Response by Patel et al to Letter Regarding Article, “Perioperative Cerebral Microbleeds After Adult Cardiac Surgery” Open

Nikil Patel, Claire Hannon, Emma M.L. Chung · 2019

Emma M.L. Chung YOU? Author Swipe