Emma McCullagh
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View article: Ybiv from Escherichia coli K12 is a HAD phosphatase
Ybiv from Escherichia coli K12 is a HAD phosphatase Open
The protein YbiV from Escherichia coli K12 MG1655 is a hypothetical protein with sequence homology to the haloacid dehalogenase (HAD) superfamily of proteins. Although numerous members of this family have been identified, the functions of …
View article: Natural history study of glycan accumulation in large animal models of GM2 gangliosidoses
Natural history study of glycan accumulation in large animal models of GM2 gangliosidoses Open
β-hexosaminidase is an enzyme responsible for the degradation of gangliosides, glycans, and other glycoconjugates containing β-linked hexosamines that enter the lysosome. GM2 gangliosidoses, such as Tay-Sachs and Sandhoff, are lysosomal st…
View article: Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions
Central nervous system pathology in preclinical MPS IIIB dogs reveals progressive changes in clinically relevant brain regions Open
Mucopolysaccharidosis type IIIB (MPS IIIB; Sanfilippo syndrome B) is an autosomal recessive lysosomal storage disorder caused by the deficiency of alpha- N -acetylglucosaminidase activity, leading to increased levels of nondegraded heparan…
View article: Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ
Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ Open
The aberrant activation of B-cells has been implicated in several types of cancers and hematological disorders. BTK and PI3Kδ are kinases responsible for B-cell signal transduction, and inhibitors of these enzymes have demonstrated clinica…
View article: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Open
Two ER membrane-resident transmembrane kinases, IRE1 and PERK, function as stress sensors in the unfolded protein response. IRE1 also has an endoribonuclease activity, which initiates a non-conventional mRNA splicing reaction, while PERK p…
View article: Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic
Author response: Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Two ER membrane-resident transmembrane kinases,…