Emma A. Morrison
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View article: Histone H3 tail charge patterns govern nucleosome condensate formation and dynamics
Histone H3 tail charge patterns govern nucleosome condensate formation and dynamics Open
Emerging models of nuclear organization suggest that chromatin forms functionally distinct microenvironments through phase separation. As chromatin architecture is organized at the level of the nucleosome and regulated by histone post-tran…
View article: Arginine anchor points govern H3 tail dynamics
Arginine anchor points govern H3 tail dynamics Open
Chromatin is dynamically reorganized spatially and temporally, and the post-translational modification of histones is a key component of this regulation. The basic subunit of chromatin is the nucleosome core particle, consisting of two cop…
View article: Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility
Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility Open
Hexasomes and tetrasomes are intermediates in nucleosome assembly and disassembly. Their formation is promoted by histone chaperones, ATP-dependent remodelers, and RNA polymerase II. In addition, hexasomes are maintained in transcribed gen…
View article: Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain
Evolutionary Conservation of Structural and Functional Coupling between the BRM AT-Hook and Bromodomain Open
The BAF chromatin remodeling complex is critical for genome regulation. The central ATPase of BAF is either BRM or BRG1, both of which contain a C-terminal bromodomain, known to associate with acetylated lysines. We have recently demonstra…
View article: Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility
Nucleosome composition regulates the histone H3 tail conformational ensemble and accessibility Open
Sub-nucleosomal complexes including hexasomes and tetrasomes have been identified as intermediates in nucleosome assembly and disassembly. Their formation is promoted by certain histone chaperones and ATP-dependent remodelers, as well as t…
View article: RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression
RNA Splicing of the BHC80 Gene Contributes to Neuroendocrine Prostate Cancer Progression Open
The main obstacle to develop effective therapies for patients with t-NEPC is the lack of understanding on how t-NEPC is developed. Our study not only identifies a previously unknown BHC80-2-MyD88 signaling pathway that plays an important r…
View article: Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains
Reading More than Histones: The Prevalence of Nucleic Acid Binding among Reader Domains Open
The eukaryotic genome is packaged into the cell nucleus in the form of chromatin, a complex of genomic DNA and histone proteins. Chromatin structure regulation is critical for all DNA templated processes and involves, among many things, ex…
View article: The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome
The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome Open
Histone tails harbor a plethora of post-translational modifications that direct the function of chromatin regulators, which recognize them through effector domains. Effector domain/histone interactions have been broadly studied, but largel…
View article: New free-exchange model of EmrE transport
New free-exchange model of EmrE transport Open
Significance EmrE facilitates Escherichia coli multidrug resistance by coupling drug efflux to proton import. This antiport mechanism has been thought to occur via a pure-exchange model, which achieves coupled antiport by restricting when …
View article: Author response: The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome
Author response: The conformation of the histone H3 tail inhibits association of the BPTF PHD finger with the nucleosome Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Histone tails harbor a plethora of post-transla…
View article: A kinetically-driven free exchange mechanism of EmrE antiport sacrifices coupling efficiency in favor of promiscuity
A kinetically-driven free exchange mechanism of EmrE antiport sacrifices coupling efficiency in favor of promiscuity Open
EmrE is a small multidrug resistance transporter found in E. coli that confers resistance to toxic polyaromatic cations due to its proton-coupled antiport of these substrates. Here we show that EmrE breaks the rules generally deemed essent…