Emma Ndagire
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View article: Circulating prothymosin alpha and immunoglobulin G3 in acute rheumatic fever and rheumatic heart disease: A case-control study
Circulating prothymosin alpha and immunoglobulin G3 in acute rheumatic fever and rheumatic heart disease: A case-control study Open
Our findings conflict with a previous report that found PTA was elevated in RHD compared to healthy controls. In contrast, while less marked than before, we found IgG3 was elevated in ARF, extending this observation to settings where the i…
View article: Circulating prothymosin alpha and immunoglobulin G3 in acute rheumatic fever and rheumatic heart disease: A case-control study
Circulating prothymosin alpha and immunoglobulin G3 in acute rheumatic fever and rheumatic heart disease: A case-control study Open
The lack of specific diagnostic tests for acute rheumatic fever (ARF) and its consequence rheumatic heart disease (RHD) is a key barrier to effective control of these diseases in low resource settings. Prothymosin alpha (PTA) and immunoglo…
View article: A plasma protein biomarker signature that differentiates acute rheumatic fever from related clinical presentations
A plasma protein biomarker signature that differentiates acute rheumatic fever from related clinical presentations Open
Acute Rheumatic Fever (ARF) is a systemic inflammatory condition triggered by Group A Streptococcus infection, with timely diagnosis critical to prevent Rheumatic Heart Disease. ARF pathogenesis is poorly understood and diagnosis is based …
View article: Enhanced support for adherence to rheumatic heart disease prophylaxis for children in the public health system in Uganda (CAMPS): a pragmatic randomised trial
Enhanced support for adherence to rheumatic heart disease prophylaxis for children in the public health system in Uganda (CAMPS): a pragmatic randomised trial Open
Thrasher Research Fund Early Career Award and Edwards LifeSciences Foundation.
View article: The impact of the COVID-19 pandemic on secondary prevention of Rheumatic Heart Disease in Western Uganda
The impact of the COVID-19 pandemic on secondary prevention of Rheumatic Heart Disease in Western Uganda Open
Background Regular outpatient visits to healthcare facilities for benzathine penicillin injections are the primary means of secondary prevention for patients with Rheumatic Heart Disease (RHD). It has been widely demonstrated that individu…
View article: Congenital heart disease cardiac catheterization at Uganda Heart Institute, a 12-year retrospective study of immediate outcomes
Congenital heart disease cardiac catheterization at Uganda Heart Institute, a 12-year retrospective study of immediate outcomes Open
Many patients with CHD have benefited from the cardiac catheterization program at UHI with high optimal procedure outcome results. Patients with advanced heart failure at the time of cardiac catheterization have less favorable outcomes emp…
View article: Primary surgical repair of tetralogy of fallot at the Uganda Heart Institute: a ten-year review of 30day mortality and morbidity
Primary surgical repair of tetralogy of fallot at the Uganda Heart Institute: a ten-year review of 30day mortality and morbidity Open
Background Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease (CHD) worldwide. It accounts for 7% of CHD cases in Uganda and leads to fatal outcomes in the long term without surgery. Surgery is often del…
View article: Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial)
Intramuscular versus enteral penicillin prophylaxis to prevent progression of rheumatic heart disease: Study protocol for a noninferiority randomized trial (the GOALIE trial) Open
ClinicalTrials.gov: NCT05693545.
View article: Disparity of secondary prevention among patients with rheumatic heart disease: A longitudinal study in Uganda
Disparity of secondary prevention among patients with rheumatic heart disease: A longitudinal study in Uganda Open
Background Rheumatic heart disease (RHD) is most prevalent in socially disadvantaged settings, placing a severe burden on patients and their households. The study aims to investigate the disparity of healthcare costs, including financial a…
View article: Early Surgical Outcomes of Tetralogy of Fallot Patients Following Primary Intracardiac Repair at Uganda Heart Institute
Early Surgical Outcomes of Tetralogy of Fallot Patients Following Primary Intracardiac Repair at Uganda Heart Institute Open
Background Tetralogy of Fallot (TOF) is the commonest form of cyanotic congenital heart disease (CHD) worldwide and accounts for 7% of CHD in Uganda. Without surgery, the natural history is nearly always fatal in the long term. Surgery is …
View article: Positive impact of training rural health workers in identification and prevention of acute rheumatic fever in eastern Uganda
Positive impact of training rural health workers in identification and prevention of acute rheumatic fever in eastern Uganda Open
A critical knowledge gap is evident among health workers, both in awareness and treatment of ARF, and calls for repetitive training as a priority strategy in prevention.
View article: A Qualitative Study of Patients’ Experiences, Enablers and Barriers of Rheumatic Heart Disease Care in Uganda
A Qualitative Study of Patients’ Experiences, Enablers and Barriers of Rheumatic Heart Disease Care in Uganda Open
Despite several personal and community factors that support resilience, PLWRHD in Uganda experience a range of negative physical, emotional, and social consequences from their condition. Greater investment is needed in primary healthcare s…
View article: Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward
Cardiovascular diseases in Africa in the twenty-first century: Gaps and priorities going forward Open
In 2015, the United Nations set important targets to reduce premature cardiovascular disease (CVD) deaths by 33% by 2030. Africa disproportionately bears the brunt of CVD burden and has one of the highest risks of dying from non-communicab…
View article: Modelling study of the ability to diagnose acute rheumatic fever at different levels of the Ugandan healthcare system
Modelling study of the ability to diagnose acute rheumatic fever at different levels of the Ugandan healthcare system Open
Objective To determine the ability to accurately diagnose acute rheumatic fever (ARF) given the resources available at three levels of the Ugandan healthcare system. Methods Using data obtained from a large epidemiological database on ARF …
View article: Community Perspectives on Primary Prevention of Rheumatic Heart Disease in Uganda
Community Perspectives on Primary Prevention of Rheumatic Heart Disease in Uganda Open
The FGDs identified several approaches to shape community perceptions of pharyngitis and improve utilization of interventions to prevent RHD. In Uganda, information-education-communication interventions probably need to be combined with st…
View article: Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study
Incidence of acute rheumatic fever in northern and western Uganda: a prospective, population-based study Open
American Heart Association Children's Strategically Focused Research Network Grant, THRiVE-2, General Electric, and Cincinnati Children's Heart Institute Research Core.
View article: Establishment of a cardiac telehealth program to support cardiovascular diagnosis and care in a remote, resource-poor setting in Uganda
Establishment of a cardiac telehealth program to support cardiovascular diagnosis and care in a remote, resource-poor setting in Uganda Open
Introduction To address workforce shortages and expand access to care, we developed a telemedicine program incorporating existing infrastructure for delivery of cardiovascular care in Gulu, Northern Uganda. Our study had three objectives: …
View article: Household Economic Consequences of Rheumatic Heart Disease in Uganda
Household Economic Consequences of Rheumatic Heart Disease in Uganda Open
Background: Rheumatic heart disease (RHD) has declined dramatically in wealthier countries in the past three decades, but it remains endemic in many lower-resourced regions and can have significant costs to households. The objective of thi…
View article: Examining the Ugandan health system’s readiness to deliver rheumatic heart disease-related services
Examining the Ugandan health system’s readiness to deliver rheumatic heart disease-related services Open
Background In 2018, the World Health Assembly mandated Member States to take action on rheumatic heart disease (RHD), which persists in countries with weak health systems. We conducted an assessment of the current state of RHD-related heal…
View article: Active Case Finding for Rheumatic Fever in an Endemic Country
Active Case Finding for Rheumatic Fever in an Endemic Country Open
Background Despite the high burden of rheumatic heart disease in sub‐Saharan Africa, diagnosis with acute rheumatic fever (ARF) is exceedingly rare. Here, we report the results of the first prospective epidemiologic survey to diagnose and …
View article: Cross-sectional study of population-specific streptococcal antibody titres in Uganda
Cross-sectional study of population-specific streptococcal antibody titres in Uganda Open
Objective Despite substantial variation of streptococcal antibody titres among global populations, there is no data on normal values in sub-Saharan Africa. The objective of this study was to establish normal values for antistreptolysin O (…
View article: Establishing Cutoffs for Streptococcal Antibody Titers in Uganda: Implications for Rheumatic Fever Diagnosis
Establishing Cutoffs for Streptococcal Antibody Titers in Uganda: Implications for Rheumatic Fever Diagnosis Open
Background Central to rheumatic fever (RF) diagnosis is evidence of streptococcal exposure, specifically antistreptolysin O (ASO) and antideoxyribonuclease B (ADB) antibodies. It is unknown if these antibody titers should be adjusted to th…