Emma Seaford
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View article: A Novel Clinical Trial in Rare Paediatric B-Cell Non-Hodgkin Lymphoma: Evaluating the Glo-Bnhl Adaptive Bayesian Design Using Data from the Sparkle Trial
A Novel Clinical Trial in Rare Paediatric B-Cell Non-Hodgkin Lymphoma: Evaluating the Glo-Bnhl Adaptive Bayesian Design Using Data from the Sparkle Trial Open
Background Outcomes for relapsed or refractory (r/r) paediatric B-cell non-Hodgkin Lymphoma (B-NHL) are extremely poor with long term cure rates below 30%. A collaborative pragmatic innovative approach to trial design was required for a ne…
View article: Young paediatric oncologists and haematologists in Europe – Emerging needs and future perspectives
Young paediatric oncologists and haematologists in Europe – Emerging needs and future perspectives Open
Background: The “Young NaPHOS” project was launched in 2021, by Young SIOPE, the group for junior members of the European Society for Paediatric Oncology (SIOPE). The Young NaPHOS project aims to build a network of national representatives…
View article: A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL)
A Potential Paradigm for the Robust and Systematic Prioritisation of Assets in Academic-Led, Multi-Industry Collaborative Trials in Rare Populations (Glo-BNHL) Open
Overview Given the rarity of children and adolescents with relapsed and refractory (r/r) B-cell Non-Hodgkin Lymphoma (B-NHL) and the large number of potential agents in development for adult mature B-cell malignancies, there is urgent need…
View article: Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement
Molecular characterization and clinical outcome of B-cell precursor acute lymphoblastic leukemia with IG-MYC rearrangement Open
Rarely, immunophenotypically immature B-cell precursor acute lymphoblastic leukemia (BCP-ALL) carries an immunoglobulin- MYC rearrangement (IG-MYC-r). This can result in diagnostic confusion with Burkitt lymphoma/leukemia and use of indivi…