Emma T. Watson
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View article: Optimizing multifunctional fluorescent ligands for intracellular labeling
Optimizing multifunctional fluorescent ligands for intracellular labeling Open
Enzyme-based self-labeling tags enable the covalent attachment of synthetic molecules to proteins inside living cells. A frontier of this field is designing cell-permeable multifunctional ligands that contain fluorophores in combination wi…
View article: Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling
Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling Open
Enzyme-based self-labeling tags enable covalent attachment of synthetic molecules to proteins inside living cells. A frontier of this field is designing multifunctional ligands that contain both fluorophores and affinity tags or pharmacolo…
View article: The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation
The juxtamembrane linker of synaptotagmin 1 regulates Ca2+ binding via liquid-liquid phase separation Open
View article: The juxtamembrane linker of synaptotagmin 1 regulates Ca<sup>2+</sup>binding via liquid-liquid phase separation
The juxtamembrane linker of synaptotagmin 1 regulates Ca<sup>2+</sup>binding via liquid-liquid phase separation Open
Synaptotagmin (syt) 1, a Ca 2+ sensor for synaptic vesicle exocytosis, functions in vivo as a multimer. Syt1 senses Ca 2+ via tandem C2-domains that are connected to a single transmembrane domain via a juxtamembrane linker. Here, we show t…
View article: Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons Open
Neurotransmitter-filled synaptic vesicles (SVs) mediate synaptic transmission and are a hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic nerve terminals remains the subject of debate. The leading mo…
View article: Author response: Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
Author response: Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neurotransmitter-filled synaptic ves…
View article: Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons Open
Neurotransmitter-filled synaptic vesicles (SV) mediate synaptic transmission and are a hallmark specialization in neuronal axons. Yet, how SV proteins are sorted to presynaptic nerve terminals remains the subject of debate. The leading mod…
View article: Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways
Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways Open