Emma V. Rusilowicz-Jones
YOU?
Author Swipe
View article: A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity
A long-lived pool of PINK1 imparts a molecular memory of depolarization-induced activity Open
The Parkinson’s disease–linked kinase, PINK1, is a short-lived protein that undergoes cleavage upon mitochondrial import leading to its proteasomal degradation. Under depolarizing conditions, it accumulates on mitochondria where it becomes…
View article: A trafficking regulatory subnetwork governs α <sub>V</sub> β <sub>6</sub> integrin-HER2 cross-talk to control breast cancer invasion and drug resistance
A trafficking regulatory subnetwork governs α <sub>V</sub> β <sub>6</sub> integrin-HER2 cross-talk to control breast cancer invasion and drug resistance Open
HER2 and α V β 6 integrin are independent predictors of breast cancer survival and metastasis. We identify an α V β 6 /HER2 cross-talk mechanism driving invasion, which is dysregulated in drug-resistant HER2+ breast cancer cells. Proteomic…
View article: Microtubule association of TRIM3 revealed by differential extraction proteomics
Microtubule association of TRIM3 revealed by differential extraction proteomics Open
The microtubule network is formed from polymerised tubulin subunits and associating proteins, which govern microtubule dynamics and a diverse array of functions. To identify novel microtubule-binding proteins, we have developed an unbiased…
View article: A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance Open
HER2 and αVβ6 integrin are independent predictors of breast cancer survival and metastasis. We investigated αVβ6 signalling and identified an αVβ6/HER2 crosstalk mechanism, which drives invasion and is dysregulated in drug resistant HER2+ …
View article: ISGylation-independent protection of cell growth by USP18 following interferon stimulation
ISGylation-independent protection of cell growth by USP18 following interferon stimulation Open
Type 1 interferon stimulation highly up-regulates all elements of a ubiquitin-like conjugation system that leads to ISGylation of target proteins. An ISG15-specific member of the deubiquitylase family, USP18, is up-regulated in a co-ordina…
View article: A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance Open
HER2 and α V β 6 integrin are independent predictors of breast cancer survival and metastasis. We investigated α V β 6 signalling and identified an α V β 6 /HER2 crosstalk m…
View article: Microtubule association of TRIM3 revealed by differential extraction proteomics
Microtubule association of TRIM3 revealed by differential extraction proteomics Open
The microtubule network is formed from polymerised Tubulin subunits and associating proteins, which govern microtubule dynamics and a diverse array of functions. To identify novel microtubule binding proteins, we have developed an unbiased…
View article: ISGylation-independent protection of cell growth by USP18 following interferon stimulation
ISGylation-independent protection of cell growth by USP18 following interferon stimulation Open
Type 1 interferon stimulation highly up-regulates all elements of a ubiquitin-like conjugation system that leads to ISGylation of target proteins. An ISG15-specific member of the deubiquitylase family, USP18, is up-regulated in a co-ordina…
View article: Membrane compartmentalisation of the ubiquitin system
Membrane compartmentalisation of the ubiquitin system Open
View article: Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy Open
The deubiquitylase USP30 is an actionable target considered for treatment of conditions associated with defects in the PINK1-PRKN pathway leading to mitophagy. We provide a detailed cell biological characterization of a benzosulphonamide m…
View article: Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy
Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy Open
The deubiquitylase USP30 is an actionable target considered for treatment of conditions associated with defects in the PINK1/Parkin pathway leading to mitophagy. These include Parkinson’s disease and pulmonary fibrosis. We provide a detail…
View article: USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation
USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation Open
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. We present the characterisation of an N-cyano pyrrolidine compound, FT3967385, with high selectivity for USP30. We demonstrate tha…
View article: A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation
A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation Open
The mitochondrial deubiquitylase USP30 negatively regulates the selective autophagy of damaged mitochondria. It has been proposed as an actionable target to alleviate the loss of function of the mitophagy pathway governed by the Parkinson’…
View article: New aspects of USP30 biology in the regulation of pexophagy
New aspects of USP30 biology in the regulation of pexophagy Open
Mitochondria and peroxisomes have a number of features in common: they each play interconnected roles in fatty acid and reactive oxygen species (ROS) metabolism and, once damaged, need to be removed by specialized autophagic mechanisms, te…
View article: Dual role of <scp>USP</scp> 30 in controlling basal pexophagy and mitophagy
Dual role of <span>USP</span> 30 in controlling basal pexophagy and mitophagy Open
View article: The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity
The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity Open