Emmanuel Arinaitwe
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View article: CXCR6⁺ CD127⁻ Tr1 Cells Balance Immunity and Persistence in Plasmodium falciparum Infection
CXCR6⁺ CD127⁻ Tr1 Cells Balance Immunity and Persistence in Plasmodium falciparum Infection Open
Plasmodium falciparum ( Pf ) induces the clonal expansion of antigen-specific type 1 regulatory T (Tr1) cells with a capacity for long-term memory. Tr1 cells comprise nearly 90% of the Pf blood stage antigen-specific CD4+ T cell pool in ch…
View article: Inhibitory NK receptors regulate the γδ T cell response to malaria
Inhibitory NK receptors regulate the γδ T cell response to malaria Open
Gamma delta (γδ) T cells are important mediators of the immune response to childhood malaria infection. Human Vγ9 + Vδ2 + T cells possess intrinsic, HLA-independent responsiveness to Plasmodium falciparum phosphoantigens produced in the bl…
View article: Concordance of data on key malaria indicators between DHIS2 and source documents, and influencing factors at public primary health facilities in eastern Uganda: a mixed methods study
Concordance of data on key malaria indicators between DHIS2 and source documents, and influencing factors at public primary health facilities in eastern Uganda: a mixed methods study Open
View article: Relating household entomological measures to individual malaria risk
Relating household entomological measures to individual malaria risk Open
Background The gold standard measure of malaria exposure is the entomological inoculation rate (EIR), or the number of infectious bites an individual receives over a given period. Nevertheless, it is unclear whether EIR measured in the hou…
View article: Adjusting vector surveillance for human behaviors reveals Anopheles funestus drove a resurgence in malaria despite IRS with clothianidin in Uganda
Adjusting vector surveillance for human behaviors reveals Anopheles funestus drove a resurgence in malaria despite IRS with clothianidin in Uganda Open
After remarkable success following the implementation of indoor residual spraying (IRS) and repeated rounds of universal distribution of insecticidal treated nets in Tororo District, eastern Uganda, a switch to clothianidin-based IRS in Ma…
View article: Anopheles mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity
Anopheles mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity Open
Adults and school-age children are at higher risk of receiving mosquito bites, and this has implications for the relative importance of demographic populations to onward malaria transmission to mosquitoes.
View article: Quantifying the role of importation on sustained malaria transmission in a low-to-moderate burden region of Southwest Uganda
Quantifying the role of importation on sustained malaria transmission in a low-to-moderate burden region of Southwest Uganda Open
Background Parasite importation remains a critical challenge to malaria elimination efforts. The extent to which human travel contributes to sustained transmission in low-to-moderate burden areas of highly endemic African countries is poor…
View article: “After a long day of play, I get tired and forget to unfurl my bednet”: a qualitative study exploring factors affecting insecticide-treated bednet use among school-aged children in eastern
“After a long day of play, I get tired and forget to unfurl my bednet”: a qualitative study exploring factors affecting insecticide-treated bednet use among school-aged children in eastern Open
BACKGROUND Despite widespread access to long-lasting insecticidal nets, infection with malaria parasites remains prevalent among African school-aged children. Though this group contributes significantly to malaria transmission, few studies…
View article: Disentangling the roles of different vector species during a malaria resurgence in Eastern Uganda
Disentangling the roles of different vector species during a malaria resurgence in Eastern Uganda Open
In 2021-23, a resurgence of malaria occurred in the Tororo District of Uganda following a change in formulations used for indoor residual spraying of insecticide (IRS). Prior analyses showed that this increase was temporally associated wit…
View article: Relating household entomological measures to individual malaria risk
Relating household entomological measures to individual malaria risk Open
View article: Prevalence and factors associated with teenage pregnancy among pregnant mothers attending Rakai general hospital, Uganda: A cross-sectional study.
Prevalence and factors associated with teenage pregnancy among pregnant mothers attending Rakai general hospital, Uganda: A cross-sectional study. Open
View article: Contraceptive use and associated factors among female adolescents living in Katwe – Butego Division, Masaka District, Uganda: A cross-sectional study.
Contraceptive use and associated factors among female adolescents living in Katwe – Butego Division, Masaka District, Uganda: A cross-sectional study. Open
View article: Pfs230 Domain 12 is a potent malaria transmission-blocking vaccine candidate
Pfs230 Domain 12 is a potent malaria transmission-blocking vaccine candidate Open
Malaria transmission-blocking vaccines (TBV) target sexual stage parasites that are transmitted to mosquitoes and critical for spread of the pathogen. The clinically most advanced TBV candidate contains part of the Pro-domain (Pro) and Dom…
View article: “I desire to have an HIV-free baby”: pregnant and breastfeeding mothers’ perceptions of Viral load testing and suppression in HIV care in southwestern Uganda
“I desire to have an HIV-free baby”: pregnant and breastfeeding mothers’ perceptions of Viral load testing and suppression in HIV care in southwestern Uganda Open
The understanding and interpretation of viral suppression among pregnant and breastfeeding mothers living with HIV provides a basis for adopting behaviors leading to prevention of vertical transmission of HIV. Health care workers can suppo…
View article: Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda Open
Tororo District, Uganda experienced a dramatic decrease in malaria burden from 2015–19 during 5 years of indoor residual spraying (IRS) with carbamate (Bendiocarb) and then organophosphate (Actellic) insecticides. However, a marked resurge…
View article: Real-World Effectiveness of Deltamethrin-Clothianidin (FLUDORA FUSION) in Indoor Residual Spraying in Sub-Saharan Africa: A Systematic Review Protocol
Real-World Effectiveness of Deltamethrin-Clothianidin (FLUDORA FUSION) in Indoor Residual Spraying in Sub-Saharan Africa: A Systematic Review Protocol Open
Background Indoor residual spraying (IRS) is a core insecticide-based vector control tool employed in most malaria-affected settings globally. However, mosquito vectors have developed resistance to nearly all the insecticides currently use…
View article: Correction: Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017–2019: Implications for selection and use of HRP2 RDTs
Correction: Limitations of rapid diagnostic tests in malaria surveys in areas with varied transmission intensity in Uganda 2017–2019: Implications for selection and use of HRP2 RDTs Open
[This corrects the article DOI: 10.1371/journal.pone.0244457.].
View article: Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda Open
Background Tororo District, Uganda experienced a dramatic decrease in malaria burden from 2015-19 following 5 years of indoor residual spraying (IRS) with carbamate (Bendiocarb) and then organophosphate (Actellic) insecticides. However, a …
View article: <i>Plasmodium malariae</i> and <i>Plasmodium ovale</i>—Prevalent and Relevant
<i>Plasmodium malariae</i> and <i>Plasmodium ovale</i>—Prevalent and Relevant Open
Contains fulltext : 307856.pdf (Publisher’s version ) (Open Access)
View article: Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility of HRP2-based malaria RDTs in Northern Uganda Open
View article: A Multi-Component Integrated HIV and Hypertension Care Model Improves Hypertension Screening and Control in Rural Uganda: A Cluster Randomized Trial
A Multi-Component Integrated HIV and Hypertension Care Model Improves Hypertension Screening and Control in Rural Uganda: A Cluster Randomized Trial Open
View article: Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line
Susceptibility of Anopheles gambiae to Natural Plasmodium falciparum Infection: A Comparison between the Well-Established Anopheles gambiae s.s Line and a Newly Established Ugandan Anopheles gambiae s.s. Line Open
Much of our understanding of malaria transmission comes from mosquito feeding assays using Anopheles mosquitoes from colonies that are well adapted to membrane feeding. This raises the question whether results from colony mosquitoes lead t…
View article: Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility 1 of HRP2-based malaria RDTs in Northern Uganda
Limited threat of Plasmodium falciparum pfhrp2 and pfhrp3 gene deletion to the utility 1 of HRP2-based malaria RDTs in Northern Uganda Open
Background: Rapid diagnostic tests (RDTs) that detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2) are exclusively deployed in Uganda however deletion of the pfhrp2/3 target gene threatens their usefulness as malaria diagnosis a…
View article: Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors
Plasmodium falciparum gametocyte carriage in longitudinally monitored incident infections is associated with duration of infection and human host factors Open
Malaria transmission depends on the presence of Plasmodium gametocytes that are the only parasite life stage that can infect mosquitoes. Gametocyte production varies between infections and over the course of infections. Infection duration …
View article: Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine
Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine Open
View article: Effects of anti-malarial prophylaxes on maternal transfer of Immunoglobulin-G (IgG) and association to immunity against Plasmodium falciparum infections among children in a Ugandan birth cohort
Effects of anti-malarial prophylaxes on maternal transfer of Immunoglobulin-G (IgG) and association to immunity against Plasmodium falciparum infections among children in a Ugandan birth cohort Open
Background The in-utero transfer of malaria specific IgG to the fetus in Plasmodium falciparum infected pregnant women potentially plays a role in provision of immune protection against malaria in the first birth year. However, the effect …
View article: Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022
Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022 Open
Importance Estimating the true burden of SARS-CoV-2 infection has been difficult in sub-Saharan Africa owing to asymptomatic infections and inadequate testing capacity. Antibody responses from serologic surveys can provide an estimate of S…
View article: Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria Open
Natural killer (NK) cells likely play an important role in immunity to malaria, but the effect of repeated malaria on NK cell responses remains unclear. Here, we comprehensively profiled the NK cell response in a cohort of 264 Ugandan chil…
View article: Estimating the malaria attributable fraction of fever in cohort studies through a before and after comparison of impact: Nagongera, Tororo, Uganda, 2011-2019
Estimating the malaria attributable fraction of fever in cohort studies through a before and after comparison of impact: Nagongera, Tororo, Uganda, 2011-2019 Open
A bstract Background Malaria is an important cause of fever across much of sub-Saharan Africa and other places where Plasmodium falciparum infection is highly prevalent. Here, we estimate the fraction of fever that is attributable to malar…
View article: Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda
Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda Open
Tororo District, in Eastern Uganda, experienced a dramatic decline in malaria burden starting in 2014 following the implementation of indoor residual spraying of insecticide (IRS) in the setting of repeated long-lasting insecticide treated…