Emmanuel Bourinet
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View article: Short RFamide and CFamide peptides as novel positive modulators of Acid-Sensing Ion Channel 3 with similar potentiating effects but different reversibility
Short RFamide and CFamide peptides as novel positive modulators of Acid-Sensing Ion Channel 3 with similar potentiating effects but different reversibility Open
Acid-sensing ion channels (ASICs) are members of the DEG/ENaC family that includes the only known peptide-gated ion channels. While ASICs are gated by protons, they have kept sensitivity to peptides and are notably modulated by the mollusc…
View article: Optimized workflow for behavior-coupled fiber photometry experiment: improved data navigation and accessibility
Optimized workflow for behavior-coupled fiber photometry experiment: improved data navigation and accessibility Open
Fiber photometry provides crucial insights into cell population activity underlying behavior. While numerous open-source data analysis tools exist, few offer an automated workflow that streamlines the analysis of fiber photometry data alon…
View article: Functional expression of the T-type Cav3.2 calcium channel in female and male human dorsal root ganglion neurons
Functional expression of the T-type Cav3.2 calcium channel in female and male human dorsal root ganglion neurons Open
T-type/Cav3 calcium channels are key in neuronal excitability and pain processing with Cav3.2 being the prominent isoform in primary sensory neurons of the dorsal root ganglion (DRG). Cav3.2 pharmacological inhibition or gene silencing ind…
View article: Facilitation of Ca<sub>V</sub>3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia
Facilitation of Ca<sub>V</sub>3.2 channel gating in pain pathways reveals a novel mechanism of serum-induced hyperalgesia Open
The Ca V 3.2 isoform of T-type voltage-gated calcium channels plays a crucial role in regulating the excitability of nociceptive neurons; the endogenous molecules that modulate its activity, however, remain poorly understood. Here, we used…
View article: Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism
Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism Open
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder marked by social deficits, repetitive behaviors, and atypical sensory perception. The link between ASD and skin abnormalities, inducing itchiness, has never been investigated …
View article: Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG Neurons
Functional expression and sex dimorphism of the T-type Cav3.2 Calcium Channel in human DRG Neurons Open
T-type/Cav3 calcium channels are key in neuronal excitability and pain processing with Cav3.2 being the prominent isoform in primary sensory neurons of the dorsal root ganglion (DRG). Its pharmacological inhibition or gene silencing induce…
View article: T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain
T-type calcium channels participate in intrinsic and synaptic activity of PKCγ neurons of the dorsal horn of the spinal cord during chronic pain Open
The disinhibition of the excitatory PKCγ interneurons plays a central role during mechanical allodynia in the dorsal horn of the spinal cord, routing harmless information to nociceptive pathways. The T-type calcium channel Cav3.2, necessar…
View article: Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies
Harmonizing neuropathic pain research: outcomes of the London consensus meeting on peripheral tissue studies Open
Neuropathic pain remains difficult to treat, with drug development hampered by an incomplete understanding of the pathogenesis of the condition, as well as a lack of biomarkers. The problem is compounded by the scarcity of relevant human p…
View article: Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons
Parvalbumin gates chronic pain through the modulation of firing patterns in inhibitory neurons Open
Spinal cord dorsal horn inhibition is critical to the processing of sensory inputs, and its impairment leads to mechanical allodynia. How this decreased inhibition occurs and whether its restoration alleviates allodynic pain are poorly und…
View article: Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain
Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via CaV3.3 and CaV3.2 and Alleviates Allodynia in a Mouse Model of Acute Postsurgical Pain Open
Venom peptides have evolved to target a wide range of membrane proteins through diverse mechanisms of action and structures, providing promising therapeutic leads for diseases, including pain, epilepsy, and cancer, as well as unique probes…
View article: Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice
Induction of antiviral interferon-stimulated genes by neuronal STING promotes the resolution of pain in mice Open
Inflammation and pain are intertwined responses to injury, infection, or chronic diseases. While acute inflammation is essential in determining pain resolution and opioid analgesia, maladaptive processes occurring during resolution can lea…
View article: Induction of antiviral Interferon-Stimulated Genes (ISGs) by neuronal STING promotes the resolution of pain
Induction of antiviral Interferon-Stimulated Genes (ISGs) by neuronal STING promotes the resolution of pain Open
Inflammation and pain are intertwined responses to injury, infection, or chronic diseases. While acute inflammation is essential in determining pain resolution and opioid analgesia, maladaptive processes occurring during resolution can lea…
View article: Prolonged Piezo1 Activation Induces Cardiac Arrhythmia
Prolonged Piezo1 Activation Induces Cardiac Arrhythmia Open
The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback …
View article: Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa <sub>V</sub> 1.7 and hCa <sub>V</sub> 3 voltage‐gated channels
Pmu1a, a novel spider toxin with dual inhibitory activity at pain targets hNa <sub>V</sub> 1.7 and hCa <sub>V</sub> 3 voltage‐gated channels Open
Venom‐derived peptides targeting ion channels involved in pain are regarded as a promising alternative to current, and often ineffective, chronic pain treatments. Many peptide toxins are known to specifically and potently block established…
View article: Prolonged Piezo1 Activation Induces Cardiac Arrhythmia
Prolonged Piezo1 Activation Induces Cardiac Arrhythmia Open
The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the center of this system is the heart which must detect these changes and adjust its performance accordingly. Mechano-electric feedback …
View article: Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain
Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain Open
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supraspinal level is almost unknown. In the anterior pretectum (APT), a hub of connectivity of the somat…
View article: Author response: Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain
Author response: Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Cav3.2 T-ty…
View article: Role of T CD4<sup>+</sup> cells, macrophages, C‐low threshold mechanoreceptors and spinal Ca<sub>v</sub>3.2 channels in inflammation and related pain‐like symptoms in murine inflammatory models
Role of T CD4<sup>+</sup> cells, macrophages, C‐low threshold mechanoreceptors and spinal Ca<sub>v</sub>3.2 channels in inflammation and related pain‐like symptoms in murine inflammatory models Open
Background and Purpose T‐type calcium channels, mainly the Ca v 3.2 subtype, are important contributors to the nociceptive signalling pathway. We investigated their involvement in inflammation and related pain‐like symptoms. Experimental A…
View article: The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice
The impact of C-tactile low-threshold mechanoreceptors on affective touch and social interactions in mice Open
Affective touch is necessary for proper neurodevelopment and sociability. However, it remains unclear how the neurons innervating the skin detect affective and social behaviors. The C low-threshold mechanoreceptors (C-LTMRs), a specific po…
View article: The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain
The neuronal tyrosine kinase receptor ligand ALKAL2 mediates persistent pain Open
The anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase known for its oncogenic potential that is involved in the development of the peripheral and central nervous system. ALK receptor ligands ALKAL1 and ALKAL2 were recently fou…
View article: Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain
Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain Open
Cav3.2 T-type calcium channel is a major molecular actor of neuropathic pain in peripheral sensory neurons, but its involvement at the supra-spinal level is almost unknown. In the Anterior Pretectum (APT), a hub of connectivity of the soma…
View article: A Single-Cell View of Degeneration and Regeneration in the Mammalian Spinal Cord
A Single-Cell View of Degeneration and Regeneration in the Mammalian Spinal Cord Open
International audience
View article: A Cellular Taxonomy of the Adult Human Spinal Cord
A Cellular Taxonomy of the Adult Human Spinal Cord Open
The mammalian spinal cord functions as a community of glial and neuronal cell types to accomplish sensory processing, autonomic control, and movement; conversely, the dysfunction of these cell types following spinal cord injury or disease …
View article: Cav3.2 calcium channels involvement in inflammation and related pain-like symptoms in murine inflammatory models
Cav3.2 calcium channels involvement in inflammation and related pain-like symptoms in murine inflammatory models Open
Background and Purpose T-type calcium channels, mainly the Cav3.2 subtype, are important contributors to the nociceptive signaling pathway. We investigated their involvement in inflammation and related pain-like symptoms. Experimental Appr…
View article: The impact of C-Tactile Low threshold mechanoreceptors on affective touch and social interactions in mice
The impact of C-Tactile Low threshold mechanoreceptors on affective touch and social interactions in mice Open
Affective touch is necessary for proper neurodevelopment and sociability. However, it is still unclear how the neurons innervating the skin detect affective and social behaviours. To clarify this matter, we targeted a specific population o…