Emmanuel Futier
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View article: Perioperative hemodynamic optimization - Paediatrics
Perioperative hemodynamic optimization - Paediatrics Open
Nine guidelines, with a high degree of agreement between experts, on perioperative hemodynamic optimization have been formulated.
View article: Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury Open
Importance The effect of sodium bicarbonate infusion on outcome in patients with severe metabolic acidemia and moderate to severe acute kidney injury is unknown. Objective To determine whether sodium bicarbonate infusion is associated with…
View article: Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients: the 4D randomized clinical trial
Dexmedetomidine for treatment of hyperactive delirium in non-intubated ICU patients: the 4D randomized clinical trial Open
View article: Perioperative hemodynamic optimization - Adults including obstetrics
Perioperative hemodynamic optimization - Adults including obstetrics Open
24 guidelines on perioperative haemodynamic optimization have been formulated, with a high degree of agreement between experts.
View article: Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial
Personalized driving pressure-guided positive end-expiratory pressure in patients at risk of postoperative respiratory failure (IMPROVE-2): a multicenter, pragmatic, randomized clinical trial Open
View article: Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for a stepped-wedge cluster-randomised controlled trial
Prevention of extubation failure in neurocritical care patients with residual disorder of consciousness: the Brain-Injured Patients Extubation Readiness (BIPER) study protocol for a stepped-wedge cluster-randomised controlled trial Open
Introduction In the intensive care unit (ICU), brain-injured patients are frequently exposed to mechanical ventilation to protect the brain and preserve physiology. After intracranial pressure control and sedation withdrawal, this populati…
View article: Principes et utilisations de la pression œsophagienne. Mise au point
Principes et utilisations de la pression œsophagienne. Mise au point Open
View article: Temporal stability of inflammatory subphenotypes of acute respiratory distress syndrome: 28-day insights from the ICAR trial
Temporal stability of inflammatory subphenotypes of acute respiratory distress syndrome: 28-day insights from the ICAR trial Open
Inflammatory subphenotypes were stable in COVID-19-related ARDS, with few transitions over 28 days. Monitoring these subphenotypes could be valuable for assessing patient trajectories and treatment responses.
View article: Impact of tracheal extubation location after surgical procedures on peri‐operative times: a prospective dual‐centre observational study*
Impact of tracheal extubation location after surgical procedures on peri‐operative times: a prospective dual‐centre observational study* Open
Summary Introduction Extubation of the trachea in the operating theatre may increase the time spent there. Conversely, tracheal extubation in the post‐anaesthesia care unit may prolong the duration of anaesthesia and increase the incidence…
View article: Protocol publication rate and comparison between article, registry and protocol in RCTs
Protocol publication rate and comparison between article, registry and protocol in RCTs Open
View article: Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial
Weaning of non COPD patients at high-risk of extubation failure assessed by lung ultrasound: the WIN IN WEAN multicentre randomised controlled trial Open
View article: Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome
Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome Open
Background Trunk inclination in patients with Acute Respiratory Distress Syndrome (ARDS) in the supine position has gained scientific interest due to its effects on respiratory physiology, including mechanics, oxygenation, ventilation dist…
View article: Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery: a post hoc analysis of a randomized clinical trial Open
View article: Cost awareness among intensivists in their daily clinical practice: a prospective multicentre study
Cost awareness among intensivists in their daily clinical practice: a prospective multicentre study Open
Background Better cost-awareness is a prerogative in achieving the best benefit/risk/cost ratio in the care. We aimed to assess the cost-awareness of intensivists in their daily clinical practice and to identify factors associated with acc…
View article: Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery A post-hoc analysis of a Randomized Clinical Trial
Noninvasive ventilation on reintubation in patients with obesity and hypoxemic respiratory failure following abdominal surgery A post-hoc analysis of a Randomized Clinical Trial Open
Purpose Although noninvasive ventilation (NIV) may reduce reintubation in patients with acute hypoxemic respiratory failure following abdominal surgery, this strategy has not been specifically assessed in patients with obesity. Methods We …
View article: Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome
Physiological effects and safety of bed verticalization in patients with acute respiratory distress syndrome Open
Background Patient position, such as prone position, can improve prognosis in acute respiratory distress syndrome. Total verticalization is now possible using dedicated beds, but the feasibility, safety, and pulmonary or hemodynamic effect…
View article: Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review
Sample size estimation in clinical trials using ventilator-free days as the primary outcome: a systematic review Open
Background Ventilator-free days (VFDs) are a composite endpoint increasingly used as the primary outcome in critical care trials. However, because of the skewed distribution and competitive risk between components, sample size estimation r…
View article: Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial
Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial Open
View article: Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke
Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke Open
Importance General anesthesia and procedural sedation are common practice for mechanical thrombectomy in acute ischemic stroke. However, risks and benefits of each strategy are unclear. Objective To determine whether general anesthesia or …
View article: Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure
Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure Open
View article: Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial
Effect of non-invasive ventilation after extubation in critically ill patients with obesity in France: a multicentre, unblinded, pragmatic randomised clinical trial Open
View article: Ionized Magnesium: Interpretation and Interest in Atrial Fibrillation
Ionized Magnesium: Interpretation and Interest in Atrial Fibrillation Open
Background: Magnesium (Mg) is often used to manage de novo atrial fibrillation (AF) in the emergency department (ED) and intensive care unit (ICU). Point of care measurement of ionized magnesium (iMg) allows a rapid identification of patie…
View article: Use of volatile anesthetics for sedation in the ICU during the COVID-19 pandemic: A national survey in France (VOL’ICU 2 study)
Use of volatile anesthetics for sedation in the ICU during the COVID-19 pandemic: A national survey in France (VOL’ICU 2 study) Open
Background The COVID-19 pandemic has increased the number of patients in ICUs leading to a worldwide shortage of the intravenous sedative agents obligating physicians to find alternatives including inhaled sedation. Inhaled sedation in Fre…
View article: Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial
Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial Open
Objective To investigate whether oral antimicrobial prophylaxis as an adjunct to intravenous antibiotic prophylaxis reduces surgical site infections after elective colorectal surgery. Design Multicentre, randomised, double blind, placebo c…
View article: Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock
Association between proteinuria trajectories and outcomes in critically ill patients with sepsis or shock Open
Background Proteinuria results from kidney damage and can be a predictor of illness severity and mortality in the intensive care unit (ICU). However, the optimal timing of proteinuria measurements and the reference values remain undetermin…
View article: Impact of Macintosh blade size on endotracheal intubation success in intensive care units: a retrospective multicenter observational MacSize-ICU study
Impact of Macintosh blade size on endotracheal intubation success in intensive care units: a retrospective multicenter observational MacSize-ICU study Open
In the present study, Macintosh blade No3 was associated with improved first-passed DL in French ICUs. However, study design requires the conduct of a nationwide prospective multicenter randomized trial in different settings to confirm the…
View article: One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial
One-year patient outcomes based on lung morphology in acute respiratory distress syndrome: secondary analysis of LIVE trial Open
Background Acute respiratory distress syndrome (ARDS) has different phenotypes and distinct short-term outcomes. Patients with non-focal ARDS have a higher short-term mortality than focal ones. The aim of this study was to assess the impac…
View article: Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial
Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial Open
Preclinical studies have shown that volatile anesthetics may have beneficial effects on injured lungs, and pilot clinical data support improved arterial oxygenation, attenuated inflammation, and decreased lung epithelial injury in patients…
View article: Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021
Guidelines for the choice of intravenous fluids for vascular filling in critically ill patients, 2021 Open
Substantial agreement among experts has been obtained to provide a sizable number of recommendations aimed at optimising the choice of fluid therapy for resuscitation of critically ill patients.
View article: Intubation en réanimation en 2022 : quoi de neuf ?
Intubation en réanimation en 2022 : quoi de neuf ? Open