Emmanuel Mpolya
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View article: A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: A study protocol for open-label, randomized phase III trial (OptiRiMoxTB)
A pragmatic trial with an optimized dose of rifampicin and moxifloxacin for the treatment of drug-susceptible pulmonary tuberculosis: A study protocol for open-label, randomized phase III trial (OptiRiMoxTB) Open
Background Current combination antibiotic treatment for drug-susceptible tuberculosis (DS-TB) usually takes six months to complete. This long duration can compromise clinical outcomes. Although a four-month regimen including an optimized d…
View article: Seroprevalence and associated risk factors of selected arboviruses at Namanga and Mutukula cross-border areas in Tanzania
Seroprevalence and associated risk factors of selected arboviruses at Namanga and Mutukula cross-border areas in Tanzania Open
View article: Rifampicin Exposure in Tuberculosis Patients with Comorbidities in Sub-Saharan Africa: Prioritising Populations for Treatment—A Systematic Review and Meta-analysis
Rifampicin Exposure in Tuberculosis Patients with Comorbidities in Sub-Saharan Africa: Prioritising Populations for Treatment—A Systematic Review and Meta-analysis Open
Our results emphasise the need for individualised dosing and targeted TDM implementation among TB-HIV and TB-DM populations on rifampicin in SSA. Although all populations exhibited low Cmax levels, TB-HIV populations may be prio…
View article: Pulmonary rehabilitation for post-TB lung disease led by TB survivors
Pulmonary rehabilitation for post-TB lung disease led by TB survivors Open
BACKGROUNDPost-TB patients often experience persistent lung issues that impair exercise capacity and quality of life. Although pulmonary rehabilitation is known to be effective for chronic lung diseases, its role in post-TB lung disease re…
View article: Factors that Influenced the Delivery of a Community-Based Continuous Mass Dog Vaccination Approach in the Mara Region of Tanzania
Factors that Influenced the Delivery of a Community-Based Continuous Mass Dog Vaccination Approach in the Mara Region of Tanzania Open
View article: Factors that Influenced the Delivery of a Community-Based Continuous Mass Dog Vaccination Approach in the Mara Region of Tanzania
Factors that Influenced the Delivery of a Community-Based Continuous Mass Dog Vaccination Approach in the Mara Region of Tanzania Open
View article: Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021
Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021 Open
View article: Characterization of population connectivity for enhanced cross-border surveillance of yellow fever at Mutukula and Namanga borders in Tanzania
Characterization of population connectivity for enhanced cross-border surveillance of yellow fever at Mutukula and Namanga borders in Tanzania Open
View article: Seroprevalence and molecular analysis of yellow fever virus in mosquitoes at Namanga and Mutukula borders in Tanzania
Seroprevalence and molecular analysis of yellow fever virus in mosquitoes at Namanga and Mutukula borders in Tanzania Open
The overall YF seroprevalence was 12.5%, with higher rates among older individuals (7.0%) and female participants (immunoglobulin [Ig] G 4.4%, IgM 6.0%). Notably, YF virus RNA was detected in three out of 46 pools of 192 mosquitoes. The od…
View article: Prevalence of Taenia solium cysticercosis in domestic pigs following albendazole deworming intervention in rural communities of Mbulu district, Tanzania
Prevalence of Taenia solium cysticercosis in domestic pigs following albendazole deworming intervention in rural communities of Mbulu district, Tanzania Open
View article: Prevalence and Risk Factors of Human Taenia solium Cysticercosis in Mbulu District, Northern Tanzania
Prevalence and Risk Factors of Human Taenia solium Cysticercosis in Mbulu District, Northern Tanzania Open
Background: Taeniosis and cysticercosis are human infections caused by the pork tapeworm, Taenia solium. This study is a baseline for community-based intervention. We determined the prevalence of human cysticercosis and associated risk fac…
View article: HIV viral suppression and risk of viral rebound in patients on antiretroviral therapy: a two- year retrospective cohort study in Northern Tanzania
HIV viral suppression and risk of viral rebound in patients on antiretroviral therapy: a two- year retrospective cohort study in Northern Tanzania Open
Background The world is moving towards the third target of the Joint United Nations Programme on HIV/AIDS to ensure most people receiving antiretroviral therapy (ART) are virologically suppressed. Little is known about viral suppression at…
View article: Effectiveness of Point of Entry Health Screening Measures among Travelers in the Detection and Containment of the International Spread of COVID-19: A Review of the Evidence
Effectiveness of Point of Entry Health Screening Measures among Travelers in the Detection and Containment of the International Spread of COVID-19: A Review of the Evidence Open
COVID-19 remains a communicable disease with the capacity to cause substantial damage to health and health systems. Enhanced health screening at points of entry (POEs) is a public health measure implemented to support early detection, prev…
View article: Correlating food and nutritional patterns with cancers in the pediatric oncology population at two specialized hospitals in Tanzania
Correlating food and nutritional patterns with cancers in the pediatric oncology population at two specialized hospitals in Tanzania Open
View article: Factors associated with poor compliance to rabies post-exposure prophylaxis among dog bite victims in Maswa District in Tanzania: a cross-sectional study
Factors associated with poor compliance to rabies post-exposure prophylaxis among dog bite victims in Maswa District in Tanzania: a cross-sectional study Open
Introduction: administering rabies post-exposure prophylaxis (PEP) in a timely and appropriate manner remains the most fundamental measure for preventing human rabies. However, a number of barriers to accessing and completing PEP exist.
View article: Prevalence and Risk Factors of Human Taenia solium Cysticercosis in Mbulu District, Northern Tanzania
Prevalence and Risk Factors of Human Taenia solium Cysticercosis in Mbulu District, Northern Tanzania Open
Background: Taeniasis and cysticercosis are human infections caused by the pork tapeworm, Taenia solium. This study is a baseline for the Community-based intervention. We determined the prevalence of human cysticercosis and associated risk…
View article: PA-539 Developing hands-on skills on tuberculosis sponsor responsibilities and clinical trial management for END-TB in Sub-Saharan
PA-539 Developing hands-on skills on tuberculosis sponsor responsibilities and clinical trial management for END-TB in Sub-Saharan Open
Background The END TB strategy recommends scaling up of research training and capacity by growing the workforce of scientists in tuberculosis (TB) endemic settings skilled in "development and rapid uptake of new TB tools and "interventions…
View article: Integrating a community-based continuous mass dog vaccination delivery strategy into the veterinary system of Tanzania: A process evaluation using normalization process theory
Integrating a community-based continuous mass dog vaccination delivery strategy into the veterinary system of Tanzania: A process evaluation using normalization process theory Open
This work suggests that CBC-MDV has the potential to be integrated and sustained in the context of Tanzania. Involving communities in design, delivery and monitoring of CBC-MDV activities could contribute to improving and sustaining its ou…
View article: Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study
Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study Open
Background: Dog-mediated rabies is endemic across Africa causing thousands of human deaths annually. A One Health approach to rabies is advocated, comprising emergency post-exposure vaccination of bite victims and mass dog vaccination to b…
View article: Author response: Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study
Author response: Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study Open
View article: Factors Associated with Poor Compliance to Rabies Post-Exposure Prophylaxis Among Dog Bites Victims in Maswa District in Tanzania: A Cross-Sectional Study
Factors Associated with Poor Compliance to Rabies Post-Exposure Prophylaxis Among Dog Bites Victims in Maswa District in Tanzania: A Cross-Sectional Study Open
View article: Prevalence and risk factors of brain atrophy and associated confusion state among adults from three hospitals in northern Tanzania
Prevalence and risk factors of brain atrophy and associated confusion state among adults from three hospitals in northern Tanzania Open
there is high prevalence of brain atrophy and associated confusion state among hospitalized adults in northern Tanzania. Reported prognostic factors for brain atrophy such as age, smoking, alcohol consumption, hypertension, type-2 diabetes…
View article: Prevalence of Cysticercosis in Domestic Pigs in Rural Communities of Mbulu District, Tanzania
Prevalence of Cysticercosis in Domestic Pigs in Rural Communities of Mbulu District, Tanzania Open
View article: A prospective study of predictors of HIV viral load rebound in an HIV hyperendemic rural population of KwaZulu-Natal, South Africa
A prospective study of predictors of HIV viral load rebound in an HIV hyperendemic rural population of KwaZulu-Natal, South Africa Open
Introduction: globally, up to one third of people living with HIV had unsuppressed viral loads in 2020, making it imperative to understand the various predictors of HIV viral load rebound (HVLR) in specific hyperendemic subpopulations. The…
View article: A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore
A case-control study on the driving factors of childhood brain volume loss: What pediatricians must explore Open
Background The brain volume loss also known as brain atrophy is increasingly observed among children in the course of performing neuroimaging using CT scan and MRI brains. While severe forms of brain volume loss are frequently associated w…
View article: Participatory development of practical, affordable, insecticide-treated mosquito proofing for a range of housing designs in rural southern Tanzania
Participatory development of practical, affordable, insecticide-treated mosquito proofing for a range of housing designs in rural southern Tanzania Open
View article: Participation in mass dog vaccination campaigns in Tanzania: Benefits of community engagement
Participation in mass dog vaccination campaigns in Tanzania: Benefits of community engagement Open
Background Canine rabies causes about 59,000 human deaths each year globally but the disease can be eliminated by sustaining sufficient dog vaccination coverage over several consecutive years. A challenge to achieving high coverage is low …
View article: Development, feasibility and potential effectiveness of community-based continuous mass dog vaccination delivery strategies: Lessons for optimization and replication
Development, feasibility and potential effectiveness of community-based continuous mass dog vaccination delivery strategies: Lessons for optimization and replication Open
Objectives Dog vaccination can eliminate rabies in dogs, but annual delivery strategies do not sustain vaccination coverage between campaigns. We describe the development of a community-based continuous mass dog vaccination (CBC-MDV) appro…
View article: Impact of early diagnosis of impaired glucose regulation in tuberculosis: Comparison of clinical outcomes in people with tuberculosis in Tanzania
Impact of early diagnosis of impaired glucose regulation in tuberculosis: Comparison of clinical outcomes in people with tuberculosis in Tanzania Open
Objective Diabetes mellitus (DM) has been known to compromise tuberculosis (TB) treatment outcomes. Association data are limited for early hyperglycaemia detection and TB treatment outcomes. Thus, we assessed treatment outcomes including t…
View article: Prevalence and Predictors of Antibiotic Prescriptions at Primary Healthcare Facilities in the Dodoma Region, Central Tanzania: A Retrospective, Cross-Sectional Study
Prevalence and Predictors of Antibiotic Prescriptions at Primary Healthcare Facilities in the Dodoma Region, Central Tanzania: A Retrospective, Cross-Sectional Study Open
Background: Accelerated by the misuse or overuse of antibiotics, antibiotic resistance remains a global public health threat. We report the prevalence and predictors of antibiotic prescriptions in primary healthcare facilities in Dodoma, T…