Emmanuel Sampene
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View article: Hypocarnitinemia and its effect on seizure control in adult patients with intractable epilepsy on the modified Atkins diet
Hypocarnitinemia and its effect on seizure control in adult patients with intractable epilepsy on the modified Atkins diet Open
Introduction Previous studies have demonstrated the safety and efficacy of the modified Atkins diet (MAD) in attenuating seizures in patients with intractable epilepsy. MAD works by achieving ketosis, which is heavily dependent on the meta…
View article: Supplemental Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC
Supplemental Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC Open
Supplemental Data
View article: Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC
Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC Open
Head and neck squamous cell carcinomas (HNSCC) are frequently altered along the PI3K/AKT/mTORC signaling axis. Despite excellent preclinical data, the use of compounds targeting this pathway as monotherapy has been underwhelming in initial…
View article: Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC
Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC Open
Head and neck squamous cell carcinomas (HNSCC) are frequently altered along the PI3K/AKT/mTORC signaling axis. Despite excellent preclinical data, the use of compounds targeting this pathway as monotherapy has been underwhelming in initial…
View article: Supplemental Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC
Supplemental Data from Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC Open
Supplemental Data
View article: Supplemental Figures 1-3, Supplementary Tables 1-2 from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition
Supplemental Figures 1-3, Supplementary Tables 1-2 from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition Open
Table S1. List of antibodies used, sources, and application specific details; Table S2. Short tandem repeat loci with patient, passage 1 and passage 5 reads; Figure S1: MYB-NFIB fusion testing ACC patient tumor and PDX; Figure S2: XRT and …
View article: Supplemental Figures 1-3, Supplementary Tables 1-2 from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition
Supplemental Figures 1-3, Supplementary Tables 1-2 from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition Open
Table S1. List of antibodies used, sources, and application specific details; Table S2. Short tandem repeat loci with patient, passage 1 and passage 5 reads; Figure S1: MYB-NFIB fusion testing ACC patient tumor and PDX; Figure S2: XRT and …
View article: Data from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition
Data from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition Open
Purpose: Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and neck. There are currently no approved systemic agents or known radiosensitizers for ACC. Unlike the more…
View article: Data from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition
Data from Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition Open
Purpose: Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and neck. There are currently no approved systemic agents or known radiosensitizers for ACC. Unlike the more…
View article: Dysphagia Profiles Among Inpatients with Dementia Referred for Swallow Evaluation
Dysphagia Profiles Among Inpatients with Dementia Referred for Swallow Evaluation Open
Background: Alzheimer’s disease and related dementias (ADRD) patients who are hospitalized often develop oropharyngeal dysphagia, increasing risk for adverse outcomes, such as aspiration pneumonia. However, prevalence estimates of dysphagi…
View article: Feline cutaneous lymphoma: an evaluation of disease presentation and factors affecting response to treatment
Feline cutaneous lymphoma: an evaluation of disease presentation and factors affecting response to treatment Open
Objectives The primary goal of this study was to characterize the clinical presentation of feline cutaneous lymphoma. The secondary aims included determining if treatment or initial response to treatment affected the overall survival of pa…
View article: Impact of a Rheumatology Clinic Protocol on Tobacco Cessation Quit Line Referrals
Impact of a Rheumatology Clinic Protocol on Tobacco Cessation Quit Line Referrals Open
Objective Smoking increases cardiopulmonary and rheumatic disease risk, yet tobacco cessation intervention is rare in rheumatology clinics. This study aimed to implement a rheumatology staff‐driven protocol, Quit Connect, to increase the r…
View article: Impact of a problem-oriented view on clinical data retrieval
Impact of a problem-oriented view on clinical data retrieval Open
Objective The electronic health record (EHR) data deluge makes data retrieval more difficult, escalating cognitive load and exacerbating clinician burnout. New auto-summarization techniques are needed. The study goal was to determine if pr…
View article: Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome
Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome Open
A large number of adults and children consume soy in various forms, but little information is available regarding potential neurological side effects. Prior work indicates an association between the consumption of soy-based diets and seizu…
View article: Accuracy of Self-Reported Vaccination Status in a Cohort of Patients with Inflammatory Bowel Disease
Accuracy of Self-Reported Vaccination Status in a Cohort of Patients with Inflammatory Bowel Disease Open
View article: Physician Burnout and Timing of Electronic Health Record Use
Physician Burnout and Timing of Electronic Health Record Use Open
Background Rates of burnout among physicians have been high in recent years. The electronic health record (EHR) is implicated as a major cause of burnout. Objective This article aimed to determine the association between physician burnout …
View article: Association of Sjögren's Syndrome With Reduced Lifetime Sex Hormone Exposure: A Case–Control Study
Association of Sjögren's Syndrome With Reduced Lifetime Sex Hormone Exposure: A Case–Control Study Open
Objective To test whether cumulative estrogen exposure, as determined by age at menarche, age at menopause, female hormone use, hysterectomy, and parity, have an effect on the development of primary Sjögren's syndrome ( SS ). Methods We pe…
View article: Operative Vaginal Delivery Is a Safe Option in Women Undergoing a Trial of Labor after Cesarean
Operative Vaginal Delivery Is a Safe Option in Women Undergoing a Trial of Labor after Cesarean Open
Objective To compare outcomes of operative intervention in the second stage of labor during trial of labor after cesarean (TOLAC). Study Design A secondary analysis of the Maternal-Fetal Medicine Units Network cesarean section registry was…
View article: Nutrition and Exercise Strategies to Prevent Excessive Pregnancy Weight Gain: A Meta-analysis
Nutrition and Exercise Strategies to Prevent Excessive Pregnancy Weight Gain: A Meta-analysis Open
Objective To evaluate nutrition-only, exercise-only, and nutrition-plus-exercise interventions for optimizing gestational weight gain (GWG) based on the 2009 Institute of Medicine (IOM) guidelines. Study PubMed, Google Scholar, and 2015 Co…
View article: Mycophenolate therapy in interstitial pneumonia with autoimmune features: a cohort study
Mycophenolate therapy in interstitial pneumonia with autoimmune features: a cohort study Open
Patients with IPAF might benefit from mycophenolate therapy. Larger prospective clinical trials are needed to evaluate the efficacy of mycophenolate for patients who meet criteria for IPAF.
View article: Neoadjuvant chemotherapy is associated with a high rate of perioperative blood transfusion at the time of interval cytoreductive surgery
Neoadjuvant chemotherapy is associated with a high rate of perioperative blood transfusion at the time of interval cytoreductive surgery Open
View article: Seasonal and Geographic Patterns in Seeking Cardiovascular Health Information: An Analysis of the Online Search Trends
Seasonal and Geographic Patterns in Seeking Cardiovascular Health Information: An Analysis of the Online Search Trends Open
View article: Comparing appropriateness of antibiotics for nursing home residents by setting of prescription initiation: a cross-sectional analysis
Comparing appropriateness of antibiotics for nursing home residents by setting of prescription initiation: a cross-sectional analysis Open
View article: Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin
Oxidative stress via inhibition of the mitochondrial electron transport and Nrf-2-mediated anti-oxidative response regulate the cytotoxic activity of plumbagin Open
Plumbagin, an anti-cancer agent, is toxic to cells of multiple species. We investigated if plumbagin targets conserved biochemical processes. Plumbagin induced DNA damage and apoptosis in cells of diverse mutational background with compara…
View article: Additional file 1: of Neoadjuvant chemotherapy is associated with a high rate of perioperative blood transfusion at the time of interval cytoreductive surgery
Additional file 1: of Neoadjuvant chemotherapy is associated with a high rate of perioperative blood transfusion at the time of interval cytoreductive surgery Open
“Deidentified raw clinical data”. Raw clinical data, “Deidentified raw clinical data” includes all of the raw data used for analysis in the above study. (XLSX 17 kb)
View article: Improved conditional imputation for linear regression with a randomly censored predictor
Improved conditional imputation for linear regression with a randomly censored predictor Open
This article describes a nonparametric conditional imputation analytic method for randomly censored covariates in linear regression. While some existing methods make assumptions about the distribution of covariates or underestimate standar…
View article: Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition
Radiosensitization of Adenoid Cystic Carcinoma with MDM2 Inhibition Open
Purpose: Adenoid cystic carcinoma (ACC) is a rare cancer arising from the major or minor salivary gland tissues of the head and neck. There are currently no approved systemic agents or known radiosensitizers for ACC. Unlike the more common…
View article: Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC
Cotargeting mTORC and EGFR Signaling as a Therapeutic Strategy in HNSCC Open
Head and neck squamous cell carcinomas (HNSCC) are frequently altered along the PI3K/AKT/mTORC signaling axis. Despite excellent preclinical data, the use of compounds targeting this pathway as monotherapy has been underwhelming in initial…
View article: Acute Fetal Demise with First Trimester Maternal Infection Resulting from <i>Listeria monocytogenes</i> in a Nonhuman Primate Model
Acute Fetal Demise with First Trimester Maternal Infection Resulting from <i>Listeria monocytogenes</i> in a Nonhuman Primate Model Open
Infection with Listeria monocytogenes during pregnancy is associated with miscarriage, preterm birth, and neonatal complications, including sepsis and meningitis. While the risk of these conditions is thought to be greatest during the thir…