Explanipedia

Air pollution, greenspace, and metabolic syndrome in older Czech and Swiss populations Open

Andrea Dalecká, Ayoung Jeong, Dániel Szabó, Bálint Tamási, Medea Imboden , et al. · 2025

Background: The prevalence of metabolic syndrome (MetS) has increased rapidly, with considerable variation between European countries. The study examined the relationship between air pollutants, greenspace, and MetS and its components in t…

Methods and exploratory findings of the first Swiss agricultural health cohort FarmCoSwiss Open

Julia Doetzer, Priska Ammann, Medea Imboden, Karin Ingold, Ayoung Jeong , et al. · 2025

FarmCoSwiss is Switzerland’s first agricultural cohort study on farmers’ health and wellbeing. It aims to longitudinally describe farmers’ mental and physical health and identify risk and protective factors. Between November 2022 and Augus…

FarmCoSwiss: The first Swiss agricultural health cohort Open

Julia Doetzer, Priska Ammann, Medea Imboden, Karin Ingold, Ayoung Jeong , et al. · 2024

FarmCoSwiss is Switzerland's first agricultural cohort study on farmers’ health and wellbeing. It aims to longitudinally describe farmers’ mental and physical health and identify risk and protective factors. Between November 2022 and Augus…

Participation in organised sports and longitudinal development of physical activity in Swiss youth: the population-based SOPHYA cohort Open

Johanna Hänggi, Gianfranco Lovison, Ayoung Jeong, Emmanuel Schaffner, Emil Njihuis , et al. · 2024

BACKGROUND: Maintaining physical activity throughout life is crucial for overall health and wellbeing. Yet the age-related decline in average physical activity, a natural phenomenon also observed in animals, poses a challenge. This study a…

Removable dental prostheses and difficulties with chewing among frail individuals: Results from the Swiss SAPALDIA cohort Open

Lujain Alchalabi, Emmanuel Schaffner, Medea Imboden, Julia C. Difloe‐Geisert, Nicola U. Zitzmann , et al. · 2024

Oral healthcare among the frail is an underestimated geriatric care element. While neglected oral health (OH) is a well-established risk factor for frailty, frailty can be a risk factor for subsequent OH problems. The cross-sectional inves…

Cross-Sectional but Not Prospective Association of Accelerometry-Derived Physical Activity With Quality of Life in Children and Adolescents Open

Ranin Darkhawaja, Jürgen Hänggi, Emmanuel Schaffner, Marek Kwiatkowski, Abdulsalam Alkaiyat , et al. · 2024

Objectives: This study aims to quantify the cross-sectional and prospective associations between quality of life (QoL) and moderate-to-vigorous physical activity (MVPA). Methods: This study was based on the Swiss children’s Objectively mea…

Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency Open

Sébastien Thériault, Medea Imboden, Mary L. Biggs, Thomas R. Austin, Stefanie Aeschbacher , et al. · 2022

Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci …

The neighborhood environment and its association with the spatio-temporal footprint of tobacco consumption and changes in smoking-related behaviors in a Swiss urban area Open

Juan R. Vallarta‐Robledo, Pedro Marques‐Vidal, José Luís Sandoval, David De Ridder, Emmanuel Schaffner , et al. · 2022

Depression and cardiovascular disease are not linked by high blood pressure: findings from the SAPALDIA cohort Open

Katrina Obas, Marek Kwiatkowski, Emmanuel Schaffner, Undine E. Lang, Daiana Stolz , et al. · 2022

Depression and cardiovascular disease (CVD) are main contributors to the global disease burden and are linked. Pathophysiological pathways through increased blood pressure (BP) are a common focus in studies aiming to explain the relationsh…

Spatial clusters of daily tobacco consumption before and after a smoke-free policy implementation Open

Juan R. Vallarta‐Robledo, José Luís Sandoval, David De Ridder, Anaïs Ladoy, Pedro Marques‐Vidal , et al. · 2021

This study assessed the spatial dependence of daily tobacco consumption and how it is spatially impacted by individual and neighborhood socioeconomic determinants, and tobacco consumption facilities before and after a smoke-free implementa…

Perceived built environment, health-related quality of life and health care utilization Open

Paco Cerletti, Ikenna C. Eze, Dirk Keidel, Emmanuel Schaffner, Daiana Stolz , et al. · 2021

Previous research has shown that the built environment plays a crucial role for health-related quality of life (HRQoL) and health care utilization. But, there is limited evidence on the independence of this association from lifestyle and s…

Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study Open

Ikenna C. Eze, María Foraster, Emmanuel Schaffner, Danielle Vienneau, Reto Pieren , et al. · 2020

Prospective evidence on the risk of depression in relation to transportation noise exposure and noise annoyance is limited and mixed. We aimed to investigate the associations of long-term exposure to source-specific transportation noise an…

The independent association of source-specific transportation noise exposure, noise annoyance and noise sensitivity with health-related quality of life Open

Paco Cerletti, Ikenna C. Eze, Emmanuel Schaffner, María Foraster, Danielle Viennau , et al. · 2020

Patterns of cross-sectional and predictive physical activity in Swiss adults aged 52+: results from the SAPALDIA cohort Open

Nicola Julia Aebi, Bettina Bringolf‐Isler, Emmanuel Schaffner, Seraina Caviezel, Medea Imboden , et al. · 2020

BACKGROUND Non-communicable diseases (NCDs) account for the vast majority of deaths in Switzerland. Insufficient physical activity (PA) is an established NCD risk factor and PA is known to be beneficial for physical and mental wellbeing. S…

Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study Open

André F.S. Amaral, Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, Cosetta Minelli , et al. · 2020

Regular Physical Activity Levels and Incidence of Restrictive Spirometry Pattern: A Longitudinal Analysis of 2 Population-Based Cohorts Open

Anne‐Elie Carsin, Dirk Keidel, Elaine Fuertes, Medea Imboden, Joost Weyler , et al. · 2020

We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and physical activity were assessed in 2 populati…

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study Open

Ikenna C. Eze, Ayoung Jeong, Emmanuel Schaffner, Faisal I. Rezwan, Akram Ghantous , et al. · 2020

Mutually independent DNA methylation was associated with source-specific transportation noise and air pollution exposures, with distinct and shared enrichments for pathways related to inflammation, cellular development, and immune response…

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study (Supplementary Data) Open

Ikenna C. Eze, Ayoung Jeong, Emmanuel Schaffner, Faisal I. Rezwan, Akram Ghantous , et al. · 2020

The zip file contains supplementary data for the publication - Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study, accepted for publication i…

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study (Supplementary Data) Open

Ikenna C. Eze, Ayoung Jeong, Emmanuel Schaffner, Faisal I. Rezwan, Akram Ghantous , et al. · 2020

The zip file contains supplementary data for the publication - Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study, accepted for publication i…

Data from: Epigenome-wide association study of lung function level and its change Open

Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, André F.S. Amaral, Emmanuel Schaffner , et al. · 2019

Previous reports link differential DNA methylation (DNAme) to environmental exposures which are associated with lung function. Direct evidence on lung function DNAme is however limited. We undertook an agnostic epigenome-wide association s…

Epigenome-wide association study of lung function level and its change Open

Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, André F.S. Amaral, Emmanuel Schaffner , et al. · 2019

Previous reports link differential DNA methylation (DNAme) to environmental exposures that are associated with lung function. Direct evidence on lung function DNAme is, however, limited. We undertook an agnostic epigenome-wide association …

Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects Open

Delphine Meier-Girard, Edgar Delgado‐Eckert, Emmanuel Schaffner, Christian Schindler, Nino Künzli , et al. · 2019

This study suggests that long-term exposure to TPM₁₀ triggers adverse changes in the regulation of the cardiovascular system. These adverse effects were more visible in the subjects without cardiovascular disease, in whom the ov…

Façades, floors and maps – Influence of exposure measurement error on the association between transportation noise and myocardial infarction Open

Danielle Vienneau, Harris Héritier, María Foraster, Ikenna C. Eze, Emmanuel Schaffner , et al. · 2018

Restrictive spirometry pattern is associated with low physical activity levels. A population based international study Open

Anne‐Elie Carsin, Elaine Fuertes, Emmanuel Schaffner, Deborah Jarvis, Josep M. Antó , et al. · 2018

Long-term exposure to transportation noise and its association with adiposity markers and development of obesity Open

María Foraster, Ikenna C. Eze, Danielle Vienneau, Emmanuel Schaffner, Ayoung Jeong , et al. · 2018

Transportation noise exposure, noise annoyance and respiratory health in adults: A repeated-measures study Open

Ikenna C. Eze, María Foraster, Emmanuel Schaffner, Danielle Vienneau, Harris Héritier , et al. · 2018

Transportation noise leads to sleep disturbance and to psychological and physiological sustained stress reactions, which could impact respiratory health. However, epidemiologic evidence on associations of objective transportation noise exp…

A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland Open

Harris Héritier, Danielle Vienneau, María Foraster, Ikenna C. Eze, Emmanuel Schaffner , et al. · 2018

Our study suggests that transportation noise is associated with MI mortality, independent from air pollution. Air pollution studies not adequately adjusting for transportation noise exposure may overestimate the cardiovascular disease burd…

Body mass index and lung function: A two-step epigenetic Mendelian randomization study Open

André F.S. Amaral, Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, Cosetta Minelli , et al. · 2018

Background: A Mendelian randomisation (MR) study and longitudinal studies have reported the association of lung function with body mass index (BMI). Aim: To investigate whether the association of lung function with BMI is med…

SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts Open

Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, André F.S. Amaral , et al. · 2018

Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study Open

Alessandro Marcon, Francesca Locatelli, Dirk Keidel, Anna Beckmeyer-Borowko, Isa Cerveri , et al. · 2018

Background It has been debated, but not yet established, whether increased airway responsiveness can predict COPD. Recognising this link may help in identifying subjects at risk. Objective We studied prospectively whether airway responsive…

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