Emmeline Ayers
YOU?
Author Swipe
View article: Apathy Is Associated with Slower Gait and Subjective Cognitive Complaints in a South Indian Community-Dwelling Cohort
Apathy Is Associated with Slower Gait and Subjective Cognitive Complaints in a South Indian Community-Dwelling Cohort Open
Background/Objectives: Apathy is an independent risk factor for dementia and motoric–cognitive risk syndrome (MCR), a predementia syndrome characterized by slow gait and subjective cognitive complaints (SCCs). Our objective is to assess th…
View article: Migration Effects on Cognition: Protocol for the Aging in Kerala Americans Research Study (Preprint)
Migration Effects on Cognition: Protocol for the Aging in Kerala Americans Research Study (Preprint) Open
BACKGROUND In the United States, Asian Americans represent the fastest growing population group, and are highly diverse linguistically, culturally, and demographically. However, in most national studies, Asian American groups are aggregat…
View article: Discovering subtypes with imaging signatures in the Motoric Cognitive Risk Syndrome Consortium using weakly supervised clustering
Discovering subtypes with imaging signatures in the Motoric Cognitive Risk Syndrome Consortium using weakly supervised clustering Open
INTRODUCTION Understanding the heterogeneity of brain structure in individuals with the Motoric Cognitive Risk Syndrome (MCR) may improve the current risk assessments of dementia. METHODS We used data from six cohorts from the MCR consorti…
View article: A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults
A Frailty‐Based Plasma Proteomic Signature Capturing Overall Health and Well‐Being in Older Adults Open
Frailty is an age‐related syndrome characterized by an increased vulnerability to adverse health outcomes in the face of stressors. By deriving a blood‐based proteomic signature for frailty, the current study aimed to enhance the understan…
View article: Diminished Social and Leisure Engagement in Community Dwelling-Older Adults with Apathy
Diminished Social and Leisure Engagement in Community Dwelling-Older Adults with Apathy Open
Background: Apathy predicts functional and cognitive decline in community-dwelling older adults. However, the behavioral correlates of apathy, which could promote cognitive decline have not been described. Our objective was to investigate …
View article: Daily Diary Smartphone Assessment of Subjective Cognitive Concerns in Motoric Cognitive Risk Syndrome: A Pilot Study
Daily Diary Smartphone Assessment of Subjective Cognitive Concerns in Motoric Cognitive Risk Syndrome: A Pilot Study Open
Background and Aims Motoric cognitive risk syndrome (MCR), a predementia condition that combines slow gait speed and subjective cognitive concerns (SCC), has broad diagnostic accessibility in resource poor settings as it is inexpensive and…
View article: Comparison of Gait Parameters Collected Across Two Commercially Available Gait Systems in Older Adults
Comparison of Gait Parameters Collected Across Two Commercially Available Gait Systems in Older Adults Open
Background/Objectives: Research examining mobility in older adults often utilizes spatiotemporal gait parameters obtained from computerized walkway systems like GAITRite (Franklin, NY, USA) and Zenometrics, LLC (Peekskill, NY, USA). Howeve…
View article: Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial
Improving Early Dementia Detection Among Diverse Older Adults With Cognitive Concerns With the 5-Cog Paradigm: Protocol for a Hybrid Effectiveness-Implementation Clinical Trial Open
Background The 5-Cog paradigm is a 5-minute brief cognitive assessment coupled with a clinical decision support tool designed to improve clinicians’ early detection of cognitive impairment, including dementia, in their diverse older primar…
View article: Visual‐somatosensory integration as a novel behavioral marker of amyloid pathology
Visual‐somatosensory integration as a novel behavioral marker of amyloid pathology Open
INTRODUCTION The ability to integrate information across sensory modalities is a vital aspect of everyday functioning and is linked to cognition. Increasing evidence suggests that Alzheimer's disease (AD) pathology manifests in sensory ass…
View article: The Potential of Non‐invasive Neurostimulation, tDCS for Cognitive Decline in Alzheimer’s Disease: Through the Lens of an Ongoing Clinical Trial
The Potential of Non‐invasive Neurostimulation, tDCS for Cognitive Decline in Alzheimer’s Disease: Through the Lens of an Ongoing Clinical Trial Open
Background Transcranial direct current stimulation (tDCS) is a non‐invasive neuromodulation method. Short‐term tDCS protocols have shown positive effects on cognitive outcomes in Alzheimer’s Disease (AD) populations 1‐5 . Less is known abo…
View article: Visual‐Somatosensory Integration: A novel behavioral marker of preclinical Alzheimer’s disease?
Visual‐Somatosensory Integration: A novel behavioral marker of preclinical Alzheimer’s disease? Open
Background Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas well before appearing in neural regions involved in higher‐order cognitive functions, such as memory. The ability to successfully integr…
View article: Psychological predictors of incident subjective cognitive complaints in community dwelling older adults
Psychological predictors of incident subjective cognitive complaints in community dwelling older adults Open
In this longitudinal analysis of community dwelling older adults, apathy was associated with an increased risk of SCC, when adjusting for cognition but not dysphoria. Finally, this study highlights apathy as an early risk factor, which may…
View article: Translation and Validation of the Malayalam Version of the Subjective Happiness Scale
Translation and Validation of the Malayalam Version of the Subjective Happiness Scale Open
View article: Correction: Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study
Correction: Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study Open
[This corrects the article DOI: 10.2196/56726.].
View article: Discovering Subtypes with Imaging Signatures in the Motoric Cognitive Risk Syndrome Consortium using Weakly-Supervised Clustering
Discovering Subtypes with Imaging Signatures in the Motoric Cognitive Risk Syndrome Consortium using Weakly-Supervised Clustering Open
STRUCTURED ABSTRACT INTRODUCTION Understanding the heterogeneity of brain structure in individuals with the Motoric Cognitive Risk Syndrome (MCR) may improve the current risk assessments of dementia. METHODS We used data from 6 cohorts fro…
View article: Validation of a Malayalam Version of the Apathy Evaluation Scale
Validation of a Malayalam Version of the Apathy Evaluation Scale Open
Background: The apathy evaluation scale (AES) measures apathy, but its usefulness as a screening tool in diverse populations is limited without translation into more languages. To date, there is no reported translation of the AES into Mala…
View article: Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial
Non-literacy biased, culturally fair cognitive detection tool in primary care patients with cognitive concerns: a randomized controlled trial Open
View article: Elevated Blood Homocysteine Increases the Risk of Incident Motoric Cognitive Risk Syndrome: A Two-Cohort Study
Elevated Blood Homocysteine Increases the Risk of Incident Motoric Cognitive Risk Syndrome: A Two-Cohort Study Open
Background Motoric Cognitive Risk (MCR) syndrome, a predementia syndrome characterized by cognitive complaints and slow gait, may have an underlying vascular etiology. Elevated blood levels of homocysteine, a known vascular risk factor, ha…
View article: Plasma proteomic profile of abdominal obesity in older adults
Plasma proteomic profile of abdominal obesity in older adults Open
Objective This study examines the plasma proteomic profile of abdominal obesity in older adults. Methods The association of abdominal obesity (waist circumference [WC]) with 4265 plasma proteins identified using the SomaScan Assay was exam…
View article: Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study
Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study Open
Background Progressive difficulty in performing everyday functional activities is a key diagnostic feature of dementia syndromes. However, not much is known about the neural signature of functional decline, particularly during the very ear…
View article: Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study (Preprint)
Linking Dementia Pathology and Alteration in Brain Activation to Complex Daily Functional Decline During the Preclinical Dementia Stages: Protocol for a Prospective Observational Cohort Study (Preprint) Open
BACKGROUND Progressive difficulty in performing everyday functional activities is a key diagnostic feature of dementia syndromes. However, not much is known about the neural signature of functional decline, particularly during the very ea…
View article: Is the Montreal cognitive assessment culturally valid in a diverse geriatric primary care setting? Lessons from the Bronx
Is the Montreal cognitive assessment culturally valid in a diverse geriatric primary care setting? Lessons from the Bronx Open
Background Efficacy and validity of the MoCA for cognitive screening in ethnoculturally and linguistically diverse settings is unclear. We sought to examine the utility and discriminative validity of the Spanish and English MoCA versions t…
View article: Prodromal Motoric Cognitive Risk Syndrome and Everyday Function
Prodromal Motoric Cognitive Risk Syndrome and Everyday Function Open
Background: Motoric cognitive risk syndrome (MCR), a pre-dementia syndrome characterized by subjective cognitive complaints and slow gait, is associated with disability in instrumental activities of daily living. It is unknown whether thes…
View article: Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study
Epidemiology of Motoric Cognitive Risk Syndrome in the Kerala Einstein Study: Protocol for a Prospective Cohort Study Open
Background The southern India state of Kerala has among the highest proportion of older adults in its population in the country. An increase in chronic age-related diseases such as dementia is expected in the older Kerala population. Ident…
View article: PHASE 1 TRIAL OF KT‐413, A DEGRADER OF IRAK4 AND IMID SUBSTRATES, IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B‐CELL NON‐HODGKIN’S LYMPHOMAS
PHASE 1 TRIAL OF KT‐413, A DEGRADER OF IRAK4 AND IMID SUBSTRATES, IN ADULT PATIENTS WITH RELAPSED OR REFRACTORY B‐CELL NON‐HODGKIN’S LYMPHOMAS Open
Background: Oncogenic mutations in myeloid differentiation primary response 88 (MYD88) occur in about 25% of diffuse large B-cell lymphoma (DLBCL), including approximately one-third of activated B-cell (ABC) nodal DLBCL and 70-80% of ABC-l…
View article: Biological Age Acceleration and Motoric Cognitive Risk Syndrome
Biological Age Acceleration and Motoric Cognitive Risk Syndrome Open
Objective Motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and subjective cognitive concerns, is associated with multiple age‐related risk factors. We hypothesized that MCR is associated with biologi…
View article: Randomized Controlled Trial of Social Ballroom Dancing and Treadmill Walking: Preliminary Findings on Executive Function and Neuroplasticity From Dementia-at-Risk Older Adults
Randomized Controlled Trial of Social Ballroom Dancing and Treadmill Walking: Preliminary Findings on Executive Function and Neuroplasticity From Dementia-at-Risk Older Adults Open
This randomized controlled trial (NCT03475316) examined the relative efficacy of 6 months of social ballroom dancing and treadmill walking on a composite executive function score, generated from digit symbol substitution test, flanker inte…
View article: Age-related changes in gait domains: Results from the LonGenity study
Age-related changes in gait domains: Results from the LonGenity study Open
View article: EVERYDAY FUNCTION PROFILES IN PRODROMAL STAGES OF MOTORIC COGNITIVE RISK SYNDROME: A PROSPECTIVE COHORT STUDY
EVERYDAY FUNCTION PROFILES IN PRODROMAL STAGES OF MOTORIC COGNITIVE RISK SYNDROME: A PROSPECTIVE COHORT STUDY Open
Assessment of everyday function is crucial to diagnosing pre-dementia and dementia syndromes in older individuals. Prodromal stages of mild cognitive impairment (MCI) are associated with mild limitations in complex activities of daily livi…
View article: ASSOCIATIONS BETWEEN POSTURAL SWAY AND GAIT DOMAINS DURING WALKING WHILE TALKING
ASSOCIATIONS BETWEEN POSTURAL SWAY AND GAIT DOMAINS DURING WALKING WHILE TALKING Open
Poor gait performance during walking-while-talking (WWT) is associated with an increased falls risk. Whether this association between WWT and falls is moderated by balance is not known. To address this, we examined 1) cross-sectional assoc…