Emmette R. Hutchison
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View article: Common methodological pitfalls in ICI pneumonitis risk prediction studies
Common methodological pitfalls in ICI pneumonitis risk prediction studies Open
Background Pneumonitis is one of the most common adverse events induced by the use of immune checkpoint inhibitors (ICI), accounting for a 20% of all ICI-associated deaths. Despite numerous efforts to identify risk factors and develop pred…
View article: Machine Learning Enabled Non-invasive Diagnosis of Nonalcoholic Fatty Liver Disease and Assessment of Abdominal Fat from MRI Data
Machine Learning Enabled Non-invasive Diagnosis of Nonalcoholic Fatty Liver Disease and Assessment of Abdominal Fat from MRI Data Open
Nonalcoholic fatty liver disease (NAFLD) is the most rapidly growing contributor to chronic liver disease worldwide with high disease burden and suffers from limitations in diagnosis. Inspired by recent advances in machine learning digital…
View article: Modeling Clinical Trial Attrition Using Machine Intelligence: A driver analytics case study using 1,325 trials representing one million patients
Modeling Clinical Trial Attrition Using Machine Intelligence: A driver analytics case study using 1,325 trials representing one million patients Open
The amount of time and resources invested in bringing novel therapeutics to market has increased year over year with fewer successful treatments reaching patients. In the lifecycle of drug development, the clinical phase is a major contrib…
View article: Correction to: The role of machine learning in clinical research: transforming the future of evidence generation
Correction to: The role of machine learning in clinical research: transforming the future of evidence generation Open
View article: The role of machine learning in clinical research: transforming the future of evidence generation
The role of machine learning in clinical research: transforming the future of evidence generation Open
View article: Correlation Between Early Endpoints and Overall Survival in Non-Small-Cell Lung Cancer: A Trial-Level Meta-Analysis
Correlation Between Early Endpoints and Overall Survival in Non-Small-Cell Lung Cancer: A Trial-Level Meta-Analysis Open
Early endpoints, such as progression-free survival (PFS), are increasingly used as surrogates for overall survival (OS) to accelerate approval of novel oncology agents. Compiling trial-level data from randomized controlled trials (RCTs) co…
View article: 663 Correlation between early endpoints and overall survival in non-small-cell lung cancer: a trial-level meta-analysis
663 Correlation between early endpoints and overall survival in non-small-cell lung cancer: a trial-level meta-analysis Open
Background In clinical trials that assess novel therapeutic agents in patients with non-small-cell lung cancer (NSCLC), early endpoints (e.g. progression-free survival [PFS] and objective response rate) are often evaluated as indicators of…
View article: Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer’s disease models
Extracellular vesicle-associated Aβ mediates trans-neuronal bioenergetic and Ca2+-handling deficits in Alzheimer’s disease models Open
View article: Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2
Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2 Open
View article: Corrigendum to “Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity”, [Exp. Neurol. 273 (2015), 151–160]
Corrigendum to “Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity”, [Exp. Neurol. 273 (2015), 151–160] Open
View article: Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons
Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons Open
View article: Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity
Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity Open