Emrah Gecili
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View article: The prevalence and impact of gluten‐free food insecurity in pediatric celiac disease
The prevalence and impact of gluten‐free food insecurity in pediatric celiac disease Open
Objectives Celiac disease (CeD) requires lifelong adherence to a gluten‐free (GF) diet (GFD), though GF foods are more expensive. This study aimed to: (1) evaluate concordance between GF and general food insecurity (FI) among households wi…
View article: Hypercubes to identify geomarkers of rapid cystic fibrosis lung disease progression
Hypercubes to identify geomarkers of rapid cystic fibrosis lung disease progression Open
The proposed method is a useful approach for selecting a small set of truly relevant demographic, clinical, and place-based predictors of rapid lung function decline while accounting for the complex correlations inherent in longitudinal lu…
View article: Heterogeneous Effect of Automated Alerts on Mortality
Heterogeneous Effect of Automated Alerts on Mortality Open
We analyzed data from 13,483 hospitalized patients with acute kidney injury (AKI) from three randomized controlled trials to assess the heterogeneous effects of automated electronic alerts on 14-day mortality. We modeled and predicted indi…
View article: Unveiling the Impact of Social and Environmental Determinants of Health on Lung Function Decline in Cystic Fibrosis through Data Integration using the US Registry
Unveiling the Impact of Social and Environmental Determinants of Health on Lung Function Decline in Cystic Fibrosis through Data Integration using the US Registry Open
Integrating diverse data sources offers a comprehensive view of patient health and holds potential for improving clinical decision-making. In Cystic Fibrosis (CF), which is a genetic disorder primarily affecting the lungs, biomarkers that …
View article: A Joint Model for (Un)Bounded Longitudinal Markers, Competing Risks, and Recurrent Events Using Patient Registry Data
A Joint Model for (Un)Bounded Longitudinal Markers, Competing Risks, and Recurrent Events Using Patient Registry Data Open
Joint models for longitudinal and survival data have become a popular framework for studying the association between repeatedly measured biomarkers and clinical events. Nevertheless, addressing complex survival data structures, especially …
View article: Characterizing heterogeneity in Alzheimer’s disease progression: a semiparametric model
Characterizing heterogeneity in Alzheimer’s disease progression: a semiparametric model Open
The progression of Alzheimer's disease (AD), a leading cause of dementia worldwide, is known for its variability and complexity, challenging the conventional methods of monitoring and predicting disease trajectories. This study introduces …
View article: Acute Exposure to Ambient Particulate Matter and Pulmonary Exacerbations: A Case-Crossover Study
Acute Exposure to Ambient Particulate Matter and Pulmonary Exacerbations: A Case-Crossover Study Open
View article: Machine Learning Approaches for Predicting Progression to Alzheimer’s Disease in Patients with Mild Cognitive Impairment
Machine Learning Approaches for Predicting Progression to Alzheimer’s Disease in Patients with Mild Cognitive Impairment Open
Purpose Alzheimer's disease (AD), a neurodegenerative disorder, is a condition that impairs cognition, memory, and behavior. Mild cognitive impairment (MCI), a transitional stage before AD, urgently needs the development of prediction mode…
View article: Spike and Slab Regression for Nonstationary Gaussian Linear Mixed Effects Modeling of Rapid Disease Progression
Spike and Slab Regression for Nonstationary Gaussian Linear Mixed Effects Modeling of Rapid Disease Progression Open
Select measures of social and environmental determinants of health (referred to as “geomarkers”), predict rapid lung function decline in cystic fibrosis (CF), defined as a prolonged decline relative to patient and/or center‐level norms. Th…
View article: Secular and modulator-specific drifts in the predictive performance of a rapid lung function decline algorithm: a cystic fibrosis patient registry study
Secular and modulator-specific drifts in the predictive performance of a rapid lung function decline algorithm: a cystic fibrosis patient registry study Open
View article: A joint model for (un)bounded longitudinal markers, competing risks, and recurrent events using patient registry data
A joint model for (un)bounded longitudinal markers, competing risks, and recurrent events using patient registry data Open
Joint models for longitudinal and survival data have become a popular framework for studying the association between repeatedly measured biomarkers and clinical events. Nevertheless, addressing complex survival data structures, especially …
View article: Predicting lung function decline in cystic fibrosis: the impact of initiating ivacaftor therapy
Predicting lung function decline in cystic fibrosis: the impact of initiating ivacaftor therapy Open
Background Modulator therapies that seek to correct the underlying defect in cystic fibrosis (CF) have revolutionized the clinical landscape. Given the heterogeneous nature of lung disease progression in the post-modulator era, there is a …
View article: Evaluating precision medicine tools in cystic fibrosis for racial and ethnic fairness
Evaluating precision medicine tools in cystic fibrosis for racial and ethnic fairness Open
Introduction: Patients with cystic fibrosis (CF) experience frequent episodes of acute decline in lung function called pulmonary exacerbations (PEx). An existing clinical and place-based precision medicine algorithm that accurately predict…
View article: Social-environmental phenotypes of rapid cystic fibrosis lung disease progression in adolescents and young adults living in the United States
Social-environmental phenotypes of rapid cystic fibrosis lung disease progression in adolescents and young adults living in the United States Open
View article: 618 Environmental exposures and spatiotemporal effects that characterize rapid lung function decline in a Midwest U.S. cystic fibrosis cohort
618 Environmental exposures and spatiotemporal effects that characterize rapid lung function decline in a Midwest U.S. cystic fibrosis cohort Open
View article: 622 Hypercubes to identify key environmental exposures predictive of rapid cystic fibrosis lung disease progression
622 Hypercubes to identify key environmental exposures predictive of rapid cystic fibrosis lung disease progression Open
View article: Lung function and secondhand smoke exposure among children with cystic fibrosis: A Bayesian meta-analysis
Lung function and secondhand smoke exposure among children with cystic fibrosis: A Bayesian meta-analysis Open
View article: Lung Function Decline in Cystic Fibrosis: Impact of Data Availability and Modeling Strategies on Clinical Interpretations
Lung Function Decline in Cystic Fibrosis: Impact of Data Availability and Modeling Strategies on Clinical Interpretations Open
Rationale: Studies estimating the rate of lung function decline in cystic fibrosis have been inconsistent regarding the methods used. How the methodology used impacts the validity of the results and comparability between studies is …
View article: 115. Automated Identification of Transgender and Gender Non-conforming patients from Electronic Health Record Data
115. Automated Identification of Transgender and Gender Non-conforming patients from Electronic Health Record Data Open
View article: Built environment factors predictive of early rapid lung function decline in cystic fibrosis
Built environment factors predictive of early rapid lung function decline in cystic fibrosis Open
Background The extent to which environmental exposures and community characteristics of the built environment collectively predict rapid lung function decline, during adolescence and early adulthood in cystic fibrosis (CF), has not been ex…
View article: Predicting Individualized Lung Disease Progression in Treatment-Naive Patients With Lymphangioleiomyomatosis
Predicting Individualized Lung Disease Progression in Treatment-Naive Patients With Lymphangioleiomyomatosis Open
View article: Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection
Tissue-localized immune responses in people with cystic fibrosis and respiratory nontuberculous mycobacteria infection Open
Nontuberculous mycobacteria (NTM) are an increasingly common cause of respiratory infection in people with cystic fibrosis (PwCF). Relative to those with no history of NTM infection (CF-NTMNEG), PwCF and a history of NTM infection (CF-NTMP…
View article: Bayesian regularization for a nonstationary Gaussian linear mixed effects model
Bayesian regularization for a nonstationary Gaussian linear mixed effects model Open
In omics experiments, estimation and variable selection can involve thousands of proteins/genes observed from a relatively small number of subjects. Many regression regularization procedures have been developed for estimation and variable …
View article: Sweat metabolomics before and after intravenous antibiotics for pulmonary exacerbation in people with cystic fibrosis
Sweat metabolomics before and after intravenous antibiotics for pulmonary exacerbation in people with cystic fibrosis Open
View article: 57: Secular drift in predictive accuracy of pulmonary exacerbations: A registry study
57: Secular drift in predictive accuracy of pulmonary exacerbations: A registry study Open
View article: 173: Separating wheat from chaff: Hypercubes to identify proteins predictive of rapid cystic fibrosis lung disease progression
173: Separating wheat from chaff: Hypercubes to identify proteins predictive of rapid cystic fibrosis lung disease progression Open
View article: 567: Optimization of methods of interrogating large proteomic data sets for disease progression prediction in CF
567: Optimization of methods of interrogating large proteomic data sets for disease progression prediction in CF Open
View article: 167: Sweat metabolomics profiling of cystic fibrosis pulmonary exacerbations
167: Sweat metabolomics profiling of cystic fibrosis pulmonary exacerbations Open
View article: 43: Monitoring and phenotyping rapid cystic fibrosis disease progression using community characteristics and environmental exposures
43: Monitoring and phenotyping rapid cystic fibrosis disease progression using community characteristics and environmental exposures Open
View article: 578: Serum biomarkers identified by proteomics and measured by commercially available assays associated with lung function during clinically stable states
578: Serum biomarkers identified by proteomics and measured by commercially available assays associated with lung function during clinically stable states Open