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View article: TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition
TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition Open
Graves' ophthalmopathy (GO) is an autoimmune disorder marked by orbital inflammation and tissue remodeling, leading to irreversible disfigurement and vision loss. The current first‐line glucocorticoid therapy remains palliative, underscori…
View article: Large-scale survey, animal models, and computational modeling identify histological neurodegenerative biomarkers for traumatic optic neuropathy
Large-scale survey, animal models, and computational modeling identify histological neurodegenerative biomarkers for traumatic optic neuropathy Open
BACKGROUNDTraumatic optic neuropathy (TON) is a leading cause of blindness following closed traumatic brain injury, with no effective treatments available. Previous interventional clinical trials were complicated by its low prevalence, var…
View article: TSHR-targeting nucleic acid aptamer treats Graves’ ophthalmopathy via novel allosteric inhibition
TSHR-targeting nucleic acid aptamer treats Graves’ ophthalmopathy via novel allosteric inhibition Open
Abnormal thyrotropin receptor (TSHR) signaling drives a spectrum of diseases affecting hundreds of millions globally, including Graves’ disease (GD), Graves’ ophthalmopathy (GO), hyperthyroidism, and thyroid cancers. Therefore, TSHR is con…
View article: CircCAMSAP1 Suppresses Uveal Melanoma Progression via miR-1182 Sponging and NONO Regulation
CircCAMSAP1 Suppresses Uveal Melanoma Progression via miR-1182 Sponging and NONO Regulation Open
Uveal melanoma (UM) is an extremely aggressive tumor with an unfavorable prognosis and few therapeutic options. Understanding the critical molecular regulators in UM is essential to improving treatment. Circular RNAs (circRNAs) have recent…
View article: Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers
Delayed Surgical Reversal of Optic Nerve Compression Leads to Exponential Degeneration of Optic Nerve Fibers and Selective Sparing of the Small Fibers Open
Persistent substantial compression on the optic nerve leads to exponential degeneration of the optic nerve, initially affecting larger optic nerve fibers. Early intervention aimed at relieving the compression on the optic nerve may offer p…
View article: Management of chronic dacryocystitis cases after failed external dacryocystorhinostomy using endoscopic technique with a novel lacrimal ostium stent
Management of chronic dacryocystitis cases after failed external dacryocystorhinostomy using endoscopic technique with a novel lacrimal ostium stent Open
AIM: To demonstrate the outcomes of endoscopic endonasal dacryocystorhinostomy (En-DCR) with an novel lacrimal ostium stent (LOS) which was performed in patients with recurrent epiphora after failed external dacryocystorhinostomy (Ex-DCR) …
View article: Endoscopic transnasal drainage for orbital implantation cyst after orbital wall reconstruction
Endoscopic transnasal drainage for orbital implantation cyst after orbital wall reconstruction Open
An implantation cyst after orbital wall reconstruction may present as a late complication, which can cause local pain, proptosis, diplopia, and vision impairment. Previous surgical strategies prefer transconjunctival or subtarsal approach …
View article: Endoscopic transnasal canaliculorhinostomy for refractory common canalicular obstruction with an unidentifiable lacrimal sac
Endoscopic transnasal canaliculorhinostomy for refractory common canalicular obstruction with an unidentifiable lacrimal sac Open
Although being surgically challenging, ETC has comparable findings to its external approach counterpart or conjunctivodacryocystorhinostomy (CDCR) with Jones tube. And it may prove to be a novel alternate surgical technique for patients wi…
View article: Navigation-Guided Endoscopy Combined with Deep Lateral Orbitotomy for Removal of Small Tumors at the Lateral Orbital Apex
Navigation-Guided Endoscopy Combined with Deep Lateral Orbitotomy for Removal of Small Tumors at the Lateral Orbital Apex Open
Purpose . To evaluate the efficacy, feasibility, and safety of the navigation-guided endoscopy combined with deep lateral orbitotomy for removal of small tumors at the lateral orbital apex. Design . A retrospective, noncomparative case ser…
View article: Rapid development of reaching/grasping and intersensory recognition in a previously blind Tibetan girl
Rapid development of reaching/grasping and intersensory recognition in a previously blind Tibetan girl Open
On a charity mission we discovered a 44 month-old Tibetan girl who was blind due to dense bilateral congenital cataracts. We report here the results of video-recorded experiments on the child immediately after post cataract surgery eye pat…