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View article: The Autophagy Inhibitor Bafilomycin Inhibits Antibody-Dependent Natural Killer Cell-Mediated Killing of Breast Carcinoma Cells
The Autophagy Inhibitor Bafilomycin Inhibits Antibody-Dependent Natural Killer Cell-Mediated Killing of Breast Carcinoma Cells Open
The resistance of breast cancer cells to therapeutic antibodies such as anti-HER2 trastuzumab can be overcome by engaging natural killer (NK) cells for killing antibody-binding tumor cells via antibody-dependent cellular cytotoxicity (ADCC…
View article: Loss of MER Tyrosine Kinase Attenuates Adipocyte Hypertrophy and Leads to Enhanced Thermogenesis in Mice Exposed to High-Fat Diet
Loss of MER Tyrosine Kinase Attenuates Adipocyte Hypertrophy and Leads to Enhanced Thermogenesis in Mice Exposed to High-Fat Diet Open
Obesity is characterized by low-grade inflammation that originates predominantly from the expanding visceral adipose tissue, in which adipocytes respond to lipid overload with hypertrophy, and consequently die by apoptosis. Recruited adipo…
View article: Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance
Smoothelin-like protein 1 promotes insulin sensitivity and modulates the contractile properties of endometrial epithelial cells with insulin resistance Open
Introduction The incidence of infertility is significantly higher in women with diseases linked to impaired glucose homeostasis, such as insulin resistance. Defective glucose metabolism interferes with fertilization; however, the molecular…
View article: Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition
Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition Open
Breast cancer patients are characterized by the oncobiotic transformation of multiple microbiome communities, including the gut microbiome. Oncobiotic transformation of the gut microbiome impairs the production of antineoplastic bacterial …
View article: KDM4-dependent DNA breaks at active promoters facilitate +1 nucleosome eviction
KDM4-dependent DNA breaks at active promoters facilitate +1 nucleosome eviction Open
When the effect of various posttranslational histone tail modifications (PTMs) on nucleosome stability was compared in an in situ assay involving agarose-embedded nuclei, the promoter proximal H3K4me3, H3K27ac and H4K8ac positive nucleosom…
View article: Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7
Migration of Myogenic Cells Is Highly Influenced by Cytoskeletal Septin7 Open
Septin7 as a unique member of the GTP binding protein family, is widely expressed in the eukaryotic cells and considered to be essential in the formation of hetero-oligomeric septin complexes. As a cytoskeletal component, Septin7 is involv…
View article: Adenosine A2A Receptor Activation Regulates Niemann–Pick C1 Expression and Localization in Macrophages
Adenosine A2A Receptor Activation Regulates Niemann–Pick C1 Expression and Localization in Macrophages Open
Adenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory …
View article: Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling
Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling Open
Adenosine A2A receptor (A2AR)-dependent signaling in macrophages plays a key role in the regulation of inflammation. However, the processes regulating A2AR targeting to the cell surface and degradation in m…
View article: The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells
The voltage-gated proton channel hHv1 is functionally expressed in human chorion-derived mesenchymal stem cells Open
The voltage-gated proton channel Hv1 is widely expressed, among others, in immune and cancer cells, it provides an efficient cytosolic H + extrusion mechanism and regulates vital functions such as oxidative burst, migration and proliferati…
View article: Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae
Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae Open
Molecular combing and gel electrophoretic studies revealed endogenous nicks with free 3'OH ends at ∼100 kb intervals in the genomic DNA (gDNA) of unperturbed and G1-synchronized Saccharomyces cerevisiae cells. Analysis of the distribution …
View article: A <sub>2A</sub> adenosine receptors control pancreatic dysfunction in high‐fat‐diet‐induced obesity
A <sub>2A</sub> adenosine receptors control pancreatic dysfunction in high‐fat‐diet‐induced obesity Open
Adenosine, a key extracellular signaling mediator, regulates several aspects of metabolism by activating 4 G‐protein‐coupled receptors, the A 1 , A 2A , A 2B , and A 3 adenosine receptors (ARs). The role of A 2A ARs in regulating high‐fat‐…
View article: PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines Open
Hyaluronan (HA) is the major glycosaminoglycan component of the extracellular matrix in either normal or malignant tissues and it may affect proliferation, motility and differentiation of various cell types. Three isoforms of plasma membra…