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View article: Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition Open
Tumor evolution is one of the major mechanisms responsible for acquiring therapy-resistant and more aggressive cancer clones. Whether the tumor microenvironment through immune-mediated mechanisms might promote the development of more aggre…
View article: Maturational competence of equine oocytes is associated with alterations in their ‘cumulome’
Maturational competence of equine oocytes is associated with alterations in their ‘cumulome’ Open
Assisted reproductive technologies are an emerging field in equine reproduction, with species-dependent peculiarities, such as the low success rate of conventional IVF. Here, the ‘cumulome’ was related to the developmental capacity of its …
View article: PSXI-16 Using a multi-omics approach to decipher trans-10 shift biomarkers in ruminants
PSXI-16 Using a multi-omics approach to decipher trans-10 shift biomarkers in ruminants Open
The trans-10 shift is a recognized deviation from the normal ruminal biohydrogenation (BH) pathways of the dietary polyunsaturated fatty acids (FA) in the rumen. This phenomenon leads to the formation of the harmful t10-18:1, which is detr…
View article: Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP-inhibition
Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP-inhibition Open
Tumor evolution is one of the major mechanisms responsible for acquiring therapy-resistant and more aggressive cancer clones. Whether the tumor microenvironment through immune-mediated mechanisms might promote the development of more aggre…
View article: Sex‐specific metabolomics‐derived blood biomarkers of Alzheimer’s disease.
Sex‐specific metabolomics‐derived blood biomarkers of Alzheimer’s disease. Open
Background Readily accessible diagnostic tools are crucial for early detection of Alzheimer’s disease (AD). Here, we sought to identify peripheral metabolism biomarkers predicting the presence of AD pathology. Method Untargeted liquid chro…
View article: Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target
Multiomic ALS signatures highlight sex differences and molecular subclusters and identify the MAPK pathway as therapeutic target Open
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and lacks effective disease-modifying treatments. Here, we performed a multiomic analysis of the prefrontal cortex of 51 patients with sporadic ALS and 50 control …
View article: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization Open
Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis. Here w…
View article: A Metabolome Analysis and the Immunity of Phlomis purpurea against Phytophthora cinnamomi
A Metabolome Analysis and the Immunity of Phlomis purpurea against Phytophthora cinnamomi Open
Phlomis purpurea grows spontaneously in the southern Iberian Peninsula, namely in cork oak (Quercus suber) forests. In a previous transcriptome analysis, we reported on its immunity against Phytophthora cinnamomi. However, little is known …
View article: Sex-specific metabolomics-derived blood biomarkers of Alzheimer’s disease
Sex-specific metabolomics-derived blood biomarkers of Alzheimer’s disease Open
Readily accessible diagnostic tools are crucial for early detection of Alzheimer’s disease (AD). Here, we sought to identify peripheral metabolism biomarkers of cerebral AD pathology. Untargeted liquid chromatography-mass spectrometry was …
View article: Metabolome analysis and immunity of Phlomis purpurea against Phytophthora cinnamomi
Metabolome analysis and immunity of Phlomis purpurea against Phytophthora cinnamomi Open
Abstract Phlomis purpurea is spontaneous in the southern Iberian Peninsula namely in cork oak (Quercus suber) forests. In a previous transcriptome analysis, we reported on its immunity against Phytophthora cinnamomi. However, little is kno…
View article: Metabolome analysis and immunity of Phlomis purpurea against Phytophthora cinnamomi
Metabolome analysis and immunity of Phlomis purpurea against Phytophthora cinnamomi Open
Abstract Phlomis purpurea is spontaneous in the southern Iberian Peninsula namely in cork oak (Quercus suber) forests. In a previous transcriptome analysis, we reported on its immunity against Phytophthora cinnamomi. However, little is kno…
View article: Data from Transcriptome Profile of Human Colorectal Adenomas
Data from Transcriptome Profile of Human Colorectal Adenomas Open
Colorectal cancers are believed to arise predominantly from adenomas. Although these precancerous lesions have been subjected to extensive clinical, pathologic, and molecular analyses, little is currently known about the global gene expres…
View article: Supplementary Data from Transcriptome Profile of Human Colorectal Adenomas
Supplementary Data from Transcriptome Profile of Human Colorectal Adenomas Open
Supplementary Data from Transcriptome Profile of Human Colorectal Adenomas
View article: Data from Transcriptome Profile of Human Colorectal Adenomas
Data from Transcriptome Profile of Human Colorectal Adenomas Open
Colorectal cancers are believed to arise predominantly from adenomas. Although these precancerous lesions have been subjected to extensive clinical, pathologic, and molecular analyses, little is currently known about the global gene expres…
View article: Supplementary Data from Transcriptome Profile of Human Colorectal Adenomas
Supplementary Data from Transcriptome Profile of Human Colorectal Adenomas Open
Supplementary Data from Transcriptome Profile of Human Colorectal Adenomas
View article: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization Open
To identify the factors that drive the metabolic switch induced by CTNS deficiency, we conducted metabolomics-based profiling of Ctns KO mouse proximal tubule cells ( mPTCs) and wild type controls. Sample preparation: Cell pellets (~5×105 …
View article: Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization Open
Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis. Here w…
View article: Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading
Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading Open
We have recently identified point mutation V336Y in mitoribosomal protein Mrps5 (uS5m) as a mitoribosomal ram (ribosomal ambiguity) mutation conferring error-prone mitochondrial protein synthesis. In vivo in transgenic knock-in animals, ho…
View article: Metabolomic Profiling and Toxicokinetics Modeling to Assess the Effects of the Pharmaceutical Diclofenac in the Aquatic Invertebrate <i>Hyalella azteca</i>
Metabolomic Profiling and Toxicokinetics Modeling to Assess the Effects of the Pharmaceutical Diclofenac in the Aquatic Invertebrate <i>Hyalella azteca</i> Open
The exposure of ecologically critical invertebrate species to biologically active pharmaceuticals poses a serious risk to the aquatic ecosystem. Yet, the fate and toxic effects of pharmaceuticals on these nontarget aquatic invertebrates an…
View article: The metabolome and lipidome of colorectal adenomas and cancers
The metabolome and lipidome of colorectal adenomas and cancers Open
Introduction In-depth knowledge of metabolic dysregulations in colorectal cancer (CRC) (and other cancers as well) is essential for developing treatments that specifically kill neoplastic cells. It may also allow us to pinpoint metabolites…
View article: Mitochondrial Mistranslation in Brain Provokes a Metabolic Response Which Mitigates the Age-Associated Decline in Mitochondrial Gene Expression
Mitochondrial Mistranslation in Brain Provokes a Metabolic Response Which Mitigates the Age-Associated Decline in Mitochondrial Gene Expression Open
Mitochondrial misreading, conferred by mutation V338Y in mitoribosomal protein Mrps5, in-vivo is associated with a subtle neurological phenotype. Brain mitochondria of homozygous knock-in mutant Mrps5V338Y/V338Y mice show decreased oxygen …
View article: Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation
Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation Open
We have recently reported on an experimental model of mitochondrial mistranslation conferred by amino acid exchange V338Y in mitochondrial ribosomal protein MrpS5. Here we used a combination of RNA-seq and metabolic profiling of homozygous…
View article: Regional Differences in Penetration of the Protein Stabilizer Trimethoprim (TMP) in the Rat Central Nervous System
Regional Differences in Penetration of the Protein Stabilizer Trimethoprim (TMP) in the Rat Central Nervous System Open
Regulating gene expression at the protein level is becoming increasingly important for answering basic questions in neurobiology. Several techniques using destabilizing domains (DD) on transgenes, which can be activated or deactivated by s…