John R. Endres
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An Evaluation of Genotoxicity and 90‐Day Repeated‐Dose Oral Toxicity in Rats of <span>DracoBelle</span> Nu sd Open
The safety of a powdered aqueous extract of Dracocephalum moldavica spray‐dried with maltodextrin (DracoBelle Nu sd) was examined through a battery of in vitro and in vivo toxicological studies including a bacterial reverse mutation test, …
An evaluation of genotoxicity and 90-day repeated-dose toxicity in rats of a <i>Dracocephalum moldavica</i> powdered extract Open
The safety of a powdered extract of Dracocephalum moldavica (Dracobelle™ Nu sd) was examined through a battery of in vitro and in vivo toxicological studies including a bacterial reverse mutation test, an in vivo mammalian micronucleus ass…
A Comprehensive Toxicological Safety Evaluation of <i>Anaerostipes caccae</i> Open
Anaerostipes caccae CLB101 (CLB101) is an obligate, anaerobic bacteria that was isolated from the stool of a healthy infant. Due to its ability to produce butyrate and its potential promotion of microbiome health through multiple homeostat…
View article: Leg and hip muscles show muscle‐specific effects of ageing and sport on muscle volume and fat fraction in male Masters athletes
Leg and hip muscles show muscle‐specific effects of ageing and sport on muscle volume and fat fraction in male Masters athletes Open
Age‐related deterioration in muscle volume, intramuscular fat content and muscle function can be modulated by physical activity. We explored whether Masters athletes, as examples of highly physically active people into old age, could preve…
90‐day oral toxicity study in rats of a protein‐rich powder derived from <i>Xanthobacter</i> sp. SoF1 Open
Xanthobacter sp. SoF1 (SoF1) is an autotrophic hydrogen‐oxidizing bacteria that produces protein‐rich biomass and has potential to be an alternative protein source that is more environmentally sustainable than animal and plant derived prot…
A 90‐day toxicity study of tripeptide, arginine‐alanine‐lysine Open
There is a growing global interest in using peptides in the health industry for pharmaceuticals, cosmetics, and natural food products. Peptides contain two or more linked amino acids, whereas more than 50 amino acids are classified as poly…
Toxicological evaluation of protein powder derived from <span><i>Cupriavidus necator</i></span> Open
Microorganisms have the potential to produce nutrient‐rich products that can be consumed as food or feed. The protein‐rich powder derived from heat treatment of the whole‐cell biomass of polyhydroxybutyrate‐deficient Cupriavidus necator , …
A toxicological evaluation of lithium orotate Open
Lithium orotate, the salt of lithium and orotic acid, has been marketed for decades as a supplemental source of lithium with few recorded adverse events. Nonetheless, there have been some concerns in the scientific literature regarding oro…
A Toxicological Evaluation of Germanium Sesquioxide (Organic Germanium) Open
A battery of OECD- and GLP-compliant toxicological studies was performed to assess the safety of a highly purified germanium sesquioxide, an organic form of the naturally occurring, nonessential trace element germanium. Germanium dioxide a…
A Toxicological Evaluation of Methylliberine (Dynamine®) Open
Methylliberine (CAS 51168-26-4), a methoxiuric acid, is a caffeine metabolite present at low levels in various Coffea plants; however, very little has been published regarding this compound and we could find no toxicological data in the pu…
A Toxicological Evaluation of Mango Leaf Extract (<i>Mangifera indica</i>) Containing 60% Mangiferin Open
A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract ( Mangifera indica ) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While e…
Toxicological Evaluation of a Mixture of<i> Astragalus membranaceus</i> and<i> Panax notoginseng</i> Root Extracts (InnoSlim®) Open
Astragalus spp. and Panax spp. have a long history of traditional human use. A blend, InnoSlim®, of highly purified and fractionated root extracts from Astragalus membranaceus and Panax notoginseng has now been developed for human consumpt…
An Assessment of the Genotoxicity and Subchronic Toxicity of a Supercritical Fluid Extract of the Aerial Parts of Hemp Open
A battery of toxicological studies was conducted on a supercritical CO 2 extract of the aerial parts of the Cannabis sativa plant, containing approximately 25% cannabinoids. No evidence of genotoxicity was found in a bacterial reverse muta…
A Toxicological Assessment of Creatyl-<span>l</span>-Leucine Open
A battery of toxicological studies was conducted to investigate the genotoxicity and repeated-dose oral toxicity of creatyl-l-leucine, a synthetic compound, in rats in accordance with internationally accepted guidelines. There was no evide…
A Toxicological Evaluation of <i>Chlamydomonas reinhardtii</i>, a Green Algae Open
There is a current worldwide interest in developing novel sustainable nonanimal nutritional sources, and one such source is the green algae Chlamydomonas reinhardtii, the only green algae that has been studied as a model organism for many …
A 28-Day Repeated Dose Toxicological Study of an Aqueous Extract of <i>Morus Alba</i> L. Open
Morus alba L. (white mulberry) leaves are one of the oldest recognized traditional Chinese medicines. More recently, M alba leaves and their constituents, particularly iminosugars (or azasugars), have garnered attention for their ability t…
A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine Open
A 90-day repeated-dose oral toxicological evaluation was conducted according to GLP and OECD guidelines on the methylurate purine alkaloid theacrine, which is found naturally in certain plants. Four groups of Hsd.Brl.Han Wistar rats (ten/s…