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View article: Preventing vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA
Preventing vision loss in a mouse model of Leber Congenital Amaurosis by engineered tRNA Open
Premature termination codons (PTCs) are associated with rare genetic disorders. Inducing targeted read-through of these ‘nonsense mutations’ presents a potential therapeutic strategy for modifying disease outcomes. We previously reported t…
View article: Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations
Intersection of epilepsy and cardiac health: Insights from electrocardiography and syndromic associations Open
Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifes…
View article: Insights Into Retinal Pathologies in Neurological Disorders: A Focus on Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease
Insights Into Retinal Pathologies in Neurological Disorders: A Focus on Parkinson's Disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, and Alzheimer's Disease Open
Neurological diseases are central nervous system (CNS) disorders affecting the whole body. Early diagnosis of the diseases is difficult due to the lack of disease‐specific tests. Adding new biomarkers external to the CNS facilitates the di…
View article: Extracellular vesicle and CRISPR gene therapy: Current applications in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease
Extracellular vesicle and CRISPR gene therapy: Current applications in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and Huntington's disease Open
Neurodegenerative diseases are characterized by progressive deterioration of the nervous system. Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD) are prominently life‐th…
View article: Attitudes toward COVID-19 vaccines during pregnancy and breastfeeding
Attitudes toward COVID-19 vaccines during pregnancy and breastfeeding Open
Background Although vaccination is one of the most effective means of controlling the spread of COVID-19, public concerns and indecision about vaccination still continue. Because pregnant and breastfeeding individuals are at high risk for …
View article: Gender‐related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model
Gender‐related variation expressions of neuroplastin TRAF6, GluA1, GABA(A) receptor, and PMCA in cortex, hippocampus, and brainstem in an experimental epilepsy model Open
Epileptic seizures are seen as a result of changing excitability balance depending on the deterioration in synaptic plasticity in the brain. Neuroplastin, and its related molecules which are known to play a role in synaptic plasticity, neu…
View article: Molecular Investigation of Viral Agents in Cattle with Respiratory System Problems
Molecular Investigation of Viral Agents in Cattle with Respiratory System Problems Open
This study was carried out to investigate viral etiology using molecular methods in cattle with respiratory system problems. The animal material of the study consisted of 200 cattle of different breeds, age and sex, which were not vaccinat…
View article: Traumatic brain injury-induced peripheral damage: The dynamics of the inflammatory and autophagy pathway from acute to chronic stages
Traumatic brain injury-induced peripheral damage: The dynamics of the inflammatory and autophagy pathway from acute to chronic stages Open
The results showed that TBI may elicit peripheral molecular responses, particularly in terms of alteration in the levels of inflammatory cytokines and autophagy markers, which were gender- and time-dependent. This suggests that TBI may hav…
View article: Effects of melatonin on the circadian functions of sleep-wake cycle, metabolism, hormonal regulation and immune activity: A recent review
Effects of melatonin on the circadian functions of sleep-wake cycle, metabolism, hormonal regulation and immune activity: A recent review Open
Rhythms following a period of approximately 24 hours are called circadian (from Latin circa diem, approximately one day) rhythms. These rhythms are observed in the activities of various vital body functions. Melatonin is considered as an i…
View article: Editorial: Ion-channels in epilepsy
Editorial: Ion-channels in epilepsy Open
EDITORIAL article Front. Neurol., 10 August 2023Sec. Epilepsy Volume 14 - 2023 | https://doi.org/10.3389/fneur.2023.1263539
View article: Evaluation of linagliptin and insulin combined therapy on unfolded protein response in type 1 diabetic mouse heart
Evaluation of linagliptin and insulin combined therapy on unfolded protein response in type 1 diabetic mouse heart Open
The aim of this study is to reveal the effects of the use of linagliptin, a DPP‐4 inhibitor due to its beneficial cardiovascular effects, on endoplasmic reticulum stress (ERS) signaling, which is involved in the pathogenesis of cardiovascu…
View article: Are medical students aware of SUDEP? A survey in Turkey
Are medical students aware of SUDEP? A survey in Turkey Open
Objective Sudden unexpected death in epilepsy (SUDEP) has been recognized as an important cause of death in patients with epilepsy. In order to inform patients with epilepsy and their relatives correctly, it is necessary to increase the aw…
View article: Tauroursodeoxycholic Acid (TUDCA) Regulates Inflammation and Hypoxia in Autonomic Tissues of Rats with Seizures
Tauroursodeoxycholic Acid (TUDCA) Regulates Inflammation and Hypoxia in Autonomic Tissues of Rats with Seizures Open
Inflammation and hypoxia have an effect on the molecular mechanism of cardiovascular and respiratory pathologies accompanying seizures. Against this, Tauroursodeoxycholic Acid (TUDCA) can regulate oxidative stress, inflammation and cellula…
View article: Immunoreactivity of Kir3.1, muscarinic receptors 2 and 3 on the brainstem, vagus nerve and heart tissue under experimental demyelination
Immunoreactivity of Kir3.1, muscarinic receptors 2 and 3 on the brainstem, vagus nerve and heart tissue under experimental demyelination Open
Wistar albino rats were randomly divided into 8 groups; duplicating 4 groups as male and female: control groups (n = 3 +3), Cuprizone groups (n = 12 +12), sham groups (n = 4 +4), and carboxy-methyl-cellulose groups (n = 3 +3). Cuprizone-fe…
View article: Immunohistochemical neuroinflammatory markers in the hippocampus of PTZ-kindled rats under conditions of rapamycin and axitinib treatment
Immunohistochemical neuroinflammatory markers in the hippocampus of PTZ-kindled rats under conditions of rapamycin and axitinib treatment Open
The aim of the study is to determine the level of HIF-1α, TNF-α, and NF-kB in the hippocampus of kindled rats treated with rapamycin and axitinib.
Materials and methods. Kindling was produced in 29 rats by administration of three-week pen…
View article: ON THE ROLE OF TUMOR NECROSIS FACTOR-ALPHA (TNF-α) AND NUCLEAR FACTOR p-NF-κB IN THE PENTYLENETETRAZOLE KINDLING PATHOGENESIS
ON THE ROLE OF TUMOR NECROSIS FACTOR-ALPHA (TNF-α) AND NUCLEAR FACTOR p-NF-κB IN THE PENTYLENETETRAZOLE KINDLING PATHOGENESIS Open
Determining the role of endogenous factors as markers of chronic epileptic activity allows pathogenetically justifying new approaches to treating epilepsy. The aim of the work was the immunohistochemical study of the expression of the tumo…
View article: Effects of Lateral Cerebellar Nucleus Stimulation on Seizures in Rats Kindled to Different Levels of Seizure Severity with PTZ
Effects of Lateral Cerebellar Nucleus Stimulation on Seizures in Rats Kindled to Different Levels of Seizure Severity with PTZ Open
Background In recent years, the cerebellum and its nuclei have become important targets for understanding and suppressing the mechanisms of seizures. The aim of this study was to investigate the effects of electrical stimulation (ES) appli…
View article: Investigation of the Prevalence of Dirofilaria immitis in Dogs in Ardahan Region
Investigation of the Prevalence of Dirofilaria immitis in Dogs in Ardahan Region Open
The aim of this study was to determine the prevalence of Dirofilaria immitis (D. immitis) in dogs in the Ardahan region. The study material consisted of 100 Akbaş crossbred dogs (53 females and 47 males) between the ages of 3-7 in Ardahan …
View article: Multifunctional “Janus‐Type” Bilayer Films Combine Broad‐Range Tissue Adhesion with Guided Drug Release
Multifunctional “Janus‐Type” Bilayer Films Combine Broad‐Range Tissue Adhesion with Guided Drug Release Open
Tissue healing is a challenging process that requires the successful and simultaneous management of conflicting priorities. While promoting wound closure, a battle must be won against different external factors that may adversely affect th…
View article: Chloroquine Decreased Kir6.2 Immunoreactivity in Chronic Hypoxic Heart
Chloroquine Decreased Kir6.2 Immunoreactivity in Chronic Hypoxic Heart Open
Objective:Experimental and clinical studies indicate that cardiovascular system diseases have the highest mortality rate. One of the major factors underlying this high mortality rate is hypoxia. The inward rectifying potassium channel 6.2 …
View article: Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside
Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside Open
Background: Sepsis is a serious clinical condition characterized by damage to the immune system as a result of an uncontrolled response to infection. Septic patients show complications such as fever, cardiovascular shock, and/or systemic o…
View article: Functional Characterization of KCNMA1 mutation associated with dyskinesia, seizure, developmental delay, and cerebellar atrophy
Functional Characterization of KCNMA1 mutation associated with dyskinesia, seizure, developmental delay, and cerebellar atrophy Open
KCNMA1 located on chromosome 10q22.3, encodes the pore-forming α subunit of the “Big K+” (BK) large conductance calcium and voltage-activated K + channel. BK channels are widely distributed across tissues, including both excitable and non …
View article: Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy
Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy Open
Over the decades, various interventions have been developed and utilized to treat epilepsy. However, the majority of epileptic patients are often first prescribed anti-epileptic drugs (AED), now known as anti-seizure drugs (ASD), as the fi…