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View article: Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study
Evaluation of the Therapeutic Effects of Thymbra Spicata L. var spicata and Cyclotrichium Origanifolium in Spinal Cord Injury: An Experimental Study Open
Aim: Secondary tissue damage caused by oxidative stress and inflammation in spinal cord injury complicates treatment and highlights the need for novel therapeutic agents. This study aimed to evaluate the potential effects of Thymbra spicat…
View article: Rosmarinic Acid Alleviated Cyclophosphamide-Induced Gonadal Toxicity in Adult Male Rats
Rosmarinic Acid Alleviated Cyclophosphamide-Induced Gonadal Toxicity in Adult Male Rats Open
Background/Aim: This study aimed to investigate the potential protective effects of rosmarinic acid (RA) against cyclophosphamide (CP)-induced gonadal toxicity in male Wistar Albino rats. Specifically, the research focused on the modulatio…
View article: Investigation of the Protective Effect of Thymbra Spicata L. var Spicata and Cyclotrichium Origanifolium on Bladder in Experimental Traumatic Spinal Cord Injury
Investigation of the Protective Effect of Thymbra Spicata L. var Spicata and Cyclotrichium Origanifolium on Bladder in Experimental Traumatic Spinal Cord Injury Open
Objective: Spinal cord injuries typically result from trauma-induced fractures, dislocations, ligament injuries, and tears in the vertebral column. Among the most commonly affected organs in these injuries is the bladder. Thymbra spicata L…
View article: Investigation of PLGF, sFlt-1 Expression in Placenta Previa, Placenta Accreta and Normotensive Placentas in the 3rd Trimester of Pregnancy
Investigation of PLGF, sFlt-1 Expression in Placenta Previa, Placenta Accreta and Normotensive Placentas in the 3rd Trimester of Pregnancy Open
Background: We aimed to immunohistochemically examine the expression level of Placental growth factor (PLGF) and Soluble FMS-like tyrosine kinase-1 (sFlt-1) proteins in normotensive, Placenta accreta (PA) and Placenta previa (PP). Material…
View article: Immunohistochemical Analysis of Vimentin and Zonula Occludens-1 in Placentas of Patients with PPROM
Immunohistochemical Analysis of Vimentin and Zonula Occludens-1 in Placentas of Patients with PPROM Open
Background: We aimed to investigate the immunohistochemical staining of vimentin and zonula occludens-1 (ZO-1) expression in the placentas of pregnant women with preterm premature rupture of membranes (PPROM). Methods: Placentas of 25 heal…
View article: Expression of sirtuins 1 in placenta, umbilical cord, and maternal serum of patients diagnosed with placenta accreta spectrum
Expression of sirtuins 1 in placenta, umbilical cord, and maternal serum of patients diagnosed with placenta accreta spectrum Open
SIRT1 may play an important role in the pathogenesis of the PAS.
View article: Effect of hesperidin on deltamethrin toxicity in rat periodontal membrane
Effect of hesperidin on deltamethrin toxicity in rat periodontal membrane Open
Aim: Deltamethrin (DM), a hydrophobic and lipophilic substance used for insect control, easily accumulates in the body, increasing ROS production and causing mucosal inflammation and damage. The aim of this study was to explore the prophyl…
View article: EGFR expression in COVID19 placentas
EGFR expression in COVID19 placentas Open
Introduction: Coronavirus disease 2019 (COVID-19) pandemic is a global health problem that has claimed many lives worldwide. The disease is affecting almost all populations, but it poses a particular risk for groups such as the elderly and…
View article: Effects of Meningic Extract on Testicular Torsion/Detorsion
Effects of Meningic Extract on Testicular Torsion/Detorsion Open
Introduction: Testicular torsion leads to impaired blood supply to the testicles and ischaemia. The incidence is higher especially in newborns and adolescents. As in the treatment of many diseases, various plant combinations are used to pr…
View article: Histopatological Changes in Plasenta Previa, Plasenta Acreata and Normotensive Plasentas in the 3rd Trimestry of Pregnancy
Histopatological Changes in Plasenta Previa, Plasenta Acreata and Normotensive Plasentas in the 3rd Trimestry of Pregnancy Open
Introduction: One of the consequences of improper placentation is placenta previa, a condition in which the placenta is located on or near the internal cervical os. This condition is the major cause of bleeding in the last trimester of pre…
View article: Investigation of the Protective Effect of Terebinth (Pistacia terebinthus L.) against Ovarian Ischemia-Reperfusion Damage in Rat
Investigation of the Protective Effect of Terebinth (Pistacia terebinthus L.) against Ovarian Ischemia-Reperfusion Damage in Rat Open
The aim of this study is to investigate the therapeutic and protective effects of Pistacia terebinthus L. (terebinth) oil treatment on experimental ovarian ischemia and reperfusion injury in rats. In the study, 32 Sprague-Dawley female rat…
View article: Investigation of Bax and Phospho-Tau Protein Expression in Preeclampsia Placenta
Investigation of Bax and Phospho-Tau Protein Expression in Preeclampsia Placenta Open
Background: Preeclampsia is a pregnancy complication with a high morbidity and mortality rate.BAX is a proapoptotic protein and in recent years, 14-3-3 tau proteins are considered as key regulators of many processes, such as apoptosis. In …
View article: Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study
Severe preeclampsia complicated by HELLP syndrome alters the structure of Hofbauer and syncytiotrophoblast cells: ultrastructural and immunohistochemical study Open
Background Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is generally considered to be a variant or complication of preeclampsia. It is a life-threatening obstetric complication. Objectives To evaluate the immunohi…
View article: Effect of Aloe Vera On Mmp-1 And Timp-1 Expression on Diabetic Wound Healing
Effect of Aloe Vera On Mmp-1 And Timp-1 Expression on Diabetic Wound Healing Open
Aim: The aim of this study is to investigate the healing aspect of aloe vera in diabetes mellitus, which inhibits wound healing. Methods: Diabetes model was created with streptozotocin. At the end of the 14-day experiment, blood glucose wa…
View article: Investigation of Beclin 1 and TNF-α expressions in preeclampsia placentas: Immunohistochemical study
Investigation of Beclin 1 and TNF-α expressions in preeclampsia placentas: Immunohistochemical study Open
Background: Preeclampsia is a pregnancy complication Aim of this study was to investigate expression of Beclin1 and tumor necrosis factor (TNF)-α in normotensive and preeclamptic placentas of pregnant women patients. Methods: Twenty normot…
View article: The Investigation of Caspase-3 and Tumor Necrosis Factor-Alpha Expression in Placentas of Patients with Preterm Premature Rupture of Membranes
The Investigation of Caspase-3 and Tumor Necrosis Factor-Alpha Expression in Placentas of Patients with Preterm Premature Rupture of Membranes Open
Background: Caspase-3 is involved in the execution of apoptosis and is widely used as an apoptotic marker. Tumor necrosis factor-α (TNF-α) released from activated macrophages has various functions such as modulation of cell growth and diff…
View article: Effects of Quince Gel and Hesperidin Mixture on Experimental Endometriosis
Effects of Quince Gel and Hesperidin Mixture on Experimental Endometriosis Open
Objectives: Endometriosis (EM) is the presence of endometrial tissue outside the uterus. This study aimed to examine the effects of quince gel and hesperidin treatment on uterine tissue in an experimental endometriosis model. Materials and…
View article: Evaluation of the Effect of Resveratrol on Hippocampus in Experimental Traumatic Brain Injury
Evaluation of the Effect of Resveratrol on Hippocampus in Experimental Traumatic Brain Injury Open
Aim: Many antioxidant compounds have been tried to prevent traumatic brain injury (TBI). In this study, we aimed to demonstrate the therapeutic effect of Resveratrol in the hippocampus in TBI by histopathologic and immunologic evaluation. …
View article: Investigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM
Investigation of the Sox-9 and Caspase-6 Immune Activity in Placentas of Pregnant Women with GDM Open
Aim: In this study, we investigated the immunohistochemical staining of Sox-9 and Caspase-6 expression in placentas of pregnant woman with gestational diabetes mellitus (GDM). Material and Methods: Placentas of 20 healthy and 20 women with…
View article: ADM and SFLT-1 Expression in Placentas with Gestational Diabetes Mellitus
ADM and SFLT-1 Expression in Placentas with Gestational Diabetes Mellitus Open
Aim: In this study, we aimed to examine the expression levels of Adrenomedullin (ADM) and soluble fms-like tyrosine kinase-1 (sFlt-1), two novel proteins found to be involved in vascular regulation in gestational diabetes mellitus (GDM), t…
View article: NF-ĸB expression in endometriosis induced rat uterine tissue
NF-ĸB expression in endometriosis induced rat uterine tissue Open
Objective: Our aim in this study is to examine the effects of endometriosis on uterine tissue.
Materials and methods: Two groups were formed, with eight rats in each group. Sham group was subjected only saline solution for 7 days. The end…
View article: Investigation of the Sox-9 and Cited-1 Immune Activity in Placentas of Women with Placenta Accreta
Investigation of the Sox-9 and Cited-1 Immune Activity in Placentas of Women with Placenta Accreta Open
Aim: In this study, we investigated the immune activity of the Sox-9 and Cited-1 in women with placenta accreta. Material and Methods: 20 healthy and 20 placenta accreta were processed for routine histological tissue processing. Placentals…
View article: Expression of VEGF in Fallopian tubes in Ovarian Ischemia-Reperfusion
Expression of VEGF in Fallopian tubes in Ovarian Ischemia-Reperfusion Open
Aim: Our aim was to investigate expression level of VEGF in tuba uterine in ovarian ischemia-reperfusion (I/R) by immunohistochemical techniques. Material and Methods: 30 Sprague Dawley female rats were categorized into three groups. Sham …
View article: DENEYSEL DİYABETİK RATLARDA İNSİZYONEL YARA İYİLEŞMESİNDE ALOE VERA’NIN ETKİNLİĞİNİN MMP-1 VE TIMP-1 YÖNÜNDEN İNCELENMESİ
DENEYSEL DİYABETİK RATLARDA İNSİZYONEL YARA İYİLEŞMESİNDE ALOE VERA’NIN ETKİNLİĞİNİN MMP-1 VE TIMP-1 YÖNÜNDEN İNCELENMESİ Open
Purpose: The aim of this study is to investigate the healing aspect of aloe vera in diabetes mellitus, which inhibits wound healing.Materials and methods: Diabetes model was created with streptozotocin. At the end of the 14-day experiment,…
View article: Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity
Protective effect of nebivolol on rat ovary exposed to deltamethrin toxicity Open
It was thought that deltamethrin toxicity adversely affected follicle development by inducing degeneration and apoptotic process in preantral and antra follicle cells, and nebivolol administration might reduce inflammation and slow down th…
View article: Biochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissue
Biochemical and immunohistochemical examination of the effects of ephedrine in rat ovary tissue Open
The effect of apoptosis, which occurs with the signaling that starts in the cell nucleus, caused the cessation of the stimulating effect at the nuclear level after EPH administration, and a decrease in the antioxidative effect in IR damage…
View article: Histopathological, ultrastructural, and immunohistochemical examination of changes in the placenta as a result of severe preeclampsia
Histopathological, ultrastructural, and immunohistochemical examination of changes in the placenta as a result of severe preeclampsia Open
PURPOSE: To investigate the role of hypoxia-inducible transcription factor-1 alpha (HIF-1α) and angiogenetic factor endothelin-1 (ET-1) expression in regulating hypoxia and placental development by routine histopathological methods. METHOD…
View article: Effects of daidzein on rat ovary against ischemia-reperfusion
Effects of daidzein on rat ovary against ischemia-reperfusion Open
After the I/R procedure, ovarian cells and follicles were degenerated with apoptosis and inflammation. After daidzein treatment, Bax and Bcl-2 signal were decreased. It was observed that daidzein stopped the apoptotic process.
View article: Role of SOX9 and Hif-1α expression in placentas of patients with HELLP
Role of SOX9 and Hif-1α expression in placentas of patients with HELLP Open
Hif-1α and SOX9 proteins can be used as a marker to show severity of preeclampsia and regulation of cell proliferation and angiogenesis during placental development.
View article: Effect of Cadmium Chloride Toxicity on Olfactory Mucosa
Effect of Cadmium Chloride Toxicity on Olfactory Mucosa Open
Cadmium is a highly toxic metal and affects the respiratory mucosa. The aim of the study is to show the inflammation and degenerative effect of cadmium on the olfactory mucosa. In this study, eight-week-old Wistar rats with an average weig…