Enjie Xu
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View article: Separated-incision versus T-incision for internal hemipelvectomy related to Enneking type II + III resection: comparative outcomes in a single-center retrospective cohort
Separated-incision versus T-incision for internal hemipelvectomy related to Enneking type II + III resection: comparative outcomes in a single-center retrospective cohort Open
BACKGROUND: The T-incision approach for internal hemipelvectomy necessitates extensive dissection to expose the posterior pelvic structures, leading to higher rates of wound complications. A modified separated-incision approach was develop…
View article: Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity
Activation of HTR2B Suppresses Osteosarcoma Progression through the STAT1‐NLRP3 Inflammasome Pathway and Promotes OASL1+ Macrophage Production to Enhance Antitumor Immunity Open
Osteosarcoma is a primary malignant bone tumor originating from mesenchymal tissue, and associated with poor prognosis. The 5‐hydroxytryptamine receptor 2B (HTR2B), a receptor for serotonin, is known to play a role in the progression of mu…
View article: Thrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in Osteosarcoma
Thrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in Osteosarcoma Open
Dedifferentiation of osteosarcoma cells leads to poor prognosis. We plan to identify the key molecules that are involved in cell dedifferentiation and explore how they promote the pulmonary metastasis of osteosarcoma cells. We performed a …
View article: [Corrigendum] Nucleosome‑binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2‑OS osteosarcoma cell lines
[Corrigendum] Nucleosome‑binding protein HMGN2 exhibits antitumor activity in human SaO2 and U2‑OS osteosarcoma cell lines Open
Following the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 5A on p. 1305, the same xenograft tumor image had been selected for a pair of the GFP/U2‑OS experiments, where the images fro…
View article: Low NT5DC2 expression predicts favorable prognosis and suppresses soft tissue sarcoma progression via ECM-receptor interaction pathway
Low NT5DC2 expression predicts favorable prognosis and suppresses soft tissue sarcoma progression via ECM-receptor interaction pathway Open
View article: Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index
Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index Open
Background Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to str…
View article: Design of 3D-printed prostheses for reconstruction of periacetabular bone tumors using topology optimization
Design of 3D-printed prostheses for reconstruction of periacetabular bone tumors using topology optimization Open
Background: Prostheses for the reconstruction of periacetabular bone tumors are prone to instigate stress shielding. The purpose of this study is to design 3D-printed prostheses with topology optimization (TO) for the reconstruction of per…
View article: (E)‐SIS3 suppressed osteosarcoma progression via promoting cell apoptosis, arresting cell cycle, and regulating the tumor immune microenvironment
(E)‐SIS3 suppressed osteosarcoma progression via promoting cell apoptosis, arresting cell cycle, and regulating the tumor immune microenvironment Open
Osteosarcoma is a prevalent malignant bone tumor with a poor prognosis. Mothers against decapentaplegic homolog 3 (Smad3) present as a therapeutic target in antitumor treatment, whereas its functions in the osteosarcoma have not been well …
View article: Location Detection Method of Detector in Pipeline Using VMD Algorithm and Machine Learning Classifier
Location Detection Method of Detector in Pipeline Using VMD Algorithm and Machine Learning Classifier Open
The internal detector in a pipeline needs to use the ground marker to record the elapsed time for accurate positioning. Most existing ground markers use the magnetic flux leakage testing principle to detect whether the internal detector pa…
View article: Comparing Thoracic Extensive Laminoplasty (TELP) and Laminectomy in Treating Severe Thoracic Ligamentum Flavum Ossification: A Proposed Novel Technique and Case‐Control Study
Comparing Thoracic Extensive Laminoplasty (TELP) and Laminectomy in Treating Severe Thoracic Ligamentum Flavum Ossification: A Proposed Novel Technique and Case‐Control Study Open
Objective . (1) To propose a novel technique named thoracic extensive laminoplasty (TELP) in curing severe thoracic ligamentum flavum ossification (STOLF) and (2) to compare outcomes between TELP and laminectomy in curing STOLF. Methods . …
View article: An Anti-collision Early Warning System for Mine Trucks Based on RBF Network and WIFI
An Anti-collision Early Warning System for Mine Trucks Based on RBF Network and WIFI Open
Heavy-duty trucks in open-pit mines are of huge size and blind areas, so it is difficult for drivers to see other vehicles around the blind areas. In addition, due to the dullness of transportation in mines, drivers are prone to distractio…
View article: Exome sequencing analysis identifies frequent oligogenic involvement and <i>FLNB</i> variants in adolescent idiopathic scoliosis
Exome sequencing analysis identifies frequent oligogenic involvement and <i>FLNB</i> variants in adolescent idiopathic scoliosis Open
Background Adolescent idiopathic scoliosis (AIS) is a genetically heterogeneous disease characterised by three-dimensional deformity of the spine in the absence of a congenital spinal anomaly or neurological musculoskeletal disorder. The c…
View article: Exogenous HMGN2 inhibits the migration and invasion of osteosarcoma cell lines
Exogenous HMGN2 inhibits the migration and invasion of osteosarcoma cell lines Open
Our results demonstrated that exogenous HMGN2 plays a role in inhibiting OS metastasis, which could act as a basis for new ideas for future anti-tumor therapy research.
View article: C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation
C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation Open
Numerous factors have been claimed to play important roles in colorectal cancer (CRC) tumorigenesis, including myeloid-derived suppressor cells (MDSCs) and other immune cells, cytokines, and chemokines; however, the precise mechanisms of c…
View article: Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis
Hypoxia-Inducible Factor 1A Upregulates HMGN5 by Increasing the Expression of GATA1 and Plays a Role in Osteosarcoma Metastasis Open
Osteosarcoma is one of the most common malignant tumors in children and adolescents and is characterized by early metastasis. High-mobility group N (HMGN) domains are involved in the development of several tumors. Our previous study found …
View article: Asymmetric expression of GPR126 in the convex/concave side of the spine is associated with spinal skeletal malformation in adolescent idiopathic scoliosis population
Asymmetric expression of GPR126 in the convex/concave side of the spine is associated with spinal skeletal malformation in adolescent idiopathic scoliosis population Open
View article: A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis Population
A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis Population Open
Adolescent idiopathic scoliosis (AIS) is the most common spinal deformity disease in adolescents but its etiology and pathogenesis are still unclear. The current study aims to identify the relationship between single nucleotide polymorphis…
View article: Coronal Imbalance after Selective Posterior Thoracic Fusion in Patients with Lenke 1 and 2 Adolescent Idiopathic Scoliosis
Coronal Imbalance after Selective Posterior Thoracic Fusion in Patients with Lenke 1 and 2 Adolescent Idiopathic Scoliosis Open
Coronal decompensation is a common complication in Lenke 1 or 2 AIS patients after selective thoracic fusion (STF). However, the majority who developed immediately postoperative coronal decompensation experienced improvement and the relate…
View article: MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy
MicroRNA-140-5p regulates osteosarcoma chemoresistance by targeting HMGN5 and autophagy Open
View article: Inhibition of Complement Retards Ankylosing Spondylitis Progression
Inhibition of Complement Retards Ankylosing Spondylitis Progression Open
View article: Complement component 6 deficiency increases susceptibility to dextran sulfate sodium-induced murine colitis
Complement component 6 deficiency increases susceptibility to dextran sulfate sodium-induced murine colitis Open
As a potent effector of innate immunity, the complement system has been shown to be involved in the pathogenesis of inflammatory bowel disease (IBD). However, the role of the membrane attack complex (MAC) in the development of IBD is still…
View article: miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3
miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3 Open
Osteosarcoma is the most common human primary malignant bone tumor and recurrences are common due to the development of chemoresistance. However, the underlying molecular mechanism for chemoresistance remains unclear. Recent studies demons…