Enoch Tay
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View article: Targeted Metagenomics Reveals High Diversity and Rising Macrolide Resistance in Mycoplasma pneumoniae in Australia
Targeted Metagenomics Reveals High Diversity and Rising Macrolide Resistance in Mycoplasma pneumoniae in Australia Open
View article: Targeted Culture-Independent Sequencing Identifies Emergence of Macrolide-Resistant<i>Bordetella Pertussis</i>in Australia
Targeted Culture-Independent Sequencing Identifies Emergence of Macrolide-Resistant<i>Bordetella Pertussis</i>in Australia Open
Bordetella pertussis continues to circulate globally despite wide-spread vaccination, with an emergent international epidemic in 2024. The resurgence of disease is confounded by the emergence of pertactin-deficient, macrolide-resistant B. …
View article: Hepatitis B Virus and Hepatitis C Virus Affect Mitochondrial Function Through Different Metabolic Pathways, Explaining Virus-Specific Clinical Features of Chronic Hepatitis
Hepatitis B Virus and Hepatitis C Virus Affect Mitochondrial Function Through Different Metabolic Pathways, Explaining Virus-Specific Clinical Features of Chronic Hepatitis Open
Background Hepatitis C virus (HCV) and hepatitis B virus (HBV) cause chronic hepatitis with important clinical differences. HCV causes hepatic steatosis and insulin resistance, while HBV confers increased risk of liver cancer. We hypothesi…
View article: Exploring synergy between azole antifungal drugs and statins for <i>Candida auris</i>
Exploring synergy between azole antifungal drugs and statins for <i>Candida auris</i> Open
Background Global emergence of rapidly developing resistance to multiple antifungal drugs and high mortality pose challenges to the treatment of invasive Candida auris infections. New therapeutic approaches are needed, such as repurposing …
View article: Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer
Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer Open
Polo-like kinase 1 (PLK1) is a regulator of cell mitosis and cytoskeletal dynamics. PLK1 overexpression in liver cancer is associated with tumour progression, metastasis, and vascular invasion. Hepatitis C virus (HCV) NS5A protein stimulat…
View article: PEMT Mediates Hepatitis C Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication
PEMT Mediates Hepatitis C Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication Open
The hepatitis C virus (HCV) relies on cellular lipid pathways for virus replication and also induces liver steatosis, but the mechanisms involved are not clear. We performed a quantitative lipidomics analysis of virus-infected cells by com…
View article: Development of a Real-Time PCR Assay to Identify and Distinguish between Cryptococcus neoformans and Cryptococcus gattii Species Complexes
Development of a Real-Time PCR Assay to Identify and Distinguish between Cryptococcus neoformans and Cryptococcus gattii Species Complexes Open
Cryptococcus neoformans and Cryptococcus gattii are the principle causative agents of cryptococcosis. Differences in epidemiological and clinical features, and also treatment, mean it is important for diagnostic laboratories to distinguish…
View article: Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals Open
View article: Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance
Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance Open
Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, but drug resistance could undermine proposed global elimination targets. Real‐world studies are needed to inform the impact of widespread DAA treatment …
View article: Macrophage Coordination of the Interferon Lambda Immune Response
Macrophage Coordination of the Interferon Lambda Immune Response Open
Lambda interferons (IFN-λs) are a major component of the innate immune defense to viruses, bacteria, and fungi. In human liver, IFN-λ not only drives antiviral responses, but also promotes inflammation and fibrosis in viral and non-viral d…
View article: The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer?
The Roles of p53 in Mitochondrial Dynamics and Cancer Metabolism: The Pendulum between Survival and Death in Breast Cancer? Open
Cancer research has been heavily geared towards genomic events in the development and progression of cancer. In contrast, metabolic regulation, such as aberrant metabolism in cancer, is poorly understood. Alteration in cellular metabolism …
View article: Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response
Hepatitis C Virus Driven AXL Expression Suppresses the Hepatic Type I Interferon Response Open
Treatment of chronic hepatitis C virus (HCV) infection is evolving rapidly with the development of novel direct acting antivirals (DAAs), however viral clearance remains intimately linked to the hepatic innate immune system. Patients demon…
View article: The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist
The Mechanism of Interferon Refractoriness During Hepatitis C Virus Infection and Its Reversal with a Peroxisome Proliferator-Activated Receptor α Agonist Open
Patients who respond poorly to therapies for hepatitis C virus (HCV) infection display a characteristic phenotype with high basal hepatic interferon-stimulated gene (ISG) expression, but limited induction following interferon (IFN) treatme…