Enping Xu
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View article: P644 Body composition does not predict clinical course in patients with acute severe ulcerative colitis
P644 Body composition does not predict clinical course in patients with acute severe ulcerative colitis Open
Background Acute Severe Ulcerative Colitis (ASUC) is a life-threatening complication of UC. Previous research has shown that body composition parameters, including sarcopaenia, are associated with outcomes in IBD. However, the relationship…
View article: AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis
AMER1 deficiency promotes the distant metastasis of colorectal cancer by inhibiting SLC7A11- and FTL-mediated ferroptosis Open
The crosstalk between ferroptosis and cancer metastasis remains unclear. Here, we identify AMER1 as a key regulator of ferroptosis. AMER1 loss causes resistance to ferroptosis in colorectal cancer (CRC) cells. Interestingly, AMER1-deficien…
View article: Data from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis
Data from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis Open
Background: We aimed to systematically summarize the diagnostic and prognostic value of circulating/tissue miR21 in patients with colorectal cancer.Methods: An original study was conducted to explore the potential value of circulating miR2…
View article: Supplementary Methods, Tables 1 - 6, Figures 1 - 3, PRISMA Checklist from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis
Supplementary Methods, Tables 1 - 6, Figures 1 - 3, PRISMA Checklist from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis Open
Supplementary Table 1 Instrument used for the evaluation of the risk of bias and applicability concerns of the included prognostic studies (adapted from QUADAS-2). Supplementary Table 2 Characteristics of studies included in the diagnostic…
View article: Data from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis
Data from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis Open
Background: We aimed to systematically summarize the diagnostic and prognostic value of circulating/tissue miR21 in patients with colorectal cancer.Methods: An original study was conducted to explore the potential value of circulating miR2…
View article: Supplementary Methods, Tables 1 - 6, Figures 1 - 3, PRISMA Checklist from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis
Supplementary Methods, Tables 1 - 6, Figures 1 - 3, PRISMA Checklist from Diagnostic and Prognostic Value of microRNA-21 in Colorectal Cancer: An Original Study and Individual Participant Data Meta-analysis Open
Supplementary Table 1 Instrument used for the evaluation of the risk of bias and applicability concerns of the included prognostic studies (adapted from QUADAS-2). Supplementary Table 2 Characteristics of studies included in the diagnostic…
View article: Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription
Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription Open
Precise and specific spatiotemporal domains of gene expression regulation are critical for embryonic development. Recent studies have identified GLTSCR1 as a gene transcriptional elongation regulator in cancer research. However, the functi…
View article: Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription
Loss of GLTSCR1 causes congenital heart defects by regulating NPPA transcription Open
Precise and specific spatiotemporal domains of gene expression regulation is critical for embryonic development. Recent studies have identified GLTSCR1 as a gene transcriptional elongation regulator in cancer research. However, the functio…
View article: GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression
GLTSCR1 coordinates alternative splicing and transcription elongation of ZO1 to regulate colorectal cancer progression Open
Alternative splicing (AS) and transcription elongation are vital biological processes, and their dysregulation causes multiple diseases, including tumors. However, the coregulatory mechanism of AS and transcription elongation in tumors rem…
View article: Research progress on application of microhaplotype in forensic genetics
Research progress on application of microhaplotype in forensic genetics Open
As a novel genetic marker, microhaplotype can be applied in the field of forensic genetics. Microhaplotype has the advantages of high polymorphism, low mutation rate, no stutter products and short amplification fragments. Microhaplotype ca…
View article: Investigation of the antidepressant effects of Shu-Gan-Jie- Yu granule and its mechanism of action
Investigation of the antidepressant effects of Shu-Gan-Jie- Yu granule and its mechanism of action Open
Purpose: To study the antidepressant effects of Shu-Gan-Jie-Yu granule (SJG) and its possible mechanisms in mice.Methods: The anti-depressive effects of SJG were evaluated by three techniques, viz, forced swimming test (FST), tail suspensi…
View article: RNF43 frameshift mutations contribute to tumourigenesis in right-sided colon cancer
RNF43 frameshift mutations contribute to tumourigenesis in right-sided colon cancer Open
The truncating mutations of RNF43 frequently occur in CRC, we aimed to clarify the relationship between RNF43 frameshift mutations and MS status, BRAF V600E mutation, distant metastasis, TNM stage and location of CRC. RNF43 frameshift muta…
View article: The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68
The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68 Open
CYTOR plays important roles in CRC progression by interacting with NCL and Sam68 and may serve as a prognostic biomarker and/or an effective target for CRC therapies.
View article: Additional file 4: of The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68
Additional file 4: of The long non-coding RNA CYTOR drives colorectal cancer progression by interacting with NCL and Sam68 Open
Figure S3. Funnel plots for the relationship between CYTOR and CRC prognosis. (A) Funnel plots of the association between CYTOR expression and overall survival at the cutoff value set according to the ROC. (B) Funnel plots of the associati…
View article: IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells
IL-13/STAT6 signaling plays a critical role in the epithelial-mesenchymal transition of colorectal cancer cells Open
Colorectal cancer (CRC) is one of the most common causes of cancer-related death worldwide due to the distant metastases. Compelling evidence has reported that epithelial-mesenchymal transition (EMT) is involved in promoting cancer invasio…
View article: <scp>HOTAIRM</scp>1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor
<span>HOTAIRM</span>1 as a potential biomarker for diagnosis of colorectal cancer functions the role in the tumour suppressor Open
Recent studies have revealed many different long noncoding RNA s (lnc RNA ), however, the investigation for their function and clinical value as tumour biomarkers has scarcely begun. Here, we found that expression of HOTAIRM 1 was reduced …
View article: Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer
Growth differentiation factor 15 is a promising diagnostic and prognostic biomarker in colorectal cancer Open
Although various studies have demonstrated that growth differentiation factor 15 ( GDF 15) might be a potential diagnostic and prognostic marker in colorectal cancer ( CRC ) patients, the results are inconsistent and the statistical power …
View article: [Association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma].
[Association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma]. Open
Neuroendocrine differentiation predicts deeper depth of invasion, more possibility of lymph node metastasis and poor survival in gastric adenocarcinoma.