Explanipedia

Diagnostic Accuracy of Coronary CT Angiography in Ruling Out Significant Coronary Artery Disease in Candidates for Transcatheter Aortic Valve Replacement Open

Chiara Gallo, Alfonso Campanile, Carmine Izzo, Sonia Paoletta, Valentina Russo , et al. · 2025

Obstructive coronary artery disease (CAD) is common in patients undergoing transcatheter aortic valve implantation (TAVI). While invasive coronary angiography (ICA) is the gold standard for coronary evaluation, coronary computed tomography…

A pilot study on DNA methylation changes for non‐invasive molecular diagnostics in heart failure Open

Giuditta Benincasa, Francesco Cacciatore, Mark E. Pepin, Francesco Curcio, Rosaria Chiappetti , et al. · 2025

Aims The current therapeutic approach to ischaemic (IsHF) and non‐ischaemic (NIsHF) heart failure (HF) mainly overlooks the underlying aetiology owing to a lack knowledge of the differential molecular pathways that contribute to HF with re…

DNA hypermethylation of MED1 and MED23 as early diagnostic biomarkers for unsolved issues in atrial fibrillation Open

Concetta Schiano, Teresa Infante, Giuditta Benincasa, Jacopo Burrello, Antonio Ruocco , et al. · 2025

For the first time, we showed that DNA methylation changes are associated with regulation of MED complex subunits in early diagnosis of AF patients. Clinically, MED1 and MED23 hypermethylation showed a diagnostic value not inferior to circ…

Sex-related differences among patients undergoing surgical aortic valve replacement—a propensity score matched study Open

Andreas Zierer, Ruggero De Paulis, Farhad Bakhtiary, Ali Ahmad, Martin Andreas , et al. · 2024

OBJECTIVES We investigated the sex-related difference in characteristics and 2-year outcomes after surgical aortic valve replacement (SAVR) by propensity-score matching (PSM). METHODS Data from 2 prospective registries, the INSPIRIS RESILI…

Beyond Medical Therapy—An Update on Heart Failure Devices Open

Luigi Falco, Fabio Valente, Aldo De Falco, Raffaele Barbato, Luigi Marotta , et al. · 2024

Heart failure (HF) is a complex and progressive disease marked by substantial morbidity and mortality rates, frequent episodes of decompensation, and a reduced quality of life (QoL), with severe financial burden on healthcare systems. In r…

Analyzing Pre-operative Hospital Stay and Incidence of Hospital Acquired Infection: A Retrospective Study Open

Maria Costantino, Ornella Piazza, Enrico Coscioni, Emilia Anna Vozzella, Walter Longanella , et al. · 2024

The duration of pre-operative hospital stays is pivotal in HCAI risk. Prospective multicenter studies are needed for validation, which is crucial for enhancing patient safety and treatment efficacy.

MECHANICAL HEART VALVES AND ORAL ANTICOAGULATION: A SURVEY OF THE ITALIAN SOCIETY OF CARDIAC SURGERY Open

Giuseppe Santarpino, Michele Di Mauro, Marisa De Feo, Lorenzo Menicanti, Domenico Paparella , et al. · 2024

In the latest European guidelines for the management of valvular heart disease, mechanical valve prostheses maintain a strategic role, particularly for certain patient subsets and age groups. Despite the high number of devices implanted in…

Recent Advances across the Spectrum of Heart Failure and Heart Transplant Open

Daniele Masarone, Carlo Lombardi, Luigi Falco, Enrico Coscioni, Marco Metra · 2024

In recent years, remarkable progress has been accomplished in the heart failure (HF) landscape, with novel drugs and groundbreaking device approaches [...]

DNA methylation profiling of circulating CD4+ T cells and network analysis reveal that JUNB, SETD7, and MEF2D genes predict patients with heart failure preserved vs. reduced ejection fraction Open

Giuditta Benincasa, Mark E. Pepin, Francesco Cacciatore, Vincenzo Russo, Michele D’Alto , et al. · 2023

Background Heart failure (HF) with preserved ejection fraction (HFpEF) represents about 50% of new HF diagnosis but still lacks specific biomarkers and effective therapy. Epigenetic-sensitive changes accumulated over time, mainly guided by…

Longitudinal Trajectory Modeling to Assess Adherence to Sacubitril/Valsartan among Patients with Heart Failure Open

Sara Mucherino, Alexandra L. Dima, Enrico Coscioni, Maria Giovanna Vassallo, Valentina Orlando , et al. · 2023

Medication adherence in chronic conditions is a long-term process. Modeling longitudinal trajectories using routinely collected prescription data is a promising method for describing adherence patterns and identifying at-risk groups. The s…

Thromboembolic Events after COVID-19 Vaccination: An Italian Retrospective Real-World Safety Study Open

Francesca Futura Bernardi, Annamaria Mascolo, Marina Sarno, Nicolina Capoluongo, Ugo Trama , et al. · 2023

Introduction: Real-world safety studies can provide important evidence on the thromboembolic risk associated with COVID-19 vaccines, considering that millions of people have been already vaccinated against COVID-19. In this study, we aimed…

Thromboembolic Events after COVID-19 Vaccination: An Italian Retrospective Real-World Safety Study Open

Francesca furtura Bernardi, Annamaria Mascolo, Marina Sarno, Nicolina Capoluongo, Ugo Trama , et al. · 2023

Introduction: Real-world safety studies can provide important evidence on the thromboembolic risk associated with COVID-19 vaccines, considering that millions of people have been already vaccinated against COVID-19. In this study, we aimed…

Air pollution and cardiovascular disease: state of art and control strategies within “One Health” approach Open

Lucia D'Elia, A. Longobardi, Francesco Pirozzi, A Bonadies, Maria Immacolata Spagnuolo , et al. · 2023

Environmental quality is closely related to human health. In recent years, the growing awareness has led to the definition of an integrated "One Health" approach to protect simultaneously environment, humans and animals. Poor air quality i…

Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years — 1-year follow-up from the prospective INDURE registry Open

Bart Meuris, Jean‐Christian Roussel, Michael A. Borger, Matthias Siepe, Pierluigi Stefàno , et al. · 2023

OBJECTIVES We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS The INSPIRIS RESILIA Durability Registry is a prospective, multicentre registry to asses…

Artificial intelligence, big data and heart transplantation: Actualities Open

Vittorio Palmieri, Andrea Montisci, Maria Teresa Vietri, P.C. Colombo, Sílvia Carbonell Sala , et al. · 2023

P192 POSTINFARCTION VENTRICULAR SEPTAL DEFECT: MANAGEMENT AND A NEW SURGICAL OPTION FOR CLOSURE Open

Michele La Torre, Cesare Baldi, Pompea Bottiglieri, Mario Vassallo, Tiziana Attisano , et al. · 2023

Postinfarction ventricular septal defect is a rare mechanical complication of myocardial infarction, with difficult management, debated closure timing and high mortality rates. Standard repair techniques – infarcectomy and infarct exclusio…

P406 LAUBRY–PEZZI SYNDROME: EVERYTHING IS NOT AS IT SEEMS Open

Maria Vincenza Polito, G Cannavaro, F D’Auria, Pompea Bottiglieri, Michael Vassallo , et al. · 2023

Introduction Laubry–Pezzi syndrome is a congenital heart disease characterized by the prolapse of an aortic valve cusp into a subjacent ventricular septal defect (VSD), mostly supracristal, leading to severe aortic regurgitation (AR). It h…

Cardiotoxicity, Cardioprotection, and Prognosis in Survivors of Anticancer Treatment Undergoing Cardiac Surgery: Unmet Needs Open

Vittorio Palmieri, Maria Teresa Vietri, Andrea Montalto, Andrea Montisci, Francesco Donatelli , et al. · 2023

Background: Anticancer treatments are improving the prognosis of patients fighting cancer. However, anticancer treatments may also increase the cardiovascular (CV) risk by increasing metabolic disorders. Atherosclerosis and atherothrombosi…

Postinfarction ventricular septal defect: A new surgical option without left ventriculotomy Open

Mario Torre, Antonio Longobardi, Maria Giovanna Vassallo, Guido Oppido, Enrico Coscioni · 2023

Central MessageSuccessful PSVD closure parachuting 2 composite handmade patches through the AV and the TV, without LVT. It is feasible, simple, and provides good results at 4-months follow-up. Successful PSVD closure parachuting 2 composit…

An evidence-based debate on epigenetics and immunosenescence in COVID-19 Open

Claudio Napoli, Enrico Coscioni, Ugo Trama, Maria Grazia Strozziero, Giuditta Benincasa · 2023

Immunosenescence contributes to the decline of immune function leading to a reduced ability to respond to severe coronavirus disease 2019 (COVID-19) in elderly patients. Clinical course of COVID-19 is widely heterogeneous and guided by the…

1112 DOUBLE RUPTURE OF INTERVENTRICULAR SEPTUM AFTER MYOCARDIAL INFARCTION Open

Davide Bonadies, Giovanna Carpentiero, Rossana Palumbo, Alma Grossi, Mario Cristiano , et al. · 2022

Ventricular septal rupture (VSR) is a mechanical complication of acute myocardial infarction (MI). VSR and early surgical repair is associated with a high mortality rate and suboptimal results with frequent postoperative residual shunt. Ra…

Autoantibodies to IgE can induce the release of proinflammatory and vasoactive mediators from human cardiac mast cells Open

Remo Poto, Vincenzo Patella, Gjada Criscuolo, Gianni Marone, Enrico Coscioni , et al. · 2022

Risk of SARS-CoV-2 Infection Breakthrough among the Non-Vaccinated and Vaccinated Population in Italy: A Real-World Evidence Study Based on Big Data Open

Alessandro Perrella, Massimo Bisogno, Angelo D’Argenzio, Ugo Trama, Enrico Coscioni , et al. · 2022

SARS-CoV-2 infection after vaccination can occur because COVID-19 vaccines do not offer 100% protection. The study aim was to assess duration of vaccination coverage, disease symptoms and type of hospitalization among non-vaccinated and va…

Postvaccination SARS-CoV-2 Infections among Healthcare Professionals: A Real World Evidence Study Open

Alessandro Perrella, Sara Mucherino, Ilaria Guarino, Mariagiovanna Nerilli, Alberto Enrico Maraolo , et al. · 2022

Due to the COVID-19 pandemic, all countries with a global mobilization started to produce and authorize vaccines, prioritizing healthcare professionals (HCPs) to reduce transmission. The aim of this study was to assess post-vaccination inf…

SARS-CoV-2 Infection Breakthrough among the non-vaccinated and vaccinated: a Real World Evidence study based on Big Data Open

Alessandro Perrella, Marco Bisogno, D’Argenzio, Ugo Trama, Enrico Coscioni , et al. · 2022

Background SARS-CoV-2 infection after vaccination can occur because COVID-19 vaccines do not offer 100% protection. The aim of this study was to assess vaccination coverage among people nasopharyngeal swabs, disease symptoms and type of ho…

Esophageal-pleural fistula after intraoperative transoesophageal echocardiography in a patient with enlarged left atrium Open

Mario Torre, Antonio Longobardi, David Ferrara, David Ferrara, Maria Giovanna Vassallo , et al. · 2022

After mitral valve replacement in an 81-year-old woman, there was evidence of an important communication between the esophagus and the right pleura. Diagnosis was confirmed with Oral Gastrografin radiography and esophagoscopy. Thoracic com…

COVID-19 response: effectiveness of weekly rapid risk assessments, Italy Open

Flavia Riccardo, Giorgio Guzzetta, Alberto Mateo‐Urdiales, Martina Del Manso, Xanthi Andrianou , et al. · 2022

COVID-19 response: effectiveness of weekly rapid risk assessments, Italy Open

Flavia Riccardo, Giorgio Guzzetta, Alberto Mateo‐Urdiales, Martina Del Manso, Xanthi Andrianou , et al. · 2022

Although the system worked well, framing the risk assessment tool in a legal decree hampered its flexibility, as indicators could not be changed without changing the law. The relative complexity of the tool, the impossibility of real-time …

Machine Learning and Bioinformatics Framework Integration to Potential Familial DCM-Related Markers Discovery Open

Concetta Schiano, Monica Franzese, Filippo Geraci, Mario Zanfardino, Ciro Maiello , et al. · 2021

Objectives: Dilated cardiomyopathy (DCM) is characterized by a specific transcriptome. Since the DCM molecular network is largely unknown, the aim was to identify specific disease-related molecular targets combining an original machine lea…

Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy Open

Kevin Bliek-Bueno, Sara Mucherino, Beatriz Poblador‐Plou, Francisca González‐Rubio, Mercedes Aza‐Pascual‐Salcedo , et al. · 2021

This study aims to identify baseline medications that, as a proxy for the diseases they are dispensed for, are associated with increased risk of mortality in COVID-19 patients from two regions in Spain and Italy using real-world data. We c…

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