Enrico Dall’Ara
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View article: Quantifying the local strain energy density distribution in the mouse tibia: the critical role of the loading direction
Quantifying the local strain energy density distribution in the mouse tibia: the critical role of the loading direction Open
Understanding how bone adapts to external forces is fundamental for exploring potential biomechanical interventions against skeletal diseases. This can be studied preclinically, combining in vivo experiments in rodents and in silico mechan…
View article: An overview of reliable and representative DVC measurements for musculoskeletal tissues
An overview of reliable and representative DVC measurements for musculoskeletal tissues Open
Musculoskeletal tissues present complex hierarchical structures and mechanical heterogeneity across multiple length scales, making them difficult to characterise accurately. Digital volume correlation (DVC) is a non‐destructive imaging tec…
View article: Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion
Intervertebral disc degeneration increases surface strain on metastatic vertebrae in compression and flexion but not in torsion Open
Despite the fundamental role of intervertebral discs (IVDs) in the biomechanics of the spine, their condition has never been considered among the possible factors affecting the mechanical behaviour of metastatic vertebrae. The structure of…
View article: Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements
Comparing the predictions of CT-based subject-specific finite element models of human metastatic vertebrae with digital volume correlation measurements Open
Several conditions can increase the incidence of vertebral fragility fractures, including metastatic bone disease. Computational tools could help clinicians estimate the risk of vertebral fracture in these patients; however, comparison wit…
View article: Altered vertebral biomechanical properties in prostate cancer patients following androgen deprivation therapy
Altered vertebral biomechanical properties in prostate cancer patients following androgen deprivation therapy Open
Androgen deprivation therapy (ADT) for localised and metastatic prostate cancer (PCa) is known to improve survival in patients but has been associated with negative long-term impacts on the skeleton, including decreased bone mineral densit…
View article: Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies
Degeneration of the nucleus pulposus affects the internal volumetric strains and failure location of adjacent human metastatic vertebral bodies Open
Intervertebral disc (IVD) degeneration is suspected to affect the distribution of stress and strain near the vertebral endplates and in the underlying bone. This scenario is worsened by the presence of metastatic lesions on the vertebrae (…
View article: Microstructure of the human metastatic vertebral body
Microstructure of the human metastatic vertebral body Open
Introduction Bone spinal metastases disrupt the bone homeostasis, inducing a local imbalance in the bone formation and/or resorption, with consequent loss of the structural optimisation of the vertebrae and increase of the risk of fracture…
View article: Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs)
Fabrication of hierarchically porous trabecular bone replicas via 3D printing with high internal phase emulsions (HIPEs) Open
Combining emulsion templating with additive manufacturing enables the production of inherently porous scaffolds with multiscale porosity. This approach incorporates interconnected porous materials, providing a structure that supports cell …
View article: A novel framework for elucidating the effect of mechanical loading on the geometry of ovariectomized mouse tibiae using principal component analysis
A novel framework for elucidating the effect of mechanical loading on the geometry of ovariectomized mouse tibiae using principal component analysis Open
Introduction Murine models are used to test the effect of anti-osteoporosis treatments as they replicate some of the bone phenotypes observed in osteoporotic (OP) patients. The effect of disease and treatment is typically described as chan…
View article: A novel mean shape based post-processing method for enhancing deep learning lower-limb muscle segmentation accuracy
A novel mean shape based post-processing method for enhancing deep learning lower-limb muscle segmentation accuracy Open
This study aims at improving the lower-limb muscle segmentation accuracy of deep learning approaches based on Magnetic Resonance Imaging (MRI) scans, crucial for the diagnostic and therapeutic processes in musculoskeletal diseases. In gene…
View article: Data-driven image mechanics (D2IM): A deep learning approach to predict displacement and strain fields from undeformed X-ray tomography images – Evaluation of bone mechanics
Data-driven image mechanics (D2IM): A deep learning approach to predict displacement and strain fields from undeformed X-ray tomography images – Evaluation of bone mechanics Open
The recent advent of deep learning (DL) has enabled data-driven models to pave the way for the full exploitation of rich image datasets from which physics can be learnt. Here we propose a novel data-driven image mechanics (D2IM) approach t…
View article: Automatic segmentation of lower limb muscles from MR images of post-menopausal women based on deep learning and data augmentation
Automatic segmentation of lower limb muscles from MR images of post-menopausal women based on deep learning and data augmentation Open
Individual muscle segmentation is the process of partitioning medical images into regions representing each muscle. It can be used to isolate spatially structured quantitative muscle characteristics, such as volume, geometry, and the level…
View article: Automatic segmentation of skeletal muscles from MR images using modified U-Net and a novel data augmentation approach
Automatic segmentation of skeletal muscles from MR images using modified U-Net and a novel data augmentation approach Open
Rapid and accurate muscle segmentation is essential for the diagnosis and monitoring of many musculoskeletal diseases. As gold standard, manual annotation suffers from intensive labor and high inter-operator reproducibility errors. In this…
View article: Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation
Validation of homogenized finite element models of human metastatic vertebrae using digital volume correlation Open
The incidence of vertebral fragility fracture is increased by the presence of preexisting pathologies such as metastatic disease. Computational tools could support the fracture prediction and consequently the decision of the best medical t…
View article: The loading direction dramatically affects the mechanical properties of the mouse tibia
The loading direction dramatically affects the mechanical properties of the mouse tibia Open
Introduction: The in vivo tibial loading mouse model has been extensively used to evaluate bone adaptation in the tibia after mechanical loading treatment. However, there is a prevailing assumption that the load is applied axially to the t…
View article: Symmetric Normalization Algorithm for Estimating Physiological Strain in Bones
Symmetric Normalization Algorithm for Estimating Physiological Strain in Bones Open
View article: Digital Volume Correlation Analysis of Paraphysiological Deformation of Whole Human Bones Using Symmetric Normalization Registration Method
Digital Volume Correlation Analysis of Paraphysiological Deformation of Whole Human Bones Using Symmetric Normalization Registration Method Open
View article: Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice
Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice Open
Combined treatment with PTH(1‐34) and mechanical loading confers increased structural benefits to bone than monotherapies. However, it remains unclear how this longitudinal adaptation affects the bone mechanics. This study quantified the i…
View article: Cortical thickness adaptation to combined mechanical loading and parathyroid hormone treatments is site specific and synergistic in the mouse tibia model
Cortical thickness adaptation to combined mechanical loading and parathyroid hormone treatments is site specific and synergistic in the mouse tibia model Open
In this study, we aimed to quantify the localised effects of mechanical loading (ML), low (20 μg/kg/day), moderate (40 μg/kg/day) or high (80 μg/kg/day) dosages of parathyroid hormone (PTH), and combined (PTHML) treatments on cortical bone…
View article: Cortical bone adaptation response is region specific, but not peak load dependent: insights from $$\mu$$CT image analysis and mechanostat simulations of the mouse tibia loading model
Cortical bone adaptation response is region specific, but not peak load dependent: insights from $$\mu$$CT image analysis and mechanostat simulations of the mouse tibia loading model Open
The two major aims of the present study were: (i) quantify localised cortical bone adaptation at the surface level using contralateral endpoint imaging data and image analysis techniques, and (ii) investigate whether cortical bone adaptati…
View article: Unlocking the power of computational modelling and simulation across the product lifecycle in life sciences: A UK Landscape Report
Unlocking the power of computational modelling and simulation across the product lifecycle in life sciences: A UK Landscape Report Open
This report Outlines the public health and economic benefits of using in silico technologies (ISTs) to refine, reduce, and even replace the need for conventional human clinical trials and animal and physical testing in the…
View article: Unlocking the power of computational modelling and simulation across the product lifecycle in life sciences: A UK Landscape Report
Unlocking the power of computational modelling and simulation across the product lifecycle in life sciences: A UK Landscape Report Open
This report Outlines the public health and economic benefits of using in silico technologies (ISTs) to refine, reduce, and even replace the need for conventional human clinical trials and animal and physical testing in the development of n…
View article: The role of bone metastases on the mechanical competence of human vertebrae
The role of bone metastases on the mechanical competence of human vertebrae Open
Spine is the most common site for bone metastases. The evaluation of the mechanical competence and failure location in metastatic vertebrae is a biomechanical and clinical challenge. Little is known about the failure behaviour of vertebrae…
View article: Prediction of the 3D shape of the L1 vertebral body from adjacent vertebrae
Prediction of the 3D shape of the L1 vertebral body from adjacent vertebrae Open
The aim of treatments of vertebral fractures is the anatomical reduction to restore the physiological biomechanics of the spine and the stabilization of the fracture to allow bone healing. However, the three-dimensional shape of the fractu…
View article: Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm
Bone metastases do not affect the measurement uncertainties of a global digital volume correlation algorithm Open
Introduction: Measurement uncertainties of Digital Volume Correlation (DVC) are influenced by several factors, like input images quality, correlation algorithm, bone type, etc. However, it is still unknown if highly heterogeneous trabecula…
View article: Deformable image registration based on single or multi-atlas methods for automatic muscle segmentation and the generation of augmented imaging datasets
Deformable image registration based on single or multi-atlas methods for automatic muscle segmentation and the generation of augmented imaging datasets Open
Muscle segmentation is a process relied upon to gather medical image-based muscle characterisation, useful in directly assessing muscle volume and geometry, that can be used as inputs to musculoskeletal modelling pipelines. Manual or semi-…
View article: Accuracy of in vivo microCT imaging in assessing the microstructural properties of the mouse tibia subchondral bone
Accuracy of in vivo microCT imaging in assessing the microstructural properties of the mouse tibia subchondral bone Open
Osteoarthritis (OA) is one of the most common musculoskeletal diseases. OA is characterized by degeneration of the articular cartilage as well as the underlying subchondral bone. Post-traumatic osteoarthritis (PTOA) is a subset of OA cause…
View article: Comparison of linear and nonlinear stepwise μFE displacement predictions to digital volume correlation measurements of trabecular bone biopsies
Comparison of linear and nonlinear stepwise μFE displacement predictions to digital volume correlation measurements of trabecular bone biopsies Open
Digital volume correlation (DVC) enables to evaluate the ability of μFE models in predicting experimental results on the mesoscale. In this study predicted displacement fields of three different linear and materially nonlinear μFE simulati…
View article: Effect of radiation-induced damage of trabecular bone tissue evaluated using indentation and digital volume correlation
Effect of radiation-induced damage of trabecular bone tissue evaluated using indentation and digital volume correlation Open
Exposure to X-ray radiation for an extended amount of time can cause damage to the bone tissue and therefore affect its mechanical properties. Specifically, high-resolution X-ray Computed Tomography (XCT), in both synchrotron and lab-based…
View article: Editorial: Computational modeling for the assessment of the biomechanical properties of the healthy, diseased and treated spine
Editorial: Computational modeling for the assessment of the biomechanical properties of the healthy, diseased and treated spine Open
EDITORIAL article Front. Bioeng. Biotechnol., 11 October 2022Sec. Biomechanics Volume 10 - 2022 | https://doi.org/10.3389/fbioe.2022.1016311