Enrico Leipold
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View article: Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials
Nociceptor sodium channels shape subthreshold phase, upstroke, and shoulder of action potentials Open
Voltage-gated sodium channels (VGSCs) in the peripheral nervous system shape action potentials (APs) and thereby support the detection of sensory stimuli. Most of the nine mammalian VGSC subtypes are expressed in nociceptors, but predomina…
View article: NaV1.8/NaV1.9 double deletion mildly affects acute pain responses in mice
NaV1.8/NaV1.9 double deletion mildly affects acute pain responses in mice Open
The 2 tetrodotoxin-resistant (TTXr) voltage-gated sodium channel subtypes Na V 1.8 and Na V 1.9 are important for peripheral pain signaling. As determinants of sensory neuron excitability, they are essential for the initial transduction of…
View article: Satellite glial cells from adult DRG dedifferentiate<i>in vitro</i>and can be reprogrammed into nociceptor-like neurons
Satellite glial cells from adult DRG dedifferentiate<i>in vitro</i>and can be reprogrammed into nociceptor-like neurons Open
Loss of sensory neurons in the dorsal root ganglia (DRG) may be a cause of neuropathic pain following traumatic nerve lesion or surgery. To regenerate peripheral sensory neurons, satellite glial cells (SGCs) may be an attractive endogenous…
View article: Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies
Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies Open
Congenital insensitivity to pain (CIP) and hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders exclusively or predominantly affecting the sensory and autonomic neurons. Due to the rar…
View article: Sodium channels expressed in nociceptors contribute distinctly to action potential subthreshold phase, upstroke and shoulder
Sodium channels expressed in nociceptors contribute distinctly to action potential subthreshold phase, upstroke and shoulder Open
Voltage-gated sodium channels (VGSC) in the peripheral nervous system shape action potentials (AP) and thereby support the detection of sensory stimuli. Most of the nine mammalian VGSC subtypes are expressed in nociceptors, but predominant…
View article: Isolation and transfection of myenteric neurons from mice for patch-clamp applications
Isolation and transfection of myenteric neurons from mice for patch-clamp applications Open
The enteric nervous system (ENS) is a complex neuronal network organized in ganglionated plexuses that extend along the entire length of the gastrointestinal tract. Largely independent of the central nervous system, the ENS coordinates mot…
View article: Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase
Electrophysiological Properties of Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons Correlate With Expression of Tyrosine Hydroxylase Open
Induced pluripotent stem cell (iPSC)-based generation of tyrosine hydroxylase-positive (TH + ) dopaminergic neurons (DNs) is a powerful method for creating patient-specific in vitro models to elucidate mechanisms underlying Parkinson’s dis…
View article: Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers
Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers Open
Cyclic µ-conotoxin PIIIA, a potent blocker of skeletal muscle voltage-gated sodium channel NaV1.4, is a 22mer peptide stabilized by three disulfide bonds. Combining electrophysiological measurements with molecular docking and dynamic simul…
View article: Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors
Where cone snails and spiders meet: design of small cyclic sodium‐channel inhibitors Open
A 13 aa residue voltage‐gated sodium (Na v ) channel inhibitor peptide, Pn, containing 2 disulfide bridges was designed by using a chimeric approach. This approach was based on a common pharmacophore deduced from sequence and secondary str…
View article: NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions
NaV1.9 Potentiates Oxidized Phospholipid-Induced TRP Responses Only under Inflammatory Conditions Open
Oxidized phospholipids (OxPL) like oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (OxPAPC) were recently identified as novel proalgesic targets in acute and chronic inflammatory pain. These endogenous chemical irritants ar…
View article: New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives
New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives Open
Cold temperature detection involves the process of sensory transduction in cutaneous primary sensory nerve terminals, which converts thermal stimuli into depolarizations of the membrane. This transformation into electrical signals is follo…