Enrico Munari
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View article: The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes
The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes Open
Innate immunity is the first line of defense against infections, including the detection and response to SARS-CoV-2. Cells of the innate system are usually activated within hours after pathogen exposure and do not generate conventional imm…
View article: A Multicentric Dataset for Training and Benchmarking Breast Cancer Segmentation in H&E Slides
A Multicentric Dataset for Training and Benchmarking Breast Cancer Segmentation in H&E Slides Open
Automated semantic segmentation of whole-slide images (WSIs) stained with hematoxylin and eosin (H&E) is essential for large-scale artificial intelligence-based biomarker analysis in breast cancer. However, existing public datasets for bre…
View article: Attention-Based Whole-Slide Image Compression Achieves Pathologist-Level Prescreening of Multiorgan Routine Histopathology Biopsies
Attention-Based Whole-Slide Image Compression Achieves Pathologist-Level Prescreening of Multiorgan Routine Histopathology Biopsies Open
Screening programs for the early detection of cancers, such as colorectal and cervical cancers, have led to an increased demand for histopathological analysis of biopsies. Advanced image analysis with deep learning has shown the potential …
View article: Tumor-infiltrating lymphocytes in breast cancer through artificial intelligence: biomarker analysis from the results of the TIGER challenge
Tumor-infiltrating lymphocytes in breast cancer through artificial intelligence: biomarker analysis from the results of the TIGER challenge Open
The prognostic significance of tumor-infiltrating lymphocytes (TILs) in breast cancer has been recognized for over a decade. Although histology-based scoring recommendations exist to standardize visual TILs assessment, interobserver agreem…
View article: The expanding role of next-generation imaging in prostate cancer management: a cross-sectional survey exploring the clinical practice of uro-oncologists in North-Eastern Italy; on behalf of GUONE (Gruppo Uro-Oncologico del Nord-Est)
The expanding role of next-generation imaging in prostate cancer management: a cross-sectional survey exploring the clinical practice of uro-oncologists in North-Eastern Italy; on behalf of GUONE (Gruppo Uro-Oncologico del Nord-Est) Open
Background: Next-generation imaging (NGI) technologies such as multiparametric magnetic resonance imaging (mpMRI) and total-body NGI (tbNGI) methodologies including choline, fluciclovine or PSMA positron emission tomography/computed tomogr…
View article: T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma
T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma Open
Neuroblastoma (NB) is an immunologically “cold” tumor with poor or no inflamed substrates as most of solid pediatric tumors (SPT). Consistent data indicate that NB tumor microenvironment (TME) is dominated by myeloid cells, with little (bu…
View article: Attention-based whole-slide image compression achieves pathologist-level pre-screening of multi-organ routine histopathology biopsies
Attention-based whole-slide image compression achieves pathologist-level pre-screening of multi-organ routine histopathology biopsies Open
Screening programs for early detection of cancer such as colorectal and cervical cancer have led to an increased demand for histopathological analysis of biopsies. Advanced image analysis with Deep Learning has shown the potential to autom…
View article: Generating and evaluating synthetic data in digital pathology through diffusion models
Generating and evaluating synthetic data in digital pathology through diffusion models Open
Synthetic data is becoming a valuable tool for computational pathologists, aiding in tasks like data augmentation and addressing data scarcity and privacy. However, its use necessitates careful planning and evaluation to prevent the creati…
View article: Histopathological evaluation and grading for prostate cancer: current issues and crucial aspects
Histopathological evaluation and grading for prostate cancer: current issues and crucial aspects Open
A crucial aspect of prostate cancer grading, especially in low- and intermediate-risk cancer, is the accurate identification of Gleason pattern 4 glands, which includes ill-formed or fused glands. However, there is notable inconsistency am…
View article: Human NK cells and cancer
Human NK cells and cancer Open
The long story of NK cells started about 50 y ago with the first demonstration of a natural cytotoxic activity within an undefined subset of circulating leukocytes, has involved an ever-growing number of researchers, fascinated by the appa…
View article: CD34+DNAM-1brightCXCR4+ haemopoietic precursors circulate after chemotherapy, seed lung tissue and generate functional innate-like T cells and NK cells
CD34+DNAM-1brightCXCR4+ haemopoietic precursors circulate after chemotherapy, seed lung tissue and generate functional innate-like T cells and NK cells Open
Background There is little information on the trajectory and developmental fate of Lin - CD34 + DNAM-1 bright CXCR4 + progenitors exiting bone marrow during systemic inflammation. Objective To study Lin - CD34 + DNAM-1 bright CXCR4 + cell …
View article: TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma
TROP-2, NECTIN-4 and predictive biomarkers in sarcomatoid and rhabdoid bladder urothelial carcinoma Open
Sarcomatoid and rhabdoid BUC do harbor positive expression of the ADC targets TROP-2 or NECTIN-4 in a relatively modest subset of cases, whereas the majority do not. Different combinations of other positive biomarkers may help the choice o…
View article: Pathological Complete Response to Pembrolizumab plus Axitinib Combination following Serious Immune-Related Adverse Events in an Advanced Renal Cell Carcinoma Patient with a History of Rheumatoid Arthritis
Pathological Complete Response to Pembrolizumab plus Axitinib Combination following Serious Immune-Related Adverse Events in an Advanced Renal Cell Carcinoma Patient with a History of Rheumatoid Arthritis Open
Immune checkpoint inhibitors (ICIs)-based combinations have improved survival outcomes of advanced renal cell carcinoma (RCC) patients and are currently recommended as first-line treatment options. Rheumatoid arthritis (RA) is a systemic a…
View article: Supplementary Material for: PATHOLOGICAL COMPLETE RESPONSE TO PEMBROLIZUMAB PLUS AXITINIB COMBINATION FOLLOWING SERIOUS IMMUNE-RELATED ADVERSE EVENTS IN AN ADVANCED RENAL CELL CARCINOMA PATIENT WITH A HISTORY OF RHEUMATOID ARTHRITIS
Supplementary Material for: PATHOLOGICAL COMPLETE RESPONSE TO PEMBROLIZUMAB PLUS AXITINIB COMBINATION FOLLOWING SERIOUS IMMUNE-RELATED ADVERSE EVENTS IN AN ADVANCED RENAL CELL CARCINOMA PATIENT WITH A HISTORY OF RHEUMATOID ARTHRITIS Open
Introduction Immune checkpoint inhibitors (ICIs)-based combinations have improved survival outcomes of advanced renal cell carcinoma (RCC) patients and are currently recommended as first-line treatment options. Rheumatoid arthritis (RA) is…
View article: Natural Language Processing to extract SNOMED-CT codes from pathological reports
Natural Language Processing to extract SNOMED-CT codes from pathological reports Open
AI tools allow the automatic SNOMED-CT labeling of the pathology archives, providing a retrospective fix to the large lack of organization of narrative reports.
View article: Generating synthetic data in digital pathology through diffusion models: a multifaceted approach to evaluation
Generating synthetic data in digital pathology through diffusion models: a multifaceted approach to evaluation Open
Synthetic data has recently risen as a new precious item in the computational pathologist’s toolbox, supporting several tasks such as helping with data scarcity or augmenting training set in deep learning. Nonetheless, the use of such nove…
View article: PROACTING: predicting pathological complete response to neoadjuvant chemotherapy in breast cancer from routine diagnostic histopathology biopsies with deep learning
PROACTING: predicting pathological complete response to neoadjuvant chemotherapy in breast cancer from routine diagnostic histopathology biopsies with deep learning Open
Background Invasive breast cancer patients are increasingly being treated with neoadjuvant chemotherapy; however, only a fraction of the patients respond to it completely. To prevent overtreatment, there is an urgent need for biomarkers to…
View article: Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells
Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells Open
NK cells represent important effectors that play a major role in innate defences against pathogens and display potent cytolytic activity against tumor cells. An array of surface receptors finely regulate their function and inhibitory check…
View article: Delphi expert consensus for whole slide imaging in thyroid cytopathology
Delphi expert consensus for whole slide imaging in thyroid cytopathology Open
Objective Despite an increase in thyroid fine needle aspiration (FNA) and advances in whole slide imaging (WSI) adoption, digital pathology is still considered inadequate for primary diagnosis of these cases. Herein, we aim to validate the…
View article: Cost analysis of archives in the pathology laboratories: from safety to management
Cost analysis of archives in the pathology laboratories: from safety to management Open
Context Despite the reluctance to invest and the challenging estimation of necessary supporting costs, optimising the archives seems to be one of the hottest topics in the future management of the pathology laboratories. Historically, arch…
View article: The roles of different forms of IL-15 in human melanoma progression
The roles of different forms of IL-15 in human melanoma progression Open
Background Melanoma is a lethal skin cancer, and the risk of developing it is increased by exposure to ultraviolet (UV) radiation. The production of cytokines such as interleukin-15 (IL-15), induced by the exposure of skin cells to UV rays…
View article: Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy
Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy Open
Cancer stem cells (CSC) are highly resistant to conventional chemotherapeutic drugs. YAP1 and STAT3 are the two transcription factors that facilitate the therapeutic resistance and expansion of CSCs. The objective of this study was to unde…
View article: Supplementary Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy
Supplementary Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy Open
This is a file of "Supplementary Data".
View article: Supplementary Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy
Supplementary Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy Open
This is a file of "Supplementary Data".
View article: Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy
Data from Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy Open
Cancer stem cells (CSC) are highly resistant to conventional chemotherapeutic drugs. YAP1 and STAT3 are the two transcription factors that facilitate the therapeutic resistance and expansion of CSCs. The objective of this study was to unde…
View article: Table S3 from NK-cell Editing Mediates Epithelial-to-Mesenchymal Transition via Phenotypic and Proteomic Changes in Melanoma Cell Lines
Table S3 from NK-cell Editing Mediates Epithelial-to-Mesenchymal Transition via Phenotypic and Proteomic Changes in Melanoma Cell Lines Open
Supplementary Table S3