Explanipedia

Wastewater Parvovirus B19 Signal Amid Rising Maternal Cases Open

Justin R. Clark, Michael J. Tisza, Alexandra Hammerquist, Harihara Prakash, Jessian L. Munoz , et al. · 2025

We report widespread detection of parvovirus B19 in Texas Wastewater using hybrid-capture virome sequencing across 43 sites. Wastewater signal correlated with clinical cases at institutional, county, and state levels and preceded case surg…

Elevated Micro- and Nanoplastics Detected in Preterm Human Placentae Open

Michael D. Jochum, Marcus Garcia, Alexandra Hammerquist, J.McC. Howell, Matthew S. Stanford , et al. · 2025

Recent analytical advancements have uncovered increasing micro- and nanoplastics (MNPs) in environmental, dietary, and biological domains, raising concerns about their health impacts. Preterm birth (PTB), a leading cause of maternal and ne…

Discrete placental gene expression signatures accompany diabetic disease classifications during pregnancy Open

Enrico R. Barrozo, Diana Racusin, Michael D. Jochum, Brandon T. Garcia, Melissa Suter , et al. · 2024

Consistent with the distinct association of perinatal outcome risk, placentae from GDMA1, GDMA2, and T2DM-affected pregnancies harbor unique gene signatures that can be further distinguished by altered placental cellular subtypes and micro…

Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry Open

Marcus A. Garcia, Rui Liu, Alexander Nihart, Eliane El Hayek, Eliseo F. Castillo , et al. · 2024

The exponential increase in global plastic usage has led to the emergence of nano- and microplastic (NMP) pollution as a pressing environmental issue due to its implications for human and other mammalian health. We have developed methodolo…

33 Bioaccumulation of Microplastics in Placentae Associated with Environmental Chemical Exposures and Obstetrical Outcomes Open

Enrico R. Barrozo, Marcus A. Garcia, Michael D. Jochum, Eliane El Hayek, Eliseo F. Castillo , et al. · 2024

939 Stages of HPV Cervical Cancer Discerned by Integrated Host-viral Single-cell and Spatial Biology Open

Khanh L. Tran, David N. Moorshead, Maryshe Zeitsman, Michael D. Jochum, Kjersti M. Aagaard , et al. · 2024

817 Trans-placental transport of a novel fluorescent lipid nanoparticle in a pre-clinical fetal therapy murine model Open

Maryshe S. Zietsman, Matthew A. Shanahan, Enrico R. Barrozo, Maxim D. Seferovic, Rohan Bhavane , et al. · 2024

Gestational ozone inhalation elicits maternal cardiac dysfunction and transcriptional changes to placental pericytes and endothelial cells Open

Russell Hunter, Brenna Baird, Marcus Garcia, Jessica Begay, Siem Goitom , et al. · 2023

Ozone (O3) is a criteria air pollutant with the most frequent incidence of exceeding air quality standards. Inhalation of O3 is known to cause lung inflammation and consequent systemic health effects, including endothelial dysfunction. Epi…

Zika virus co-opts microRNA networks to persist in placental niches detected by spatial transcriptomics Open

Enrico R. Barrozo, Maxim D. Seferovic, Mark Hamilton, David N. Moorshead, Michael D. Jochum , et al. · 2023

SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics Open

Enrico R. Barrozo, Maxim D. Seferovic, Eumenia Castro, Angela M. Major, David N. Moorshead , et al. · 2023

Viral single-cell transcriptomics reveals distinct SARS-CoV-2 and RSV immune profiles in infants Open

Enrico R. Barrozo, Maxim D. Seferovic, Kyungmin Ko, Megan H. Amerson-Brown, Lara Shekerdemian , et al. · 2023

COVID-19 Pandemic and Infant Neurodevelopmental Impairment Open

Kamran Hessami, Amir Hossein Norooznezhad, Sónia Monteiro, Enrico R. Barrozo, Abolfazl Shirdel Abdolmaleki , et al. · 2022

Importance Primary studies proposed that aberrant maternal antiviral immunity and/or giving birth in quarantine, such as during the ongoing COVID-19 pandemic, may be associated with the risk of neurodevelopmental impairment (NDI) in offspr…

The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms Open

Kimberly Walker, Divya Kalra, Rebecca F. Lowdon, Guangyi Chen, David Molik , et al. · 2022

In October 2021, 59 scientists from 14 countries and 13 U.S. states collaborated virtually in the Third Annual Baylor College of Medicine & DNANexus Structural Variation hackathon. The goal of the hackathon was to advance research on struc…

Placental histopathologic findings from pregnancies diagnosed with COVID-19: A systematic review and meta-analysis Open

Kamran Hessami, Kjersti M. Aagaard, Eumênia Costa da Cunha Castro, Sara E. Arian, Enrico R. Barrozo , et al. · 2021

Human placental biology at single‐cell resolution: a contemporaneous review Open

Enrico R. Barrozo, KM Aagaard · 2021

Single‐cell technologies capture cellular heterogeneity to focus on previously poorly described subpopulations of cells. Work by our laboratory and many others has metagenomically characterised a low biomass intrauterine microbial communit…

Herpes Simplex Virus 1 MicroRNA miR-H8 Is Dispensable for Latency and Reactivation <i>In Vivo</i> Open

Enrico R. Barrozo, Sanae Nakayama, Pankaj Singh, Donna M. Neumann, David C. Bloom · 2020

Herpesviruses have a remarkable ability to sustain lifelong infections by evading host immune responses, establishing a latent reservoir, and maintaining the ability to reactivate the lytic cascade to transmit the virus to the next host. T…

Deletion of Herpes Simplex Virus 1 MicroRNAs miR-H1 and miR-H6 Impairs Reactivation Open

Enrico R. Barrozo, Sanae Nakayama, Pankaj Singh, Emilia A. H. Vanni, Ann M. Arvin , et al. · 2020

While HSV antivirals reduce the severity and duration of clinical disease in some individuals, there is no vaccine or cure. Therefore, understanding the mechanisms regulating latency and reactivation as a potential to elucidate targets for…

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