Explanipedia

Periodic and Aperiodic Alterations of Resting‐State EEG in Schizophrenia Spectrum Disorders: Cognitive and Clinical Insights Open

Genc Hasanaj, Iris Jaeger, Berkhan Karslı, Enrico Schulz, Emanuel Boudriot , et al. · 2025

Schizophrenia spectrum disorders (SSD) are marked by cognitive deficits and clinical symptoms linked to disrupted neural oscillations. While changes in spectral power are well documented in SSD, many studies have not clearly separated rhyt…

Modulating Brain Perfusion, Functional Connectivity, and Metabolite Patterns through Theta Burst Transcranial Ultrasonic Stimulation Open

Daniel Keeser, Lukas Roell, Veronica Meedt, Maximilian Hasslberger, Maxim Korman , et al. · 2025

Background Transcranial ultrasonic stimulation (TUS) is an emerging non-invasive neuromodulation technique with the potential to target both cortical and subcortical brain regions. This study investigates the effects of theta-burst TUS (tb…

Individual variability in cortical representations of tonic pain Open

Bettina Deak, Anne Stankewitz, Astrid Mayr, Viktor Witkovský, Pauline Jahn , et al. · 2025

When people experience pain in everyday situations, the experience is often long-lasting and fluctuating. However, pain research predominantly focuses on artificial brief and repeated singular painful events. Here, we aimed to approximate …

Denoising Strategies of Functional Connectivity MRI Data in Lesional and Non-Lesional Brain Diseases Open

Stephan Wunderlich, Cagatay Alici, Saeed Motevallia, Veit M. Stoecklein, Louisa von Baumgarten , et al. · 2025

Purpose Functional connectivity magnetic resonance imaging (fcMRI) is a widely utilized tool for analyzing functional connectivity (FC) in both healthy and diseased brains. However, patients with brain disorders are particularly susceptibl…

Denoising strategies of functional connectivity MRI data in lesional and non-lesional brain diseases Open

Stephan Wunderlich, Cagatay Alici, Saeed Motevalli, Veit M. Stoecklein, Louisa von Baumgarten , et al. · 2025

Functional connectivity magnetic resonance imaging (fcMRI) is a widely utilized tool for analyzing functional connectivity (FC) in both healthy and diseased brains. However, patients with brain disorders are particularly susceptible to hea…

Brain connectivity in individuals with migraine resets during the headache phase: a whole-brain connectivity study Open

Enrico Schulz, Astrid Mayr, Pauline Jahn, Anne Stankewitz · 2024

Episodic migraine is reflected by cyclic changes in behavior and cortical processing. We aimed to identify how functional connectivity changes over the entire migraine cycle. By using longitudinal neuroimaging and a whole-brain connectivit…

Preserved prenatal lung growth assessed by fetal MRI in the omicron-dominated phase of the SARS-CoV-2 pandemic Open

Gloria Biechele, Vanessa Koliogiannis, Philippe Rennollet, Tobias Prester, Enrico Schulz , et al. · 2024

Interindividual variability and individual stability of pain- and touch-related neuronal gamma oscillations Open

Elia Valentini, Alina Shindy, Viktor Witkovský, Anne Stankewitz, Enrico Schulz · 2023

The interpretation of gamma activity in response to noxious and innocuous somatosensory stimuli has sparked controversy. Here, we show that participants’ gamma oscillations measured through electroencephalography vary. Although some partic…

Preserved Prenatal Lung Growth in Fetal MRI Following Mild Omicron Infection During Pregnancy Open

Gloria Biechele, Vanessa Koliogiannis, Philippe Rennollet, Tobias Prester, Enrico Schulz , et al. · 2023

Investigation on how dynamic effective connectivity patterns encode the fluctuating pain intensity in chronic migraine Open

Iege Bassez, Frederik Van de Steen, Sophie Hackl, Pauline Jahn, Astrid Mayr , et al. · 2022

Chronic migraine is characterised by persistent headaches for >15 days per month; the intensity of the pain is fluctuating over time. Here, we explored the dynamic interplay of connectivity patterns between regions known to be related to p…

Investigation on How Dynamic Effective Connectivity Patterns Encode the Fluctuating Pain Intensity in Chronic Migraine Open

Iege Bassez, Frederik Van de Steen, Sophie Hackl, Pauline Jahn, Astrid Mayr , et al. · 2022

Chronic migraine is characterised by persistent headaches for more than 15 days per month; the intensity of the pain is fluctuating over time. Here, we explored the dynamic interplay of connectivity patterns between regions known to be rel…

Intrinsic network connectivity reflects the cyclic trajectory of migraine attacks Open

Anne Stankewitz, Enrico Schulz · 2022

Individual Stability of Pain- and Touch-Related Neuronal Gamma Oscillations Open

Elia Valentini, Alina Shindy, Viktor Witkovský, Anne Stankewitz, Enrico Schulz · 2021

Background The processing of brief pain and touch stimuli has been associated with an increase of neuronal oscillations in the gamma range (40-90 Hz). However, some studies report divergent gamma effects across single participants. Methods…

Increased Functional Connectivity Characterises the Prodromal Phase of the Migraine Cycle Open

Anne Stankewitz, Astrid Mayr, Enrico Schulz · 2021

Introduction Episodic migraine is reflected by cyclic changes in behaviour and cortical processing. We aimed to identify how Functional connectivities change over the entire migraine cycle. Methods By using longitudinal neuroimaging and a …

Intrinsic Network Activity Reflects the Ongoing Experience of Chronic Pain Open

Pauline Jahn, Bettina Deak, Astrid Mayr, Anne Stankewitz, Daniel Keeser , et al. · 2021

Analyses of intrinsic network activity have been instrumental in revealing cortical processes that are altered in chronic pain patients. However, such studies have not accounted for variable time courses of network activity and subjective …

Intrinsic Network Connectivity Reflects the Cyclic Trajectory of Migraine Attacks Open

Anne Stankewitz, Enrico Schulz · 2021

Background Episodic migraine is considered to be cyclic in nature, triggered by the hypothalamus. To assess the natural trajectory of intrinsic networks over an entire migraine cycle, we designed a longitudinal intra-individual study using…

Intrinsic Network Activity Reflects the Fluctuating Experience of Tonic Pain Open

Bettina Deak, Thomas Eggert, Astrid Mayr, Anne Stankewitz, Filipp Filippopulos , et al. · 2021

Although we know sensation is continuous, research on long-lasting and continuously changing stimuli is scarce and the dynamic nature of ongoing cortical processing is largely neglected. In a longitudinal study with 152 fMRI sessions, part…

Individually Unique Dynamics of Cortical Connectivity Reflect the Ongoing Intensity of Chronic Pain Open

Astrid Mayr, Pauline Jahn, Bettina Deak, Anne Stankewitz, Vasudev Devulapally , et al. · 2021

Background Chronic pain diseases are characterised by an ongoing and fluctuating endogenous pain, yet it remains to be elucidated how this is reflected by the dynamics of ongoing functional cortical connections. The present study addresses…

Pain and the Emotional Brain: Affective Rather than Cognitive Processes Drive the Cortical Encoding of Pain Open

Anne Stankewitz, Astrid Mayr, Stephanie Irving, Viktor Witkovský, Enrico Schulz · 2021

Background The experience of pain has been dissociated into two interwoven aspects: a sensory-discriminative aspect and an affective-motivational aspect. We aimed to explore which of the pain descriptors is more deeply rooted in the human …

A Novel Tool for the Removal of Muscle Artefacts from EEG: Improving Data Quality in the Gamma Frequency Range Open

Alina Pauline Liebisch, Thomas Eggert, Alina Shindy, Elia Valentini, Stephanie Irving , et al. · 2020

Background The past two decades have seen a particular focus towards high-frequency neural activity in the gamma band (>30Hz). However, gamma band activity shares frequency range with unwanted artefacts from muscular activity. New Method W…

Migraine Attacks as a Result of Hypothalamic Loss of Control Open

Anne Stankewitz, Leonie Keidel, Mathias Rehm, Stephanie Irving, Stephan Kaczmarz , et al. · 2020

To assess the natural trajectory of brain activity over the migraine cycle, we assessed (1) the cerebral perfusion and (2) the hypothalamic connectivity during spontaneous headache attacks with follow-up recordings towards the next migrain…

Visual word form processing deficits driven by severity of reading impairments in children with developmental dyslexia Open

Silvia Brem, Urs Maurer, Martin Kronbichler, Matthias Schurz, Fabio Richlan , et al. · 2020

Decision letter: The temporal and spectral characteristics of expectations and prediction errors in pain and thermoception Open

Enrico Schulz · 2020

Chronic Pain Patients Exhibit Individually Unique Cortical Signatures of Pain Open

Astrid Mayr, Pauline Jahn, Anne Stankewitz, Bettina Deak, Anderson M. Winkler , et al. · 2020

We investigated how the trajectory of pain patients’ ongoing and fluctuating pain is encoded in the brain. In repeated fMRI sessions, 20 chronic back pain patients and 20 chronic migraineurs were asked to continuously rate the intensity of…

Author response: Ultra-high-field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain Open

Enrico Schulz, Anne Stankewitz, Anderson M. Winkler, Stephanie Irving, Viktor Witkovský , et al. · 2020

Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract We investigated how the attenuation of pai…

Ultra-high field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain Open

Enrico Schulz, Anne Stankewitz, Anderson M. Winkler, Stephanie Irving, Viktor Witkovský , et al. · 2019

We investigate how the attenuation of pain with cognitive interventions affects the strength of cortical connections by pursuing a whole brain approach. While receiving tonic cold pain, 20 healthy participants were asked to utilise three d…

Neuronal Oscillations in Various Frequency Bands Differ between Pain and Touch Open

Georgios Michail, Christian Dresel, Viktor Witkovský, Anne Stankewitz, Enrico Schulz · 2016

Although humans are generally capable of distinguishing single events of pain or touch, recent research suggested that both modalities activate a network of similar brain regions. By contrast, less attention has been paid to which processe…

Prefrontal Gamma Oscillations Encode Tonic Pain in Humans Open

Enrico Schulz, Elisabeth S. May, Martina Postorino, Laura Tiemann, Moritz M. Nickel , et al. · 2015

Under physiological conditions, momentary pain serves vital protective functions. Ongoing pain in chronic pain states, on the other hand, is a pathological condition that causes widespread suffering and whose treatment remains unsatisfacto…

Emotion regulation and depression correlate with structural differences in patients six months after lumbar disc surgery Open

Omar Chehadi, Adina C. Rusu, Enrico Schulz, Monika Hasenbring · 2015

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