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View article: Evaluation of a Targeted Next-generation Sequencing Assay for <i>BRCA</i> Mutation Screening in Clinical Samples
Evaluation of a Targeted Next-generation Sequencing Assay for <i>BRCA</i> Mutation Screening in Clinical Samples Open
cancers in 2018 in the United States [1].Every year, approximately 20,000 new cases of breast and ovarian cancers are detected in South Korea [2, 3].The genetically well-characterized risk factors of breast and/or ovarian cancers include g…
View article: Molecular changes in solitary fibrous tumor progression
Molecular changes in solitary fibrous tumor progression Open
Solitary fibrous tumors (SFTs) are NAB2-STAT6 fusion-associated neoplasms. There are several subtypes of NAB2-STAT6 fusions, but their clinical significances are still unclear. Moreover, the mechanisms of malignant progression are also poo…
View article: Engrailed 1 overexpression as a potential prognostic marker in quintuple-negative breast cancer
Engrailed 1 overexpression as a potential prognostic marker in quintuple-negative breast cancer Open
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype characterized by poor patient prognosis and for which no targeted therapies are currently available. TNBC can be further categorized as either basal-like (BLBC) or…
View article: Unforeseen clonal evolution of tumor cell population in recurrent and metastatic dermatofibrosarcoma protuberans
Unforeseen clonal evolution of tumor cell population in recurrent and metastatic dermatofibrosarcoma protuberans Open
Dermatofibrosarcoma protuberans (DFSP) is a very rare soft tissue sarcoma, generally of low-grade malignancy. DFSP is locally aggressive with a high recurrence rate, but metastasis occurs rarely. To investigate the mechanism of metastasis …
View article: Genes co-amplified with <i>ERBB2</i> or <i>MET</i> as novel potential cancer-promoting genes in gastric cancer
Genes co-amplified with <i>ERBB2</i> or <i>MET</i> as novel potential cancer-promoting genes in gastric cancer Open
Gastric cancer (GC), one of the most common cancers worldwide, has a high mortality rate due to limited treatment options. Identifying novel and promising molecular targets is a major challenge that must be overcome if treatment of advance…
View article: Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients
Targeted exome sequencing of Korean triple-negative breast cancer reveals homozygous deletions associated with poor prognosis of adjuvant chemotherapy-treated patients Open
Triple-negative breast cancer is characterized by the absence of estrogen and progesterone receptors and human epidermal growth factor receptor 2, and is associated with a poorer outcome than other subtypes of breast cancer. Moreover, ther…
View article: LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients
LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients Open
Therapies targeting SRC family kinases (SFKs) have shown efficacy in treating non-small cell lung cancer (NSCLC). However, recent clinical trials have found that the SFK inhibitor dasatinib is ineffective in some patient cohorts. Regardles…
View article: Efficiency of Methylated DNA Immunoprecipitation Bisulphite Sequencing for Whole-Genome DNA Methylation Analysis
Efficiency of Methylated DNA Immunoprecipitation Bisulphite Sequencing for Whole-Genome DNA Methylation Analysis Open
MeDIP-BS is a practical cost-effective method for analyzing whole-genome DNA methylation that is highly accurate at base-pair resolution.
View article: Chronic TGFβ stimulation promotes the metastatic potential of lung cancer cells by Snail protein stabilization through integrin β3-Akt-GSK3β signaling
Chronic TGFβ stimulation promotes the metastatic potential of lung cancer cells by Snail protein stabilization through integrin β3-Akt-GSK3β signaling Open
Chronic exposure to TGFβ, a frequent occurrence for tumor cells in the tumor microenvironment, confers more aggressive phenotypes on cancer cells by promoting their invasion and migration while at the same time increasing their resistance …
View article: Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma
Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma Open
Malignant pheochromocytoma/paraganglioma (PCC/PGL) is defined by the presence of metastases at non-chromaffin sites, which makes it difficult to prospectively diagnose malignancy. Here, we performed array CGH (aCGH) and paired gene express…
View article: Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples
Comparison of Accuracy of Whole-Exome Sequencing with Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tissue Samples Open
Formalin fixing with paraffin embedding (FFPE) has been a standard sample preparation method for decades, and archival FFPE samples are still very useful resources. Nonetheless, the use of FFPE samples in cancer genome analysis using next-…
View article: GalNAc-T14 promotes metastasis through Wnt dependent<i>HOXB9</i>expression in lung adenocarcinoma
GalNAc-T14 promotes metastasis through Wnt dependent<i>HOXB9</i>expression in lung adenocarcinoma Open
While metastasis, the main cause of lung cancer-related death, has been extensively studied, the underlying molecular mechanism remains unclear. A previous clinicogenomic study revealed that expression of N-acetylgalactosaminyltransferase …
View article: HER2 as a novel therapeutic target for cervical cancer
HER2 as a novel therapeutic target for cervical cancer Open
Surgery and radiation are the current standard treatments for cervical cancer. However, there is no effective therapy for metastatic or recurrent cases, necessitating the identification of therapeutic targets. In order to create preclinica…