Entao Li
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View article: High-Update-Rate (25 kHz) Laser Ranging with Random Noise Modulation for Fast and Precise Absolute Distance Measurement
High-Update-Rate (25 kHz) Laser Ranging with Random Noise Modulation for Fast and Precise Absolute Distance Measurement Open
This paper proposes a technique for precise distance measurement under laser random noise using autocorrelation demodulation. We conducted measurements within a 2 m range using a commercial digitizer with a sampling rate of 40 GS/s. The si…
View article: Polyethyleneimine-modified Laminarin nanoparticles enhance antigen delivery to lymph nodes by inducing transient inflammatory responses at the injection site
Polyethyleneimine-modified Laminarin nanoparticles enhance antigen delivery to lymph nodes by inducing transient inflammatory responses at the injection site Open
Functionalized nanoparticles hold great potential as vaccine adjuvants. In our previous study, we demonstrated that polyethyleneimine-modified Laminarin nanoparticles (CLam/OVA) exhibit potent adjuvant effects. However, it is still unclear…
View article: Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein
Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein Open
Hendra and Nipah viruses (HNVs), zoonotic paramyxoviruses with >50% case fatality rates, cause fatal encephalitis and respiratory disease, yet lack approved therapies. Here, nine rhesus‐derived monoclonal antibodies (mAbs) targeting the fu…
View article: Generation of nanobodies against the F protein of respiratory syncytial virus and establishment of an indirect immunofluorescence assay
Generation of nanobodies against the F protein of respiratory syncytial virus and establishment of an indirect immunofluorescence assay Open
Respiratory syncytial virus (RSV) infection is a leading cause of acute respiratory infections and death in children and older adults. Currently, there is a lack of effective vaccines and antibody treatments on the market, and the clinical…
View article: An mpox quadrivalent mRNA vaccine elicits sustained and protective immunity in mice against lethal vaccinia virus challenge
An mpox quadrivalent mRNA vaccine elicits sustained and protective immunity in mice against lethal vaccinia virus challenge Open
Assessing the long-term efficacy of MPXV vaccine candidates is crucial for the global response to the ongoing mpox epidemic. Built upon our previous study of the mpox quadrivalent mRNA vaccine, herein we reported that MPXV-1103 could elici…
View article: Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants
Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants Open
Booster vaccinations are highly recommended in combating the SARS-CoV-2 Omicron variant and its subvariants. However, the optimal booster vaccination strategies and related immune mechanisms with different prior vaccinations are under-reve…
View article: Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters
Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mice and hamsters Open
Nipah virus (NiV) is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia. NiV leads to severe respiratory disease and encephalitis in humans and animals, with a mortality rate of up to 75%. Despite the gra…
View article: Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control
Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control Open
To adequately prepare for potential hazards caused by emerging and reemerging infectious diseases, the WHO has issued a list of high-priority pathogens that are likely to cause future outbreaks and for which research and development (R&D) …
View article: A novel circular Delta-XBB.1.5 RBD dimeric protein subunit vaccine mediated by split intein elicits an immune response and protection against multiple SARS-CoV-2 variants in mice
A novel circular Delta-XBB.1.5 RBD dimeric protein subunit vaccine mediated by split intein elicits an immune response and protection against multiple SARS-CoV-2 variants in mice Open
SARS-CoV-2 continues to mutate, leading to breakthrough infections. The development of new vaccine strategies to combat variant strains is crucial. Protein cyclization can enhance thermal stability and may improve immunogenicity. Here, we …
View article: Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus
Polyvalent mpox mRNA vaccines elicit robust immune responses and confer potent protection against vaccinia virus Open
The 2022 mpox outbreak led the World Health Organization (WHO) to declare it a public health emergency of international concern (PHEIC). There is a need to develop more effective and safer mpox virus (MPXV)-specific vaccines in response to…
View article: A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice
A live attenuated influenza B virus vaccine expressing RBD elicits protective immunity against SARS-CoV-2 in mice Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant threat to human health globally. It is crucial to develop a vaccine to reduce the effect of the virus on public health, economy, and society and regulate the …
View article: Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice
Circular RNA vaccines against monkeypox virus provide potent protection against vaccinia virus infection in mice Open
Since the outbreak of monkeypox (mpox) in 2022, widespread concern has been placed on imposing an urgent demand for specific vaccines that offer safer and more effective protection. Using an efficient and scalable circular RNA (circRNA) pl…
View article: The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association
The PKA-CREB1 axis regulates coronavirus proliferation by viral helicase nsp13 association Open
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a worldwide threat in the past 3 years. Although it has been widely and intensively investigated, the mechanism underlying the coronavir…
View article: A mpox quadrivalent mRNA vaccine protects mice from a lethal vaccinia virus challenge
A mpox quadrivalent mRNA vaccine protects mice from a lethal vaccinia virus challenge Open
The outbreak of 2022 mpox virus (MPXV) infection in nonendemic regions is a global public health concern. A highly effective and safe MPXV vaccine that is available to the general public is urgently needed to control the MPXV pandemic. Her…
View article: Long‐term immune response to Omicron‐specific mRNA vaccination in mice, hamsters, and nonhuman primates
Long‐term immune response to Omicron‐specific mRNA vaccination in mice, hamsters, and nonhuman primates Open
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron and its subvariants (such as BQ.1, XBB and the latest variants, including XBB.1.16, EG.5, and BA.2.86), as the dominant variants, currently account for almost all new inf…
View article: Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection Open
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity and the lack of viable countermeasures. Vaccines are the most crucial defense against NiV infections. Here, a recomb…
View article: Vaccines based on the fusion protein consensus sequence protect Syrian hamsters from Nipah virus infection
Vaccines based on the fusion protein consensus sequence protect Syrian hamsters from Nipah virus infection Open
Nipah virus (NiV), a bat-borne paramyxovirus, results in neurological and respiratory diseases with high mortality in humans and animals. Developing vaccines is crucial for fighting these diseases. Previously, only a few studies focused on…
View article: Ebola virus VP35 perturbs type I interferon signaling to facilitate viral replication
Ebola virus VP35 perturbs type I interferon signaling to facilitate viral replication Open
As one of the deadliest viruses, Ebola virus (EBOV) causes lethal hemorrhagic fevers in humans and nonhuman primates. The suppression of innate immunity leads to robust systemic virus replication of EBOV, leading to enhanced transmission. …
View article: Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus
Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus Open
The ongoing pandemic caused by mpox virus (MPXV) has become an international public health emergency that poses a significant threat to global health. The vaccinia virus Tiantan strain (VTT) was used to vaccinate against smallpox in China …
View article: An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1&2 and most variants
An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1&2 and most variants Open
SARS-CoV-2, a type of respiratory virus, has exerted a great impact on global health and economy over the past three years. Antibody-based therapy was initially successful but later failed due to the accumulation of mutations in the spike …
View article: Therapeutic equine hyperimmune antibodies with high and broad-spectrum neutralizing activity protect rodents against SARS-CoV-2 infection
Therapeutic equine hyperimmune antibodies with high and broad-spectrum neutralizing activity protect rodents against SARS-CoV-2 infection Open
The emergence of SARS-CoV-2 variants stresses the continued need for broad-spectrum therapeutic antibodies. Several therapeutic monoclonal antibodies or cocktails have been introduced for clinical use. However, unremitting emerging SARS-Co…
View article: Bacillus subtilis vector based oral rabies vaccines induced potent immune response and protective efficacy in mice
Bacillus subtilis vector based oral rabies vaccines induced potent immune response and protective efficacy in mice Open
Introduction Rabies is a worldwide epidemic that poses a serious threat to global public health. At present, rabies in domestic dogs, cats, and some pets can be effectively prevented and controlled by intramuscular injection of rabies vacc…