Explanipedia

Transcriptomic Differences Between Human Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells Reveal Specific Biomarker Profiles Open

Rong Du, Ajay Kumar, Enzhi Yang, Jingxue Zhang, Ningli Wang , et al. · 2025

Glaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause. Trabecular meshwork stem cells (TMSCs) have emerged as promising candidates …

Identification and Validation of Key Biomarkers in the Proximal Aqueous Humor Outflow Pathway Open

Rong Du, Enzhi Yang, Madison Clark, Ningli Wang, Yiqin Du · 2025

Glaucoma is a leading cause of irreversible blindness, with elevated intraocular pressure (IOP) as the most important risk factor. The trabecular meshwork (TM) and Schlemm’s canal are the main components of the proximal aqueous humor outfl…

Stem Cell Secretome Promotes Scarless Corneal Wound Healing and Rescues Corneal Sensory Nerves Open

Ajay Kumar, Yunshu Li, S. Mallick, Enzhi Yang, Deepinder K. Dhaliwal , et al. · 2022

Corneal scarring is a leading cause of blindness in the world. In this study, we explored the therapeutic potential of corneal stromal stem cell (CSSC)-derived secretome in a mechanical debridement mouse model of corneal scarring. CSSC sec…

Stem cell-free therapy for glaucoma to preserve vision Open

Ajay Kumar, Siqi Xiong, Minwen Zhou, Wen Chen, Enzhi Yang , et al. · 2021

Glaucoma is the leading cause of irreversible blindness with trabecular meshwork (TM) dysfunction resulting in elevated intraocular pressure and retinal ganglion cell (RGC) damage leading to vision loss. In this study, we discovered that s…

Author response: Stem cell transplantation rescued a primary open-angle glaucoma mouse model Open

Siqi Xiong, Ajay Kumar, Shenghe Tian, Eman E. Taher, Enzhi Yang , et al. · 2021

Stem Cell Transplantation Rescued A Primary Open-Angle Glaucoma Mouse Model Open

Siqi Xiong, Ajay Kumar, Shenghe Tian, Eman E. Taher, Enzhi Yang , et al. · 2020

Glaucoma is a leading cause of irreversible blindness. In this study, we investigated if exogenous stem cells are able to rescue a glaucoma mouse model with transgenic myocilin Y437H mutation and explored the possible mechanisms. Human tra…

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway Open

Yiwen Wang, Deborah Osakue, Enzhi Yang, Yi Zhou, Haiyan Gong , et al. · 2019

In response to ER stress inducers, TMSCs activated a lower level of UPR and lasted shorter than TM cells. Inhibition of elF2α dephosphorylation had a protective mechanism against cell death. Stem cells combined with salubrinal may be a mor…

Stemness and Regenerative Potential of Corneal Stromal Stem Cells and Their Secretome After Long-Term Storage: Implications for Ocular Regeneration Open

Ajay Kumar, Yi Xu, Enzhi Yang, Yiqin Du · 2018

CSSCs maintained their stemness and multipotency after long-term storage, and secretome derived from these cells can be of paramount importance for corneal regeneration and prevention of fibrosis.

Possible Autologous Stem Cell Resources for Trabecular Meshwork Regeneration Open

Enzhi Yang, Ajay Kumar, Yiqin Du · 2018

Morphologic Changes in Trabecular Meshwork Associated with Thapsigargin Induced Mouse Glaucoma Model Open

Ruiyi Ren, Yi Zhou, Thuy Duong Le, Enzhi Yang, Yiqin Du , et al. · 2017

Mechanisms of Stem Cell Homing for Trabecular Meshwork Regeneration Open

Yiqin Du, Yi Zhou, Hongmin Yun, Enzhi Yang · 2017

A Mouse Model for Cell Therapy on Trabecular Meshwork Regeneration Open

Enzhi Yang, Yi Zhou, Hongmin Yun, Yiqin Du · 2016

Human Adipose-derived Stem Cells Integrate into Normal Mouse Trabecular Meshwork Open

Yi Zhou, Hongmin Yun, Enzhi Yang, Xiaobo Xia, Joel S. Schuman , et al. · 2016

Trabecular Meshwork Regeneration by Stem Cells Open

Yiqin Du, Hongmin Yun, Yi Zhou, Enzhi Yang · 2016

IOP elevation after laser treatment. Open

Yun Hong-min, Lathrop Kira L., Enzhi Yang, Ming Sun, Kagemann Larry , et al. · 2015

IOP of laser treated and fellow untreated eyes was shown at different time points after laser. Values are mean ±SEM. Dashed line represents the 99.5th percentile of normal IOP range as shown in Table 1. The difference between two groups at…

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