Explanipedia

Reconstitution of adrenocortical functional zonation from human pluripotent stem cells Open

Michinori Mayama, Eoin C. Whelan, Takeshi Sato, David G. Stouffer, Adrian N. Leu , et al. · 2025

Summary The adrenal cortex produces essential steroid hormones through a concentric zonal architecture, established by the centripetal trans-differentiation of subcapsular progenitors within a capsule-derived niche. To capture this complex…

Single-cell multiomic comparison of mouse and rat spermatogenesis reveals gene regulatory networks conserved for over 20 million years Open

Eoin C. Whelan, J. E. Swain, Jonathan Sussman, David Smith, Fan Yang , et al. · 2025

Defining the cellular origin of seminoma by transcriptional and epigenetic mapping to the normal human germline Open

Keren Cheng, Yasunari Seita, Eoin C. Whelan, Ryo Yokomizo, Young Sun Hwang , et al. · 2024

Aberrant male germline development can lead to the formation of seminoma, a testicular germ cell tumor. Seminomas are biologically similar to primordial germ cells (PGCs) and many bear an isochromosome 12p [i(12p)] with two additional copi…

Transcriptional control of the Cryptosporidium life cycle Open

Katelyn A. Walzer, Jayesh Tandel, Jessica H. Byerly, A Daniels, Jodi A. Gullicksrud , et al. · 2024

Generation of spermatogonia from pluripotent stem cells in humans and non-human primates Open

Eoin C. Whelan, Young Sun Hwang, Yasunari Seita, Ryo Yokomizo, N. Adrian Leu , et al. · 2024

Failures in germline development drive male infertility, but the lack of model systems that recapitulate human spermatogenesis hampers therapeutic development. Here, we have developed a system to differentiate human induced pluripotent ste…

Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients Open

Antonia Rotolo, Eoin C. Whelan, Matthew J. Atherton, Irina Kulikovskaya, Danuta Jarocha , et al. · 2023

Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity Open

Eoin C. Whelan, Fan Yang, Mary R. Avarbock, Megan C. Sullivan, Daniel P. Beiting , et al. · 2022

Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys is to cryopreserve a testicular bi…

Roles of<i>Stra8</i>and<i>Tcerg1l</i>in retinoic acid induced spermatogonial differentiation in mouse Open

Nilam Sinha, Eoin C. Whelan, John W. Tobias, Mary R. Avarbock, Darko Stefanovski , et al. · 2021

Retinoic acid (RA) induces spermatogonial differentiation, but the mechanism by which it operates remains largely unknown. We developed a germ cell culture assay system to study genes involved in spermatogonial differentiation triggered by…

FGF9 promotes mouse spermatogonial stem cell proliferation mediated by p38 MAPK signalling Open

Fan Yang, Eoin C. Whelan, Xuebing Guan, Bingquan Deng, Shu Wang , et al. · 2020

Objectives Fibroblast growth factor 9 (FGF9) is expressed by somatic cells in the seminiferous tubules, yet little information exists about its role in regulating spermatogonial stem cells (SSCs). Materials and Methods Fgf9 overexpression …

Selective mutation accumulation: a computational model of the paternal age effect Open

Eoin C. Whelan, Alexander C. Nwala, Christopher Osgood, Stephan Olariu · 2016

Motivation: As the mean age of parenthood grows, the effect of parental age on genetic disease and child health becomes ever more important. A number of autosomal dominant disorders show a dramatic paternal age effect due to selfish mutati…

Selfish Mutations: the Genetic Basis of the Paternal Age Effect Open

Eoin C. Whelan · 2016

As the mean age of childrearing grows, the effect of parental age on genetic disease and child health becomes ever more important. A number of autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: subst…

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