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View article: Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis
Radiological correlates of pseudobulbar affect: Corticobulbar and cerebellar components in primary lateral sclerosis Open
View article: Editorial: Genotype–phenotype correlations in neurodegenerative diseases: From clinical features to neuroimaging signatures
Editorial: Genotype–phenotype correlations in neurodegenerative diseases: From clinical features to neuroimaging signatures Open
EDITORIAL article Front. Neurol., 16 December 2022Sec. Applied Neuroimaging Volume 13 - 2022 | https://doi.org/10.3389/fneur.2022.1100953
View article: Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs
Propagation patterns in motor neuron diseases: Individual and phenotype-associated disease-burden trajectories across the UMN-LMN spectrum of MNDs Open
Motor neuron diseases encompass a divergent group of conditions with considerable differences in clinical manifestations, survival, and genetic vulnerability. One of the key aspects of clinical heterogeneity is the preferential involvement…
View article: The evolution of cortical integrity in motor neuron diseases: longitudinal cortical thickness profiles in ALS, PLS and poliomyelitis
The evolution of cortical integrity in motor neuron diseases: longitudinal cortical thickness profiles in ALS, PLS and poliomyelitis Open
Corresponding author: Peter Bede, Computational Neuroimaging Group, Trinity Biomedical Sciences Institute, Trinity College Dublin; email: [email protected] Abstract One of the central aspects of clinical heterogeneity in motor neuron diseases i…
View article: Preface: promoting research in PLS: current knowledge and future challenges
Preface: promoting research in PLS: current knowledge and future challenges Open
"Preface: promoting research in PLS: current knowledge and future challenges." Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21(sup1), pp. 1–2
View article: Imaging and clinical data indicate considerable disease burden in ‘probable’ PLS: Patients with UMN symptoms for 2–4 years
Imaging and clinical data indicate considerable disease burden in ‘probable’ PLS: Patients with UMN symptoms for 2–4 years Open
Primary lateral sclerosis (PLS) is an adult-onset upper motor neuron disease manifesting in progressive spasticity and gradually resulting in considerably motor disability. In the absence of early disease-specific diagnostic indicators, th…
View article: MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis
MRI data confirm the selective involvement of thalamic and amygdalar nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis Open
View article: The imaging profile of “probable PLS”: white and grey matter measures
The imaging profile of “probable PLS”: white and grey matter measures Open
The recent consensus criteria for the diagnosis of primary lateral sclerosis (PLS) introduced the category of “probable PLS” for patients exhibiting upper-motor-neuron sings with a symptom duration interval of 2-4 years. These patients wou…
View article: Thalamic nuclei in motor neuron disease: volumetric profiles
Thalamic nuclei in motor neuron disease: volumetric profiles Open
Thalamic degeneration is a recognised feature of motor neuron disease which manifest in a range of extrapyramidal motor and neuropsychological deficits. While computational neuroimaging allows the detailed characterisation of thalamic chan…
View article: A Bayesian segmentation of the amygdala in ALS and PLS: volumetric data
A Bayesian segmentation of the amygdala in ALS and PLS: volumetric data Open
Temporal lobe degeneration is a recognised feature of motor neuron disease which may manifest in a range of cognitive deficits contributing to the clinical heterogeneity of the condition. Computational neuroimaging allows the detailed char…
View article: Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of “probable PLS”
Evolving diagnostic criteria in primary lateral sclerosis: The clinical and radiological basis of “probable PLS” Open
View article: “Switchboard” malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis
“Switchboard” malfunction in motor neuron diseases: Selective pathology of thalamic nuclei in amyotrophic lateral sclerosis and primary lateral sclerosis Open
View article: Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease
Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease Open
Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are poorly understood, an…
View article: Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention
Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention Open
Pathological crying and laughing (PCL) has significant quality-of-life implications in amyotrophic lateral sclerosis (ALS); it can provoke restrictive life-style modifications and lead to social isolation. Despite its high prevalence and q…
View article: Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS
Tracking a Fast-Moving Disease: Longitudinal Markers, Monitoring, and Clinical Trial Endpoints in ALS Open
Amyotrophic lateral sclerosis (ALS) encompasses a heterogeneous group of phenotypes with different progression rates, varying degree of extra-motor involvement and divergent progression patterns. The natural history of ALS is increasingly …
View article: Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling
Widespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling Open
PLS is associated with considerable subcortical grey matter degeneration and due to the extensive extra-motor involvement, it should no longer be regarded a pure upper motor neuron disorder. Given its unique pathological features and a cli…
View article: Occulomotor Neural Integrator Dysfunction in Multiple Sclerosis: Insights From Neuroimaging
Occulomotor Neural Integrator Dysfunction in Multiple Sclerosis: Insights From Neuroimaging Open
Background: Magnetic resonance imaging is a key diagnostic and monitoring tool in multiple Sclerosis (MS). While the substrates of motor and neuropsychological symptoms in MS have been extensively investigated, nystagmus-associated …
View article: From Pneumomyelography to Cord Tractography: Historical Perspectives on Spinal imaging
From Pneumomyelography to Cord Tractography: Historical Perspectives on Spinal imaging Open
View article: Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns
Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns Open
This study evaluates disease-associated imaging measures in a dummy diagnostic application. Although larger samples will be required for robust validation, the study confirms the potential of multimodal quantitative imaging in future clini…