Ephrahime S. Traore
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View article: Indole <i>N</i> ‐Linked Hydroperoxyl Adduct of Protein‐Derived Cofactor Modulating Catalase‐Peroxidase Functions
Indole <i>N</i> ‐Linked Hydroperoxyl Adduct of Protein‐Derived Cofactor Modulating Catalase‐Peroxidase Functions Open
Bifunctional catalase‐peroxidase (KatG) features a posttranslational methionine‐tyrosine‐tryptophan (MYW) crosslinked cofactor crucial for its catalase function, enabling pathogens to neutralize hydrogen peroxide during infection. We disco…
View article: Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis
Structural and spectroscopic characterization of RufO indicates a new biological role in rufomycin biosynthesis Open
Rufomycins constitute a class of cyclic heptapeptides isolated from actinomycetes. They are secondary metabolites that show promising treatment against Mycobacterium tuberculosis infections by inhibiting a novel drug target. Several nonpro…
View article: Charge Maintenance during Catalysis in Nonheme Iron Oxygenases
Charge Maintenance during Catalysis in Nonheme Iron Oxygenases Open
Here, the choice of the first coordination shell of the metal center is analyzed from the perspective of charge maintenance in a binary enzyme-substrate complex and an O2-bound ternary complex in the nonheme iron oxygenases. Com…
View article: Heme Binding to HupZ with a C-Terminal Tag from Group A Streptococcus
Heme Binding to HupZ with a C-Terminal Tag from Group A Streptococcus Open
HupZ is an expected heme degrading enzyme in the heme acquisition and utilization pathway in Group A Streptococcus. The isolated HupZ protein containing a C-terminal V5-His6 tag exhibits a weak heme degradation activity. Here, we revisited…