E. R. de Kloet
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View article: The Selective Glucocorticoid Receptor Modulator CORT125329 Decreases Neuroinflammation and Gliosis and Enhances Myelination in the Wobbler Model of Amyotrophic Lateral Sclerosis
The Selective Glucocorticoid Receptor Modulator CORT125329 Decreases Neuroinflammation and Gliosis and Enhances Myelination in the Wobbler Model of Amyotrophic Lateral Sclerosis Open
The Wobbler mouse is a genetic model of familial amyotrophic lateral sclerosis. Wobblers show spinal cord neurodegeneration associated with gliosis, neuroinflammation, and demyelination. Similar to human neurodegenerative diseases, Wobbler…
View article: Edo Ronald de Kloet: How does the action of glucocorticoids change from protective to harmful? What is the cause? And what are the consequences?
Edo Ronald de Kloet: How does the action of glucocorticoids change from protective to harmful? What is the cause? And what are the consequences? Open
For half a century, Edo Ronald (Ron) de Kloet has pursued a fundamental question in neuroscience: how do stress hormones switch from protecting our brain to potentially harming it? After receiving his PhD in 1972 at the University of Utrec…
View article: Glucocorticoid feedback paradox: a homage to Mary Dallman
Glucocorticoid feedback paradox: a homage to Mary Dallman Open
As the end product of the hypothalamus-pituitary-adrenal (HPA) axis, the glucocorticoid hormones cortisol and corticosterone coordinate circadian activities, stress-coping, and adaptation to change. For this purpose, the hormone promotes e…
View article: COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses
COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses Open
Aims It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and to be disproportionally affected by coronavirus disease 19 (COVID-19) once infected. We aimed…
View article: Sleeping off stress
Sleeping off stress Open
Social defeat activates midbrain cells, promoting sleep and reducing anxiety in mice
View article: Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies
Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies Open
Cortisol and corticosterone (CORT) coordinate circadian events and manage the stress response by differential activation of two complementary brain receptor systems, i.e., the mineralocorticoid receptor (MR) and the glucocorticoid receptor…
View article: Prenatal predictors of childhood anxiety disorders: An exploratory study of the role of attachment organization
Prenatal predictors of childhood anxiety disorders: An exploratory study of the role of attachment organization Open
Childhood anxiety disorders (CAD) are a common childhood mental disorder and understanding early developmental pathways is key to prevention and early intervention. What is not understood is whether early life stress predictors of CAD migh…
View article: Faculty Opinions recommendation of Engram-specific transcriptome profiling of contextual memory consolidation.
Faculty Opinions recommendation of Engram-specific transcriptome profiling of contextual memory consolidation. Open
Sparse populations of neurons in the dentate gyrus (DG) of the hippocampus are causally implicated in the encoding of contextual fear memories. However, engram-specific molecular mechanisms underlying memory consolidation remain largely un…
View article: Faculty Opinions recommendation of Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids.
Faculty Opinions recommendation of Local steroid activation is a critical mediator of the anti-inflammatory actions of therapeutic glucocorticoids. Open
OBJECTIVES: The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) plays a well-characterised role in the metabolism and activation of endogenous glucocorticoids (GCs). However, despite its potent upregulation at sites of inflammati…
View article: Forced swim stressor: Trends in usage and mechanistic consideration
Forced swim stressor: Trends in usage and mechanistic consideration Open
The acquired immobility response during the “forced swim test (FST)” is not a rodent model of depression, but the test has some validity in predicting a compound's antidepressant potential. Nevertheless, 60% of the about 600 papers that we…
View article: The Detection of Bornavirus in Birds, Mammals and Snakes by Sandwich ELISA of Bornaviral Matrix Protein
The Detection of Bornavirus in Birds, Mammals and Snakes by Sandwich ELISA of Bornaviral Matrix Protein Open
This study describes a further analysis of the detection of bornaviral antigens by sandwich ELISA. The results show that using chicken anti-psittacine bornaviral P16 matrix protein antibody for capture and rabbit antibody to this protein f…
View article: Faculty Opinions recommendation of Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons.
Faculty Opinions recommendation of Social bonds do not mediate the relationship between early adversity and adult glucocorticoids in wild baboons. Open
In humans and other animals, harsh conditions in early life can have profound effects on adult physiology, including the stress response.This relationship may be mediated by a lack of supportive relationships in adulthood.That is, early li…
Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress Open
Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depress…
View article: Faculty Opinions recommendation of Hippocampal seed connectome-based modeling predicts the feeling of stress.
Faculty Opinions recommendation of Hippocampal seed connectome-based modeling predicts the feeling of stress. Open
Although the feeling of stress is ubiquitous, the neural mechanisms underlying this affective experience remain unclear. Here, we investigate functional hippocampal connectivity throughout the brain during an acute stressor and use machine…
View article: Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases
Insights into the Therapeutic Potential of Glucocorticoid Receptor Modulators for Neurodegenerative Diseases Open
Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the role of glucocor…
View article: Bornavirus Antigens in Psittaciformes Infected with Psittaciform Bornavirus and their Use in Diagnostic Procedures
Bornavirus Antigens in Psittaciformes Infected with Psittaciform Bornavirus and their Use in Diagnostic Procedures Open
This study describes the occurrence of psittaciform bornavirus antigens and antibodies in tissues of birds persistently infected with psittaciform bornavirus. Analysis of serum of infected birds shows that antibodies against the P40 nucleo…
View article: Stress-induced plasticity and functioning of ventral tegmental dopamine neurons
Stress-induced plasticity and functioning of ventral tegmental dopamine neurons Open
The ventral tegmental area dopamine (VTA-DA) mesolimbic circuit processes emotional, motivational, and social reward associations together with their more demanding cognitive aspects that involve the mesocortical circuitry. Coping with str…