Eran E. Alon
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View article: Surgical Outcomes Following Neoadjuvant‐Targeted Therapy for Advanced Differentiated Thyroid Cancer—Real‐World Data
Surgical Outcomes Following Neoadjuvant‐Targeted Therapy for Advanced Differentiated Thyroid Cancer—Real‐World Data Open
Background Differentiated thyroid carcinoma (DTC) is typically managed surgically with favourable outcomes. However, surgery may have dire consequences when the tumour invades critical structures. Neoadjuvant therapy with tyrosine kinase i…
View article: Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing
Guiding Management of Bethesda V Thyroid Nodules: The Role of Molecular Testing Open
Objective The 2023 Bethesda System update introduced molecular testing as a management option for Bethesda V cytology nodules, aiming to guide surgical decision‐making. This study investigates the correlation between molecular profiling an…
View article: Cost effectiveness analysis of BRAF testing for low-risk papillary thyroid microcarcinomas
Cost effectiveness analysis of BRAF testing for low-risk papillary thyroid microcarcinomas Open
In conclusion, this study demonstrates the economic and clinical advantages of incorporating BRAFV600E genetic testing in the management of lrPTMCs. Our model supports further real-life studies of BRAFV600E testing for lrPTMCs.
View article: Unlocking the potential of large language models in healthcare: navigating the opportunities and challenges
Unlocking the potential of large language models in healthcare: navigating the opportunities and challenges Open
This paper explores the emerging role of large language models (LLMs) in healthcare, offering an analysis of their applications and limitations. Attention mechanisms and transformer architectures enable LLMs to perform tasks like extractin…
View article: Paradigm Change for Intraoperative Surgical Margin Assessment for Oral Squamous Cell Carcinoma
Paradigm Change for Intraoperative Surgical Margin Assessment for Oral Squamous Cell Carcinoma Open
Objective Achieving clear surgical margins is one of the primary surgical goals in treating oral squamous cell carcinoma (OSCC) and thus aiming to improve overall and disease‐specific survival. Therefore, we developed the Goal‐Oriented Ass…
View article: A Five-Decade Text Mining Analysis of Cochlear Implant Research: Where We Started and Where We Are Heading
A Five-Decade Text Mining Analysis of Cochlear Implant Research: Where We Started and Where We Are Heading Open
Background and Objectives: Since its invention in the 1970s, the cochlear implant (CI) has been substantially developed. We aimed to assess the trends in the published literature to characterize CI. Materials and Methods: We queried PubMed…
View article: SAT527 The Management Of Thyroid Cancer: Where We Started And Where We Are Heading? A Five-decades Text Mining Analysis
SAT527 The Management Of Thyroid Cancer: Where We Started And Where We Are Heading? A Five-decades Text Mining Analysis Open
Disclosure: I. Tessler: None. N.A. Gecel: None. G. Avior: None. E. Klang: None. E. Alon: None. T. Kolitz: None. Aim: Thyroid cancer prevalence rate continues to increase, being the most common endocrine cancer. During the years, significan…
View article: Is There a Role for Molecular Testing for Low-Risk Differentiated Thyroid Cancer? A Cost-Effectiveness Analysis
Is There a Role for Molecular Testing for Low-Risk Differentiated Thyroid Cancer? A Cost-Effectiveness Analysis Open
Molecular testing for thyroid nodules has been rapidly developed in recent years, aiming to predict the presence of malignancy and aggressive features. While commonly utilized to predict malignancy, its role in guiding the management appro…
View article: Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory?
Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory? Open
Objectives: Airway management following maxillofacial microvascular reconstruction is a fundamental part of the perioperative management. In oral cavity microvascular reconstruction, the airway is potentially compromised by airway edema, f…
View article: BRAFV600E testing for low-risk papillary thyroid microcarcinomas -- Computational model from a patient-oriented approach
BRAFV600E testing for low-risk papillary thyroid microcarcinomas -- Computational model from a patient-oriented approach Open
Background: Given the good prognosis of low-risk papillary thyroid microcarcinomas (lrPTMCs) accurate risk stratification is valuable to optimize management: active surveillance vs. surgery. BRAFV600E testing was associated with increased …
View article: Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory?
Airway management following head and neck microvascular reconstruction: is tracheostomy mandatory? Open
OBJECTIVES: Airway management following maxillofacial microvascular reconstruction is a fundamental part of the perioperative management. In oral cavity microvascular reconstruction, the airway is potentially compromised by airway edema, f…
View article: Staged Head and Neck Reconstruction: Heresy or a Reasoned Approach in a Select Group of Patients?
Staged Head and Neck Reconstruction: Heresy or a Reasoned Approach in a Select Group of Patients? Open
Study Design: case series. Objective: The restoration of defects in a single procedure with microvascular free flap reconstruction has become a mainstay of head and neck surgery. Yet in patients with complex defects and pre-existing comorb…
View article: RETRACTED: Tumor Microenvironment in Oral Cancer Following Neoadjuvant Pembrolizumab: Preliminary Analysis of the Histopathologic Findings
RETRACTED: Tumor Microenvironment in Oral Cancer Following Neoadjuvant Pembrolizumab: Preliminary Analysis of the Histopathologic Findings Open
Background: The tumor microenvironment (TME) of oral squamous cell carcinoma (OSCC) is associated with immune suppression, one of the pathways being the programmed death receptor 1 (PD-1) and its ligands (PD-L1/PD-L2). Checkpoint inhibitor…
View article: The significance of Computed Tomography in invasive paranasal mucormycosis
The significance of Computed Tomography in invasive paranasal mucormycosis Open
Bony erosion on paranasal CT is an exceptionally insensitive radiologic sign for establishing or rejecting the diagnosis of Mucor induced AIFR. The mainstay of confirming or rejecting the diagnosis of AIFR is by physical examination, endos…
View article: Prognostic value of lymph node ratio in head and neck squamous cell carcinoma
Prognostic value of lymph node ratio in head and neck squamous cell carcinoma Open
Background Lymph node ratio (LNR) is increasingly reported as a potential prognostic tool. The purpose of this review was to analyze the available literature on the prognostic significance of LNR in head and neck squamous cell carcinoma (H…
View article: Prognostic value of lymph node ratio in metastatic papillary thyroid carcinoma
Prognostic value of lymph node ratio in metastatic papillary thyroid carcinoma Open
Objective: Cervical metastases in papillary thyroid carcinoma are associated with increased recurrence. However, their effect on survival remains controversial. This study evaluated literature on the prognostic value of lymph node ratio fo…