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View article: The Global Bioequivalence Harmonisation Initiative (GBHI): Report of the sixth international EUFEPS/PQRI conference
The Global Bioequivalence Harmonisation Initiative (GBHI): Report of the sixth international EUFEPS/PQRI conference Open
At the 6th International Conference of the Global Bioequivalence Harmonisation Initiative (GBHI), co-organised by the European Federation of Pharmaceutical Sciences (EUFEPS) and the Product Quality Research Institute (PQRI), critical bioeq…
View article: Folate Receptor β (FRβ) Expression on Myeloid Cells and the Impact of Reticuloendothelial System on Folate-Functionalized Nanoparticles’ Biodistribution in Cancer
Folate Receptor β (FRβ) Expression on Myeloid Cells and the Impact of Reticuloendothelial System on Folate-Functionalized Nanoparticles’ Biodistribution in Cancer Open
Folate uptake is largely mediated by folate receptor (FR)β, encoded by FOLR2 gene, in myeloid immune cells such as granulocytes, monocytes, and especially in macrophages that constitute the reticuloendothelial system (RES) and infiltrate t…
View article: 58P Novel nanoACPA delivery system presents antitumor effect on ectopic non-small cell lung cancer xenograft model
58P Novel nanoACPA delivery system presents antitumor effect on ectopic non-small cell lung cancer xenograft model Open
Non-small cell lung cancer (NSCLC) constitutes 87% of all lung cancer cases as a late diagnosed tumor with highest mortality rate. We previously reported cannabinoid 1 (CB1) receptor-mediated apoptotic effect of CB1 agonist Arachidonoylcyc…
View article: Design and Characterization of Carboplatin and Paclitaxel Loaded PCL Filaments for 3D Printed Controlled Release Intrauterine Implants
Design and Characterization of Carboplatin and Paclitaxel Loaded PCL Filaments for 3D Printed Controlled Release Intrauterine Implants Open
Uterine cancer is the fourth most common cancer in women. Despite various chemotherapy approaches, the desired effect has not yet been achieved. The main reason is each patient responds differently to standard treatment protocols. The prod…
View article: Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors
Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors Open
Colorectal cancer (CRC) is the third most diagnosed cancer type globally and ranks second in cancer-related deaths. With the current treatment possibilities, a definitive, safe, and effective treatment approach for CRC has not been present…
View article: Synergistic Antitumor Potency of a Self-Assembling Cyclodextrin Nanoplex for the Co-Delivery of 5-Fluorouracil and Interleukin-2 in the Treatment of Colorectal Cancer
Synergistic Antitumor Potency of a Self-Assembling Cyclodextrin Nanoplex for the Co-Delivery of 5-Fluorouracil and Interleukin-2 in the Treatment of Colorectal Cancer Open
Chemotherapy is the most used method after surgery in the treatment of colon cancer. Cancer cells escape the recognition mechanism of immune system cells to survive and develop chemoresistance. Therefore, the use of immunotherapy in combin…
View article: Use of Biodegradable Natural and Synthetic Polymers in Wound Dressing
Use of Biodegradable Natural and Synthetic Polymers in Wound Dressing Open
Yara iyileşmesi; hemostaz, enflamasyon, hücre çoğalması ve skardokusunun yeniden şekillendirilmesi aşamalarından oluşan sonderece karmaşık bir süreçtir. Bu sürecin gecikmesi ya da bozulması,hastaların yaşam kalitesini düşürerek önemli sağl…
View article: A Review on Cancer Immunotherapy and Applications of Nanotechnology to Chemoimmunotherapy of Different Cancers
A Review on Cancer Immunotherapy and Applications of Nanotechnology to Chemoimmunotherapy of Different Cancers Open
Clinically, different approaches are adopted worldwide for the treatment of cancer, which still ranks second among all causes of death. Immunotherapy for cancer treatment has been the focus of attention in recent years, aiming for an event…
View article: Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo
Therapeutic Efficacy and Biodistribution of Paclitaxel-Bound Amphiphilic Cyclodextrin Nanoparticles: Analyses in 3D Tumor Culture and Tumor-Bearing Animals In Vivo Open
The uniqueness of paclitaxel’s antimitotic action mechanism has fueled research toward its application in more effective and safer cancer treatments. However, the low water solubility, recrystallization, and side effects hinder the clinica…
View article: Q-TOF LC/MS-based Untargeted Metabolomics Approach to Evaluate the Effect of Folate-Conjugated Cyclodextrins on Triple-Negative Breast Cancer Cells
Q-TOF LC/MS-based Untargeted Metabolomics Approach to Evaluate the Effect of Folate-Conjugated Cyclodextrins on Triple-Negative Breast Cancer Cells Open
Background: Breast cancer is a heterogenic disease that comprises of various morphologies with intrinsic subtypes and is principally responsible for casualties among female cancer patients. Triple-negative breast cancer (TNBC) is the most …
View article: Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver
Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver Open
Erlotinib (ERL), a tyrosine kinase inhibitor approved for therapeutic use in non-small cell lung cancer is further researched for eventual liver cancer treatment. However, conventional ERL has important bioavailability problems resulting f…
View article: The Effect of <i>Quercus coccifera L.</i> Extract on the Necrosis of Random-pattern Skin Flaps in Rats
The Effect of <i>Quercus coccifera L.</i> Extract on the Necrosis of Random-pattern Skin Flaps in Rats Open
Aim:Ischemia-reperfusion injury is an important cause of flap loss. We investigated effects of Quercus coccifera L. extract known to have anti-oxidant and anti-inflammatory activity on skin flap viability.Methods:Eighteen Wistar rats were …
View article: Cellular Interaction and Tumoral Penetration Properties of Cyclodextrin Nanoparticles on 3D Breast Tumor Model
Cellular Interaction and Tumoral Penetration Properties of Cyclodextrin Nanoparticles on 3D Breast Tumor Model Open
Amphiphilic cyclodextrins are biocompatible oligosaccharides that can be used for drug delivery especially for the delivery of drugs with solubility problems thanks to their unique molecular structures. In this paper, Paclitaxel was used a…
View article: The effect of Arnebia purpurea extract on the survival of random pattern skin flaps in rats
The effect of Arnebia purpurea extract on the survival of random pattern skin flaps in rats Open
Objectives. One of the important causes of flaplosses is ischemia-reperfusion damage. Arnebia species arerich in naphthoquinone derivatives which known to have anti-inflammatory and anti-oxidanteffects. The aim of the present study was to …
View article: Development and Characterization of Paclitaxel-Loaded PLGA Nanoparticles and Cytotoxicity Assessment by MTT Assay on A549 Cell Line
Development and Characterization of Paclitaxel-Loaded PLGA Nanoparticles and Cytotoxicity Assessment by MTT Assay on A549 Cell Line Open
Paclitaxel (PTX) is a cytotoxic agent derived from Taxus brevifolia used for lung cancer. Poly d,l-lactide- co-glycolide (PLGA) is an FDA-approved biodegradable polymer used for preparation of nanoparticles carrying cytotoxic drug agents. …
View article: Development and Characterization of Paclitaxel-loaded PLGA Nanoparticles and Evaluation of Cytotoxicity on MCF-7 Cell Line by MTT Assay
Development and Characterization of Paclitaxel-loaded PLGA Nanoparticles and Evaluation of Cytotoxicity on MCF-7 Cell Line by MTT Assay Open
Paclitaxel (PTX), cytotoxic agent extracted from Taxus brevifolia has significant antineoplastic activity against breast cancer. Poly d,l-lactide-co-glycolide (PLGA) has been widely used for the preparation of nanoparticles carrying cytoto…
View article: Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery
Development of polycationic amphiphilic cyclodextrin nanoparticles for anticancer drug delivery Open
Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclit…
View article: Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment
Cationic PEGylated polycaprolactone nanoparticles carrying post-operation docetaxel for glioma treatment Open
Background: Brain tumors are the most common tumors among adolescents. Although some chemotherapeutics are known to be effective against brain tumors based on cell culture studies, the same effect is not observed in clinical trials. For th…