Erhei Dai
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View article: Distinct features of humoral and cellular immunity against Omicron breakthrough infection among chronic liver disease patients: An experience from a follow-up cohort
Distinct features of humoral and cellular immunity against Omicron breakthrough infection among chronic liver disease patients: An experience from a follow-up cohort Open
Immunity response following vaccination and infection toward the SARS-CoV-2 Omicron variant remains limited in chronic liver disease (CLD) population. This study aims to investigate humoral and cell-mediate immunity to Omicron BA.4/5 among…
View article: Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China
Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China Open
Introduction Hepatitis B virus (HBV) infection poses a major global public health challenge. Recent studies have highlighted the clinical implications of coinfection with the hepatitis E virus (HEV) in HBV-infected individuals, as this dua…
View article: Humoral Immune Response to Breakthrough Infection With SARS‐CoV‐2 Delta and Omicron Variants
Humoral Immune Response to Breakthrough Infection With SARS‐CoV‐2 Delta and Omicron Variants Open
Background Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), continues to impose a significant global health burden. Limited data exist regarding antibody responses to breakthrough…
View article: Mass Cytometry Analysis of High-Dimensional Single-Cell Immune Profiles in ZF2001-Vaccinated Patients Infected with SARS-CoV-2
Mass Cytometry Analysis of High-Dimensional Single-Cell Immune Profiles in ZF2001-Vaccinated Patients Infected with SARS-CoV-2 Open
Our results provided a detailed single-cell profile of the immune response to SARS-CoV-2 infection in vaccinated patients, highlighting significant changes in immune cell kinetics indicative of an active innate and adaptive immune cell res…
View article: Different immunological characteristics of asymptomatic and symptomatic COVID-19 patients without vaccination in the acute and convalescence stages
Different immunological characteristics of asymptomatic and symptomatic COVID-19 patients without vaccination in the acute and convalescence stages Open
The immune status of Coronavirus disease 2019 (COVID-19) patients in different stages of infection remains difficult to determine. In this study, we performed high-throughput single-cell mass cytometry on peripheral blood samples from 10 C…
View article: Characteristics of patients with non-severe infections of different SARS-CoV-2 omicron subvariants in China
Characteristics of patients with non-severe infections of different SARS-CoV-2 omicron subvariants in China Open
Objective The aim of this study was to explore the clinical characteristics of patients infected with different Omicron subvariants presenting non-severe disease, evaluate the safety and efficacy of Azvudine for treatment of COVID-19, in o…
View article: Tenofovir and Hepatitis B Virus Transmission During Pregnancy
Tenofovir and Hepatitis B Virus Transmission During Pregnancy Open
Importance Standard care for preventing mother-to-child transmission (MTCT) of hepatitis B virus (HBV) in highly viremic mothers consists of maternal antiviral prophylaxis beginning at gestational week 28 combined with an HBV vaccine serie…
View article: Humoral Immunity and Clinical Characteristics of Chinese College Students Experiencing a BA.5/BF.7 and XBB.1.5 wave
Humoral Immunity and Clinical Characteristics of Chinese College Students Experiencing a BA.5/BF.7 and XBB.1.5 wave Open
Objectives To investigate the humoral immunity and clinical characteristics of Chinese college students after experiencing a BA.5/BF.7 and/or XBB.1.5 wave. Methods We enrolled 876 college students who received 2–3 vaccination doses of COVI…
View article: Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study
Prognostic impact of age on outcomes of hepatic decompensation in patients with compensated cirrhosis (CHESS2102): an international, multicenter cohort study Open
Baveno VII criteria (B7C) and Baveno VI criteria (B6C) have been widely used to estimate the risk of hepatic decompensation. However, the impact of age on these criteria warrants further investigation. The international, multicenter cohort…
View article: Spatial and Single‐Cell Transcriptomics Reveals the Regional Division of the Spatial Structure of <scp>MASH</scp> Fibrosis
Spatial and Single‐Cell Transcriptomics Reveals the Regional Division of the Spatial Structure of <span>MASH</span> Fibrosis Open
Objective To elucidate the regional distribution of metabolic dysfunction‐associated steatohepatitis (MASH) fibrosis within the liver and to identify potential therapeutic targets for MASH fibrosis. Methods Liver sections from healthy cont…
View article: Pollutants-mediated viral hepatitis in different types: assessment of different algorithms and time series models
Pollutants-mediated viral hepatitis in different types: assessment of different algorithms and time series models Open
The escalating frequency of environmental pollution incidents has raised significant concerns regarding the potential health impacts of pollutant fluctuations. Consequently, a comprehensive study on the role of pollutants in the prevalence…
View article: Finite immune imprinting on neutralizing antibody responses to Omicron subvariants by repeated vaccinations
Finite immune imprinting on neutralizing antibody responses to Omicron subvariants by repeated vaccinations Open
Our findings suggest that repeated vaccination with the Wuhan-hu-1 strain imprinted a neutralizing antibody response toward the Wuhan-hu-1 strain with limited effects on the antibody response to the Omicron subvariants.
View article: Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)
Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review) Open
The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor dru…
View article: Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306)
Carvedilol to prevent hepatic decompensation of cirrhosis in patients with clinically significant portal hypertension stratified by new non-invasive model (CHESS2306) Open
Backgrounds/Aims: Non-invasive models stratifying clinically significant portal hypertension (CSPH) are limited. Herein, we developed a new non-invasive model for predicting CSPH in patients with compensated cirrhosis and investigated whet…
View article: Novel Approach: Maternal Tenofovir Alafenamide Prophylaxis to Prevent Hepatitis B Virus Transmission
Novel Approach: Maternal Tenofovir Alafenamide Prophylaxis to Prevent Hepatitis B Virus Transmission Open
Journal Article Accepted manuscript Novel Approach: Maternal TAF Prophylaxis to Prevent HBV Transmission Get access Calvin Q Pan, MD, Calvin Q Pan, MD Guangzhou Medical Research Institute of Infectious Diseases, Center for Liver Diseases, …
View article: Variant-specific antibody response following repeated SARS-CoV-2 vaccination and infection
Variant-specific antibody response following repeated SARS-CoV-2 vaccination and infection Open
The ongoing emergence of SARS-CoV-2 variants poses challenges to the immunity induced by infections and vaccination. We conduct a 6-month longitudinal evaluation of antibody binding and neutralization of sera from individuals with six diff…
View article: Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Preventing Vertical Transmission in Chronic Hepatitis B Mothers: A Systematic Review and Meta-Analysis
Tenofovir Alafenamide Versus Tenofovir Disoproxil Fumarate for Preventing Vertical Transmission in Chronic Hepatitis B Mothers: A Systematic Review and Meta-Analysis Open
Objective International guidelines recommend maternal tenofovir disoproxil fumarate (TDF) therapy accompanied by infant immunoprophylaxis to prevent hepatitis B virus (HBV) mother-to-child transmission (MTCT) in highly viremic mothers. How…
View article: COVID-19 vaccination willingness among people living with HIV in Shijiazhuang, China: a cross-sectional survey
COVID-19 vaccination willingness among people living with HIV in Shijiazhuang, China: a cross-sectional survey Open
Objectives The COVID-19 pandemic imposed an enormous disease and economic burden worldwide. SARS-CoV-2 vaccination is essential to containing the pandemic. People living with HIV (PLWH) may be more vulnerable to severe COVID-19 outcomes; t…
View article: The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B
The function role of HIGD1A in nonalcoholic steatohepatitis from chronic hepatitis B Open
Both in vivo and in vitro CHB model, an upward trend of HIGD1A was observed in the NASH-related inflammatory response. HIGDIA played a protective role in cells against oxidative stress. Our data suggested that HIGD1A may be a positive regu…
View article: Near full-length genome analysis of two novel HIV second recombinant forms in Hebei, China.
Near full-length genome analysis of two novel HIV second recombinant forms in Hebei, China. Open
Individuals infected with HIV-1 among men who have sex with men (MSM) rose rapidly in recent years in China, and such subtypes as CRF01_AE, CRF07_BC, B, and some novel URFs were prevalent among them. Co-circulation of strains among MSM pop…
View article: Carvedilol to prevent decompensation of liver cirrhosis in patients with clinically significant portal hypertension stratified by novel non-invasive model
Carvedilol to prevent decompensation of liver cirrhosis in patients with clinically significant portal hypertension stratified by novel non-invasive model Open
Objective: To develop a novel non-invasive model for CSPH, and investigate whether carvedilol could reduce the risk of decompensation in patients with high-risk CSPH stratified by the novel model. Methods: International multicenter observa…
View article: SARS-CoV-2 Vaccine Uptake among Patients with Chronic Liver Disease: A Cross-Sectional Analysis in Hebei Province, China
SARS-CoV-2 Vaccine Uptake among Patients with Chronic Liver Disease: A Cross-Sectional Analysis in Hebei Province, China Open
Chronic liver disease (CLD) patients have higher mortality and hospitalization rates after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed to explore SARS-CoV-2 vaccine perceptions, side effect…
View article: Inactivated SARS-CoV-2 booster vaccine enhanced immune responses in patients with chronic liver diseases
Inactivated SARS-CoV-2 booster vaccine enhanced immune responses in patients with chronic liver diseases Open
Chronic liver disease (CLD) entails elevated risk of COVID-19 severity and mortality. The effectiveness of the booster dose of inactivated SARS-CoV-2 vaccine in stimulating antibody response in CLD patients is unclear. Therefore, we conduc…
View article: Abundant diversity of accessory genetic elements and associated antimicrobial resistance genes in pseudomonas aeruginosa isolates from a single Chinese hospital
Abundant diversity of accessory genetic elements and associated antimicrobial resistance genes in pseudomonas aeruginosa isolates from a single Chinese hospital Open
Objectives Pseudomonas aeruginosa has intrinsic antibiotic resistance and the strong ability to acquire additional resistance genes. However, a limited number of investigations provide detailed modular structure dissection and evolutionary…