Explanipedia

A cytoplasmic chemoreceptor and reactive oxygen species mediate bacterial chemotaxis to copper Open

Gwennaëlle Louis, Pauline Cherry, Catherine Michaux, Sophie Rahuel-Clermont, Marc Dieu , et al. · 2023

Structural characterisation of amyloidogenic intrinsically disordered zinc finger protein isoforms DPF3b and DPF3a Open

Julien Mignon, Denis Mottet, Tanguy Leyder, Vladimir N. Uversky, Éric A. Perpète , et al. · 2022

A cytoplasmic chemoreceptor and Reactive Oxygen Species mediate bacterial chemotaxis to copper Open

Gwennaëlle Louis, Pauline Cherry, Catherine Michaux, Sophie Rahuel-Clermont, Marc Dieu , et al. · 2022

Chemotaxis is a widespread strategy used by unicellular and multicellular living organisms to maintain their fitness in stressful environments. We previously showed that bacteria can trigger a negative chemotactic response to a copper (Cu)…

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity Open

Amandine Duchemin, Tina O’Grady, Sarah Hanache, Agnès Méreau, Marc Thiry , et al. · 2021

Revealing Intrinsic Disorder and Aggregation Properties of the DPF3a Zinc Finger Protein Open

Julien Mignon, Denis Mottet, Giulia Verrillo, André Matagne, Éric A. Perpète , et al. · 2021

Double PHD fingers 3 (DPF3) is a human epigenetic factor found in the multiprotein BRG1-associated factor (BAF) chromatin remodeling complex. It has two isoforms: DPF3b and DPF3a, but very little is known about the latter. Despite the lack…

Self-standing, conducting and capacitive biomimetic hybrid nanomembranes for selective molecular ion separation Open

Anna Puiggalí‐Jou, Brenda G. Molina, Maximilien Lopes‐Rodrigues, Catherine Michaux, Éric A. Perpète , et al. · 2021

Robust and flexible three-layered polymer nanomembranes with a porin immobilized at the nanoperforations behave as electrochemical supercapacitors and exhibit selective responses against molecular ions as a function of their charge and con…

Free-standing flexible and biomimetic hybrid membranes for ions and ATP transport Open

Brenda G. Molina, Maximilien Lopes‐Rodrigues, Francesc Estrany, Catherine Michaux, Éric A. Perpète , et al. · 2020

Nanofeatures affect the thermal transitions of polymer thin films: a microcantilever-based investigation Open

Maximilien Lopes‐Rodrigues, Didac Martí, Catherine Michaux, Éric A. Perpète, Jordi Puiggalı́ , et al. · 2020

Microcantilever-based technology has been used to study the influence of nanofeatures (i.e. nanopores, nanoperforations and segregated drug nanodomains) on the glass transition temperature and the cold crystallization temperature of PLA th…

Unravelling the refolding of membrane proteins, one of the most challenging therapeutic targets Open

Catherine Michaux, Éric A. Perpète · 2019

Structural and functional characterization of Solanum tuberosum VDAC36 Open

Maximilien Lopes‐Rodrigues, André Matagne, David Zanuy, Carlos Alemán, Éric A. Perpète , et al. · 2019

As it forms water‐filled channel in the mitochondria outer membrane and diffuses essential metabolites such as NADH and ATP, the voltage‐dependent anion channel (VDAC) protein family plays a central role in all eukaryotic cells. In compari…

Molecular cloning and 3D model of a fatty-acid elongase in a carnivorous freshwater teleost, the European perch (Perca fluviatilis) Open

Emmanuel Tinti, Florian Geay, Maximilien Lopes‐Rodrigues, Patrick Kestemont, Éric A. Perpète , et al. · 2019

3D structure of a Brucella melitensis porin: molecular modelling in lipid membranes Open

Maximilien Lopes‐Rodrigues, David Zanuy, Carlos Alemán, Catherine Michaux, Éric A. Perpète · 2018

Brucella melitensis is a pathogenic bacterium responsible for brucellosis in mammals and humans. Its outer membrane proteins (Omp) control the diffusion of solutes through the membrane, and they consequently have a crucial role in t…

Properties of Omp2a-Based Supported Lipid Bilayers: Comparison with Polymeric Bioinspired Membranes Open

Anna Puiggalí‐Jou, Jan Pawłowski, Luís J. del Valle, Catherine Michaux, Éric A. Perpète , et al. · 2018

Omp2a β-barrel outer membrane protein has been reconstituted into supported lipid bilayers (SLBs) to compare the nanomechanical properties (elastic modulus, adhesion forces, and deformation) and functionality of the resulting bioinspired s…

Thermomechanical Response of a Representative Porin for Biomimetics Open

Maximilien Lopes‐Rodrigues, Anna Puiggalí‐Jou, Didac Martí, Luís J. del Valle, Catherine Michaux , et al. · 2018

The thermomechanical response of Omp2a, a representative porin used for the fabrication of smart biomimetic nanomembranes, has been characterized using microcantilever technology and compared with standard proteins. For this purpose, therm…

Influence of the surrounding environment in re-naturalized β-barrel membrane proteins Open

Maximilien Lopes‐Rodrigues, Jordi Triguero, Juan Torras, Éric A. Perpète, Catherine Michaux , et al. · 2018

Outer-membrane porins are currently being used to prepare bioinspired nanomembranes for selective ion transport by immobilizing them into polymeric matrices. However, the fabrication of these protein-integrated devices has been found to be…

Confinement of a β-barrel protein in nanoperforated free-standing nanomembranes for ion transport Open

Anna Puiggalí‐Jou, Maria M. Pérez‐Madrigal, Luís J. del Valle, Elaine Armelín, María Teresa Casas , et al. · 2016

Bioinspired nanodevices for selective ion transport have been tailored by immobilizing a membrane protein inside nanoperforations of a flexible polymeric nanomembranes.

Polypyrrole-Supported Membrane Proteins for Bio-Inspired Ion Channels Open

Maria M. Pérez‐Madrigal, Luís J. del Valle, Elaine Armelín, Catherine Michaux, G. Roussel , et al. · 2015

Biomedical platforms constructed by immobilizing membrane proteins in matrixes made of synthetic organic polymers is a challenge because the structure and function of these proteins are affected by environmental conditions. In this work, a…

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