Eric A. Sobie
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View article: Combine the wet and dry ingredients: Mixing experimental and computational models for a deeper understanding of stem cell‐derived cardiomyocytes
Combine the wet and dry ingredients: Mixing experimental and computational models for a deeper understanding of stem cell‐derived cardiomyocytes Open
Knowledge in cardiac development, heart disease and drug‐induced toxicity has steadily progressed for centuries, but the most recent decades have seen an explosion in technological advancements that have benefited cardiac research. In part…
View article: Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data".
Corrigendum to "Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data". Open
View article: predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs
predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs Open
We have used drug-induced transcriptomic responses and whole-genome sequences in healthy human induced pluripotent stem cells (iPSC)-derived cardiomyocyte lines to identify cellular functional pathways and genomic variants potentially asso…
View article: Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data
Comprehensive Proteomics Metadata and Integrative Web Portals Facilitate Sharing and Integration of LINCS Multiomics Data Open
The Library of Integrated Network-based Cellular Signatures (LINCS), an NIH Common Fund program, has cataloged and analyzed cellular function and molecular activity profiles in response to >80,000 perturbing agents that are potentially dis…
View article: Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes towards a Purkinje Fiber Fate
Transient Notch Activation Converts Pluripotent Stem Cell-Derived Cardiomyocytes towards a Purkinje Fiber Fate Open
Cardiac Purkinje fibers form the most distal part of the ventricular conduction system. They coordinate contraction and play a key role in ventricular arrhythmias. While many cardiac cell types can be generated from human pluripotent stem …
View article: Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments
Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments Open
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have gained traction as a powerful model in cardiac disease and therapeutics research, since iPSCs are self-renewing and can be derived from healthy and diseased patient…
View article: Multiscale mapping of transcriptomic signatures for cardiotoxic drugs
Multiscale mapping of transcriptomic signatures for cardiotoxic drugs Open
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focus on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced-pluripotent-stem-cell-derived cardi…
View article: Cell-to-cell heterogeneity in ion channel conductance impacts substrate vulnerability to arrhythmia
Cell-to-cell heterogeneity in ion channel conductance impacts substrate vulnerability to arrhythmia Open
We investigate the impact of cell-to-cell heterogeneity in ion channel conductance on substrate vulnerability to arrhythmia by measuring the vulnerable window duration in computational cardiomyocyte cable models. We demonstrate a wide rang…
View article: Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments
Creating cell-specific computational models of stem cell-derived cardiomyocytes using optical experiments Open
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have gained traction as a powerful model in cardiac disease and therapeutics research, since iPSCs are self-renewing and can be derived from healthy and diseased patient…
View article: Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors
Predicting individual-specific cardiotoxicity responses induced by tyrosine kinase inhibitors Open
Introduction: Tyrosine kinase inhibitor drugs (TKIs) are highly effective cancer drugs, yet many TKIs are associated with various forms of cardiotoxicity. The mechanisms underlying these drug-induced adverse events remain poorly understood…
View article: Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients
Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy patients Open
View article: Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models
Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models Open
Both experimental and modeling studies have attempted to determine mechanisms by which a small anatomical region, such as the sinoatrial node (SAN), can robustly drive electrical activity in the human heart. However, despite many advances …
View article: Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation
Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation Open
View article: Quantitative approaches to drug safety: The 2022 <scp>PSP</scp> special issue
Quantitative approaches to drug safety: The 2022 <span>PSP</span> special issue Open
As one of three journals within the ASCPT family of publications, CPT:PSP is committed to publishing top-quality work that applies quantitative methods to important issues in drug discovery and development. As the full name of the journal …
View article: Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models
Coupling and Heterogeneity Modulate Pacemaking Capability in Healthy and Diseased Two-Dimensional Sinoatrial Node Tissue Models Open
Both experimental and modeling studies have attempted to determine mechanisms by which a small anatomical region, such as the sinoatrial node (SAN), can robustly drive electrical conduction in the human heart. However, despite important ad…
View article: PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes Open
View article: Two heads are better than one: current landscape of integrating QSP and machine learning
Two heads are better than one: current landscape of integrating QSP and machine learning Open
View article: Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity
Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity Open
Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers for the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. Its key aim is to generate proteomi…
View article: Additional file 1 of Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation
Additional file 1 of Time-regulated transcripts with the potential to modulate human pluripotent stem cell-derived cardiomyocyte differentiation Open
Additional file 1: Supplementary Table S1.
View article: A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals
A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals Open
View article: Multiscale mapping of transcriptomic signatures for cardiotoxic drugs
Multiscale mapping of transcriptomic signatures for cardiotoxic drugs Open
Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focused on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced pluripotent stem cell-derived car…
View article: Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion
Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion Open
During morphogenesis, molecular mechanisms that orchestrate biomechanical dynamics across cells remain unclear. Here, we show a role of guidance receptor Plexin-B2 in organizing actomyosin network and adhesion complexes during multicellula…
View article: Prediction of arrhythmia susceptibility through mathematical modeling and machine learning
Prediction of arrhythmia susceptibility through mathematical modeling and machine learning Open
Significance Despite our understanding of the many factors that promote ventricular arrhythmias, it remains difficult to predict which specific individuals within a population will be especially susceptible to these events. We present a co…
View article: PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes Open
SUMMARY Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) provide an unprecedented opportunity to study human heart development and disease. A major caveat however is that they remain functionally and structurally immature in culture,…
View article: CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision
CPT: Pharmacometrics & Systems Pharmacology – Inception, Maturation, and Future Vision Open
CPT: Pharmacometrics & Systems Pharmacology (PSP) is a cross-disciplinary journal which publishes research articles, reviews and tutorials that bridge various disciplines including pharmacometrics, systems pharmacology modeling, physiologi…
View article: Protein structure–based gene expression signatures
Protein structure–based gene expression signatures Open
Significance Gene expression signatures (GES) are used to define phenotypes, such as cell and tissue state, or the effects of perturbagens. GES have suffered from vague assessment criteria and limited reproducibility. Here, we show that co…
View article: Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development
Inflammation as a Risk Factor in Cardiotoxicity: An Important Consideration for Screening During Drug Development Open
Numerous commonly prescribed drugs, including antiarrhythmics, antihistamines, and antibiotics, carry a proarrhythmic risk and may induce dangerous arrhythmias, including the potentially fatal Torsades de Pointes. For this reason, cardioto…
View article: In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte”
In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte” Open
The rapid dissemination of SARS-CoV-2 has made COVID-19 a tremendous social, economic, and health burden. Despite the efforts to understand the virus and treat the disease, many questions remain unanswered about COVID-19 mechanisms of infe…
View article: Modeling the Crosstalk between Ryanodine and IP3 Receptors in Cardiac Myocytes
Modeling the Crosstalk between Ryanodine and IP3 Receptors in Cardiac Myocytes Open
View article: Machine Learning Techniques to Classify the Severity of Novel SCN5A Variants
Machine Learning Techniques to Classify the Severity of Novel SCN5A Variants Open