Éric Bergeron
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View article: Crimean-Congo hemorrhagic fever virus localization and shedding in the reproductive tract of lethal and survivor mouse models
Crimean-Congo hemorrhagic fever virus localization and shedding in the reproductive tract of lethal and survivor mouse models Open
Hemorrhagic fever viruses have been shown to localize to immune-privileged sites, including the reproductive tract, raising important questions about long-term persistence and the potential for sexual transmission. Anecdotal evidence of se…
View article: Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies
Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies Open
CDC Emerging Infectious Disease Research Core Funds, funding for reagent, CDC personal, travel. Defence Threat Reduction Agency (HDTRA12210007): E.K. salary. Oak Ridge Institute for Science and Education (ORISE): E.K. salary and travel. Na…
View article: Annual (2024) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
Annual (2024) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota) Open
In April 2024, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was expanded by 1 new order, 1 new family, 6 new subfamilies, 34 new genera and …
View article: Inflammation associated with monocyte/macrophage activation and recruitment corresponds with lethal outcome in a mouse model of Crimean-Congo haemorrhagic fever
Inflammation associated with monocyte/macrophage activation and recruitment corresponds with lethal outcome in a mouse model of Crimean-Congo haemorrhagic fever Open
Crimean-Congo haemorrhagic fever virus (CCHFV) causes human disease ranging from subclinical to a fatal haemorrhagic syndrome. Determinants of CCHF pathogenesis are largely unknown and animal models that recapitulate human disease are limi…
View article: A public, cross‐reactive glycoprotein epitope confounds Ebola virus serology
A public, cross‐reactive glycoprotein epitope confounds Ebola virus serology Open
Ebola disease (EBOD) in humans is a severe disease caused by at least four related viruses in the genus Orthoebolavirus , most often by the eponymous Ebola virus. Due to human‐to‐human transmission and incomplete success in treating cases …
View article: Streamlined detection of Nipah virus antibodies using a split NanoLuc biosensor
Streamlined detection of Nipah virus antibodies using a split NanoLuc biosensor Open
Nipah virus (NiV) is an emerging zoonotic RNA virus that can cause fatal respiratory and neurological diseases in animals and humans. Accurate NiV diagnostics and surveillance tools are crucial for the identification of acute and resolved …
View article: Replicon particle vaccination induces non-neutralizing anti-nucleoprotein antibody-mediated control of Crimean-Congo hemorrhagic fever virus
Replicon particle vaccination induces non-neutralizing anti-nucleoprotein antibody-mediated control of Crimean-Congo hemorrhagic fever virus Open
Crimean-Congo hemorrhagic fever virus (CCHFV) can cause severe human disease and is considered a WHO priority pathogen due to the lack of efficacious vaccines and antivirals. A CCHF virus replicon particle (VRP) has previously shown protec…
View article: ICTV Virus Taxonomy Profile: Nairoviridae 2024
ICTV Virus Taxonomy Profile: Nairoviridae 2024 Open
Nairoviridae is a family for negative-sense RNA viruses with genomes of about 17.2–21.1 kb. These viruses are maintained in and/or transmitted by arthropods among birds, reptiles and mammals. Norwaviruses and orthonairoviruses can cause fe…
View article: Characterization of Humoral Responses to Nipah Virus Infection in the Syrian Hamster Model of Disease
Characterization of Humoral Responses to Nipah Virus Infection in the Syrian Hamster Model of Disease Open
Nipah virus (NiV) is a highly pathogenic paramyxovirus. The Syrian hamster model recapitulates key features of human NiV disease and is a critical tool for evaluating antivirals and vaccines. Here we describe longitudinal humoral immune re…
View article: Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination
Recombinant Sudan virus and evaluation of humoral cross-reactivity between Ebola and Sudan virus glycoproteins after infection or rVSV-ΔG-ZEBOV-GP vaccination Open
Ebola disease outbreaks are major public health events because of human-to-human transmission and high mortality. These outbreaks are most often caused by Ebola virus, but at least three related viruses can also cause the disease. In 2022,…
View article: Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota) Open
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new gener…
View article: Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions
Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions Open
Crimean-Congo hemorrhagic fever virus (CCHFV; family Nairoviridae ) is a tick-borne pathogen that frequently causes lethal disease in humans. CCHFV has a wide geographic distribution, and cases have been reported in Africa, Asia, the Middl…
View article: Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination
Single-dose mucosal replicon-particle vaccine protects against lethal Nipah virus infection up to 3 days after vaccination Open
Nipah virus (NiV) causes a highly lethal disease in humans who present with acute respiratory or neurological signs. No vaccines against NiV have been approved to date. Here, we report on the clinical impact of a novel NiV-derived nonsprea…
View article: Development of a neutralization assay using a vesicular stomatitis virus expressing Nipah virus glycoprotein and a fluorescent protein
Development of a neutralization assay using a vesicular stomatitis virus expressing Nipah virus glycoprotein and a fluorescent protein Open
Nipah virus (NiV) is a highly pathogenic paramyxovirus with a high case fatality rate. Due to its high pathogenicity, pandemic potential, and lack of therapeutics or approved vaccines, its study requires biosafety level 4 (BSL4) containmen…
View article: Corrigendum: Editorial: Emerging SARS-CoV-2 variants: genomic variations, transmission, pathogenesis, clinical impact and interventions
Corrigendum: Editorial: Emerging SARS-CoV-2 variants: genomic variations, transmission, pathogenesis, clinical impact and interventions Open
[This corrects the article DOI: 10.3389/fmed.2023.1178696.].
View article: Editorial: Emerging SARS-CoV-2 variants: genomic variations, transmission, pathogenesis, clinical impact, and interventions, volume II
Editorial: Emerging SARS-CoV-2 variants: genomic variations, transmission, pathogenesis, clinical impact, and interventions, volume II Open
EDITORIAL article Front. Med., 28 June 2023Sec. Infectious Diseases: Pathogenesis and Therapy Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1215309
View article: Editorial: Emerging SARS-CoV-2 variants: Genomic variations, transmission, pathogenesis, clinical impact and interventions
Editorial: Emerging SARS-CoV-2 variants: Genomic variations, transmission, pathogenesis, clinical impact and interventions Open
EDITORIAL article Front. Med., 29 March 2023Sec. Infectious Diseases: Pathogenesis and Therapy Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1178696
View article: Editorial: Ubiquitin and ubiquitin-like modifications in viral infection and innate immunity
Editorial: Ubiquitin and ubiquitin-like modifications in viral infection and innate immunity Open
EDITORIAL article Front. Immunol., 02 February 2023Sec. Viral Immunology Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1148296
View article: 1470. Human monoclonal antibodies for the treatment and prevention of Crimean Congo Hemorrhagic Fever
1470. Human monoclonal antibodies for the treatment and prevention of Crimean Congo Hemorrhagic Fever Open
Background Crimean-Congo hemorrhagic fever (CCHF) is the most widely spread viral hemorrhagic disease, found in Europe, Asia, and Africa. The disease symptoms start and progress rapidly and can lead to bruising and bleeding, with high fata…
View article: Structural Characterization of Protective Non-Neutralizing Antibodies targeting Crimean-Congo Hemorrhagic Fever Virus
Structural Characterization of Protective Non-Neutralizing Antibodies targeting Crimean-Congo Hemorrhagic Fever Virus Open
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) causes a life-threatening disease with up to a 40% mortality rate. With no approved medical countermeasures, CCHFV is considered a public health priority agent. The non-neutralizing mouse monoc…
View article: Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report
Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report Open
The COVID‐19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10–13, 2022, researchers across academia, industry, government, and nonprofit organizations met at the Keystone symposium “Les…
View article: Performance of SARS-CoV-2 Antigens in a Multiplex Bead Assay for Integrated Serological Surveillance of Neglected Tropical and Other Diseases
Performance of SARS-CoV-2 Antigens in a Multiplex Bead Assay for Integrated Serological Surveillance of Neglected Tropical and Other Diseases Open
Serosurveillance can provide estimates of population-level exposure to infectious pathogens and has been used extensively during the COVID-19 pandemic. Simultaneous, serological testing for multiple pathogens can be done using bead-based i…