Eric Block
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View article: Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis and Chemistry
Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis and Chemistry Open
We report the first syntheses—from commercially available 3-chloro-2-fluoroprop-1-ene (9)—of key garlic-derived compounds containing sp2-fluorine. We also report synthesis of fluoro-5,6-dihydrothiopyrans by trapping 2-fluorothioacrolein (1…
View article: RETRACTED: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081
RETRACTED: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081 Open
The Journal retracts the article “Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies” [...]
View article: Porous Coordination Cages: Acceptable levels of structure completion
Porous Coordination Cages: Acceptable levels of structure completion Open
Crystallographers are charged with obtaining the best possible model based on available data. What happens when there are inherent intrinsic properties of the compounds under study that prevent the usual levels of data quality? Several str…
View article: Re-examination of the Claimed Isolation of Stable Noncyclic 1,2-Disulfoxides
Re-examination of the Claimed Isolation of Stable Noncyclic 1,2-Disulfoxides Open
Re-examination of the claimed isolation and X-ray characterization of di-p-tolyl and dimesityl 1,2-disulfoxides from thermolysis of the corresponding aryl sulfinimines and thiosulfinates showed that the isolated disulfide dioxides are inst…
View article: Correction: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081
Correction: Block et al. Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies. Molecules 2017, 22, 2081 Open
In the original publication [...]
View article: Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic
Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic Open
Understanding how genes and experience work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the main olfactory epithelium, a chemosensory structure with over a…
View article: Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic
Semiochemical responsive olfactory sensory neurons are sexually dimorphic and plastic Open
Understanding how genes and experiences work in concert to generate phenotypic variability will provide a better understanding of individuality. Here, we considered this in the context of the main olfactory epithelium, a chemosensory struc…
View article: Ajothiolanes: 3,4-Dimethylthiolane Natural Products from Garlic (<i>Allium sativum</i>)
Ajothiolanes: 3,4-Dimethylthiolane Natural Products from Garlic (<i>Allium sativum</i>) Open
Stereoisomers of 5-(2-allylsulfinyl)-3,4-dimethylthiolane-2-ol, a family of 3,4-dimethylthiolanes of formula C9H16O2S2 we name ajothiolanes, were isolated from garlic ( Allium sativum) macerates and characterized by a variety of analytical…
View article: Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by ( <i>R</i> )-muscone and diverse other musk-smelling compounds
Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by ( <i>R</i> )-muscone and diverse other musk-smelling compounds Open
Significance While natural musk has been used for 2,000 years in perfumery, and in traditional medicine for its cardioprotective effects, its mode of activating odorant receptors (ORs) is unknown. ORs, G protein-coupled receptors (GPCRs), …
View article: A Multispecific Investigation of the Metal Effect in Mammalian Odorant Receptors for Sulfur-Containing Compounds
A Multispecific Investigation of the Metal Effect in Mammalian Odorant Receptors for Sulfur-Containing Compounds Open
Metal-coordinating compounds are generally known to have strong smells, a phenomenon that can be attributed to the fact that odorant receptors for intense-smelling compounds, such as those containing sulfur, may be metalloproteins. We prev…
View article: RETRACTED: Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies
RETRACTED: Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies Open
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commerciall…
View article: Photochemically Generated Thiyl Free Radicals Observed by X-ray Absorption Spectroscopy
Photochemically Generated Thiyl Free Radicals Observed by X-ray Absorption Spectroscopy Open
Sulfur-based thiyl radicals are known to be involved in a wide range of chemical and biological processes, but they are often highly reactive, which makes them difficult to observe directly. We report herein X-ray absorption spectra and an…
View article: The role of metals in mammalian olfaction of low molecular weight organosulfur compounds
The role of metals in mammalian olfaction of low molecular weight organosulfur compounds Open
We highlight the role that copper and other metals play in mammalian olfaction of low molecular weight organosulfur compounds from both natural and non-natural sources.
View article: Trifluoroselenomethionine: A New Unnatural Amino Acid
Trifluoroselenomethionine: A New Unnatural Amino Acid Open
Trifluoroselenomethionine (TFSeM), a new unnatural amino acid, was synthesized in seven steps from N ‐( tert ‐butoxycarbonyl)‐ l ‐aspartic acid tert ‐butyl ester. TFSeM shows enhanced methioninase‐induced cytotoxicity, relative to selenome…
View article: Reply to Turin et al.: Vibrational theory of olfaction is implausible
Reply to Turin et al.: Vibrational theory of olfaction is implausible Open
We thank Turin et al. (1) for their comments regarding our paper (2). In response to the first point of Turin et al. (1), concerning the musk receptor screen, our reported results (2) were directed at testing the main hypothesis of the vib…
View article: Implausibility of the vibrational theory of olfaction
Implausibility of the vibrational theory of olfaction Open
Significance The vibrational theory of olfaction posits detection of odorants through their vibrational frequencies rather than solely through “hand-in-glove” substrate/enzyme-like odorant–odorant receptor (OR) interactions. To test the th…