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View article: IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies
IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies Open
Iron regulatory protein 1 (IRP1) is a post-transcriptional regulator of cellular iron metabolism. In mice, loss of IRP1 causes polycythemia through translational de-repression of hypoxia-inducible factor 2α (HIF2α) mRNA, which increases re…
View article: Mono-allelic p.R37H Dehydrodolichyl Diphosphate Synthase variants lead to protein glycosylation defects, aberrant lipid profiles and interneuron scarcity in a novel mouse model of progressive epileptic encephalopathy
Mono-allelic p.R37H Dehydrodolichyl Diphosphate Synthase variants lead to protein glycosylation defects, aberrant lipid profiles and interneuron scarcity in a novel mouse model of progressive epileptic encephalopathy Open
Developmental delay and seizures with or without movement abnormalities (OMIM 617836) caused by heterozygous pathogenic variants in the DHDDS gene (DHDDS-CDG) is a rare genetic disease that belongs to the progressive encephalopathy spectru…
View article: O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis
O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis Open
The E2F transcription factors constitute a core transcriptional network that governs cell division and oncogenesis in multi-cellular organisms, although their molecular mechanisms remain incompletely understood. Here, we show that elevated…
View article: Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A
Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A Open
Sphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation. Here we show that these compounds directly bind not only the…
View article: Enriching for Extracellular Vesicles from Human Bone
Enriching for Extracellular Vesicles from Human Bone Open
Extracellular vesicles (EVs) are nano-sized membrane-bound structures thought to be secreted by all cells and increasingly recognized as key mediators of intercellular communication. Established EV isolation protocols for bodily fluids-pri…
View article: Endothelial extracellular vesicle miR-423-5p regulates microvascular homeostasis and renal function after ischemia-reperfusion injury
Endothelial extracellular vesicle miR-423-5p regulates microvascular homeostasis and renal function after ischemia-reperfusion injury Open
Microvascular rarefaction substantially contributes to renal dysfunction following ischemia-reperfusion injury (IRI). We characterized the microRNA signature of extracellular vesicles (EVs) released during endothelial apoptosis to identify…
View article: Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1
Immunosuppressive myeloid cells induce mesenchymal-like breast cancer stem cells by a mechanism involving membrane-bound TGF-β1 Open
Summary Suppressive myeloid cells play a central role in cancer escape from anti-tumor immunity. Beyond their immunosuppressive function, these cells are capable of exerting multiple other pro-tumoral activities, including the promotion of…
View article: Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis Open
In animals, mitosis involves the breakdown of the nucleus. The reassembly of a nucleus after mitosis requires the reformation of the nuclear envelope around a single mass of chromosomes. This process requires Ankle2 (also known as LEM4 in …
View article: Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis Open
In animals, mitosis involves the breakdown of the nucleus. The reassembly of a nucleus after mitosis requires the reformation of the nuclear envelope around a single mass of chromosomes. This process requires Ankle2 (also known as LEM4 in …
View article: Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis Open
In animals, mitosis involves the breakdown of the nucleus. The reassembly of a nucleus after mitosis requires the reformation of the nuclear envelope around a single mass of chromosomes. This process requires Ankle2 (also known as LEM4 in …
View article: Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis Open
In animals, mitosis involves the breakdown of the nucleus. The reassembly of a nucleus after mitosis requires the reformation of the nuclear envelope around a single mass of chromosomes. This process requires Ankle2 which interacts with PP…
View article: Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines
Comparative small molecule screening of primary human acute leukemias, engineered human leukemia and leukemia cell lines Open
Targeted therapeutics for high-risk cancers remain an unmet medical need. Here we report the results of a large-scale screen of over 11,000 molecules for their ability to inhibit the survival and growth in vitro of human leukemic cells fro…
View article: Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis
Mechanisms of PP2A-Ankle2 dependent nuclear reassembly after mitosis Open
In animals, mitosis involves the breakdown of the nucleus. The reassembly of a nucleus after mitosis requires the reformation of the nuclear envelope around a single mass of chromosomes. This process requires Ankle2 (also known as LEM4 in …
View article: Proteomic Blueprint of Atlantic Cod (Gadus morhua) Otoliths Revealing Environmental Stress Insights through Label-Free Quantitative Shotgun Proteomics
Proteomic Blueprint of Atlantic Cod (Gadus morhua) Otoliths Revealing Environmental Stress Insights through Label-Free Quantitative Shotgun Proteomics Open
Otoliths of the fish’s inner ear serve as a natural chronological recorder because of their continuous formation marked by daily, monthly, and annual increments. Despite their importance, the comprehensive protein content of otoliths remai…
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the role of TEs on T-cell developme…
View article: Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression
Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression Open
Rhes (Ras homolog enriched in the striatum), a multifunctional protein that regulates striatal functions associated with motor behaviors and neurological diseases, can shuttle from cell to cell via the formation of tunneling-like nanotubes…
View article: Reviewer #2 (Public Review): Transposable elements regulate thymus development and function
Reviewer #2 (Public Review): Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Author Response: Transposable elements regulate thymus development and function
Author Response: Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Reviewer #1 (Public Review): Transposable elements regulate thymus development and function
Reviewer #1 (Public Review): Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: Transposable elements regulate thymus development and function
Transposable elements regulate thymus development and function Open
Transposable elements (TE) are repetitive sequences representing ∼45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTEC). In this study, we investigated the role of TEs on T-cell development…
View article: <i>SF3B1</i> mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia
<i>SF3B1</i> mutations provide genetic vulnerability to copper ionophores in human acute myeloid leukemia Open
In a phenotypical screen of 56 acute myeloid leukemia (AML) patient samples and using a library of 10,000 compounds, we identified a hit with increased sensitivity toward SF3B1 -mutated and adverse risk AMLs. Through structure-activity rel…
View article: O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis
O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis Open
Gene transcription is a highly regulated process, and deregulation of transcription factors activity underlies numerous pathologies including cancer. Albeit near four decades of studies have established that the E2F pathway is a core trans…