Eric C. Dunham
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View article: Wood–Ljungdahl pathway encoding anaerobes facilitate low-cost primary production in hypersaline sediments at Great Salt Lake, Utah
Wood–Ljungdahl pathway encoding anaerobes facilitate low-cost primary production in hypersaline sediments at Great Salt Lake, Utah Open
Little is known of primary production in dark hypersaline ecosystems despite the prevalence of such environments on Earth today and throughout its geologic history. Here, we generated and analyzed metagenome-assembled genomes (MAGs) organi…
View article: Lithogenic hydrogen supports microbial primary production in subglacial and proglacial environments
Lithogenic hydrogen supports microbial primary production in subglacial and proglacial environments Open
Significance In the absence of light, biomass production is driven by chemical energy through microbial chemosynthesis. H 2 , a potent reductant capable of supporting chemosynthesis, is readily generated by reactions between iron and silic…
View article: An Ecological Perspective on Dolomite Formation in Great Salt Lake, Utah
An Ecological Perspective on Dolomite Formation in Great Salt Lake, Utah Open
Protodolomite was detected in sediments from Great Salt Lake (GSL), Utah, United States, that have no history of elevated temperature or pressure, conditions that are thought to promote dolomitization of sedimentary carbonates. Protodolomi…
View article: Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes
Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes Open
Twelve evolutionarily unrelated oxidoreductases form enzyme complexes that catalyze the simultaneous coupling of exergonic and endergonic oxidation-reduction reactions to circumvent thermodynamic barriers and minimize free energy loss in a…
View article: A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle Open
View article: Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses
Lifecycle modelling systems support inosine monophosphate dehydrogenase (IMPDH) as a pro-viral factor and antiviral target for New World arenaviruses Open
View article: Additional file 5: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
Additional file 5: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle Open
Results of secondary screen, excel file format. (XLSX 50 kb)
View article: Additional file 6: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
Additional file 6: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle Open
Results of secondary assay, excel file format. (XLSX 18 kb)
View article: Additional file 2: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
Additional file 2: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle Open
Uncorrected and seed-corrected logP values from RSA analysis, excel file format. (XLSX 1121 kb)
View article: Additional file 3: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle
Additional file 3: of A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle Open
Genes selected for follow-up, excel file format. (XLSX 14 kb)
View article: Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging
Ebola virus VP24 interacts with NP to facilitate nucleocapsid assembly and genome packaging Open
View article: Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses
Assessing the contribution of interferon antagonism to the virulence of West African Ebola viruses Open
The current Ebola virus (EBOV) outbreak in West Africa is unprecedented in terms of both its size and duration, and there has been speculation and concern regarding the potential for EBOV to increase in virulence as a result of its prolong…